日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular basis for different substrate-binding sites and chaperone functions of the BRICHOS domain

BRICHOS 结构域不同底物结合位点和分子伴侣功能的分子基础

Gefei Chen, Yu Wang, Zihan Zheng, Wangshu Jiang, Axel Leppert, Xueying Zhong, Anna Belorusova, Gregg Siegal, Caroline Jegerschöld, Philip J B Koeck, Axel Abelein, Hans Hebert, Stefan D Knight, Jan Johansson

The membrane-cytoplasmic linker defines activity of FtsH proteases in Pseudomonas aeruginosa clone C

膜-胞质接头决定了铜绿假单胞菌克隆C中FtsH蛋白酶的活性

Gina D Mawla, Shady M Kamal, Lian-Ying Cao, Pasi Purhonen, Hans Hebert, Robert T Sauer, Tania A Baker, Ute Römling

Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation

BRICHOS 结构域中的短疏水环基序决定了分子伴侣对抗无定形蛋白质聚集的活性,但不对抗淀粉样蛋白的形成

Gefei Chen #, Axel Leppert #, Helen Poska, Harriet E Nilsson, Carlos Piedrafita Alvira, Xueying Zhong, Philip Koeck, Caroline Jegerschöld, Axel Abelein, Hans Hebert, Jan Johansson

Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue

BRICHOS 结构域预防神经毒性和纤维形成的能力依赖于高度保守的 Asp 残基

Gefei Chen, Yuniesky Andrade-Talavera, Xueying Zhong, Sameer Hassan, Henrik Biverstål, Helen Poska, Axel Abelein, Axel Leppert, Nina Kronqvist, Anna Rising, Hans Hebert, Philip J B Koeck, André Fisahn, Jan Johansson

Cryo-EM structure of native human uromodulin, a zona pellucida module polymer

天然人类尿调节蛋白(透明带模块聚合物)的低温电子显微镜结构

Alena Stsiapanava, Chenrui Xu, Martina Brunati, Sara Zamora-Caballero, Céline Schaeffer, Marcel Bokhove, Ling Han, Hans Hebert, Marta Carroni, Shigeki Yasumasu, Luca Rampoldi, Bin Wu, Luca Jovine

The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain

亨廷顿蛋白 N 端的聚谷氨酰胺扩增调节 C 端 HEAT 结构域的动态结构和磷酸化

Taeyang Jung, Baehyun Shin, Giorgio Tamo, Hyeongju Kim, Ravi Vijayvargia, Alexander Leitner, Maria J Marcaida, Juan Astorga-Wells, Roy Jung, Ruedi Aebersold, Matteo Dal Peraro, Hans Hebert, Ihn Sik Seong, Ji-Joon Song

Crocus-derived compounds alter the aggregation pathway of Alzheimer's Disease: associated beta amyloid protein

番红花衍生化合物改变阿尔茨海默病的聚集途径:相关β淀粉样蛋白

Nikolaos Stavros Koulakiotis, Pasi Purhonen, Evangelos Gikas, Hans Hebert, Anthony Tsarbopoulos

Recombinant Bri3 BRICHOS domain is a molecular chaperone with effect against amyloid formation and non-fibrillar protein aggregation

重组 Bri3 BRICHOS 结构域是一种分子伴侣,具有抗淀粉样蛋白形成和非纤维蛋白聚集的作用

Helen Poska, Axel Leppert, Helene Tigro, Xueying Zhong, Margit Kaldmäe, Harriet E Nilsson, Hans Hebert, Gefei Chen, Jan Johansson

Efficient protein production inspired by how spiders make silk

受蜘蛛吐丝方式的启发,开发出高效的蛋白质生产方法。

Kronqvist, Nina; Sarr, Médoune; Lindqvist, Anton; Nordling, Kerstin; Otikovs, Martins; Venturi, Luca; Pioselli, Barbara; Purhonen, Pasi; Landreh, Michael; Biverstål, Henrik; Toleikis, Zigmantas; Sjöberg, Lisa; Robinson, Carol V; Pelizzi, Nicola; Jörnvall, Hans; Hebert, Hans; Jaudzems, Kristaps; Curstedt, Tore; Rising, Anna; Johansson, Jan

The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin

正常气管由 MUC5B 粘蛋白束从被 MUC5AC 粘蛋白包裹的粘膜下腺中清除

Anna Ermund, Lauren N Meiss, Ana M Rodriguez-Pineiro, Andrea Bähr, Harriet E Nilsson, Sergio Trillo-Muyo, Caroline Ridley, David J Thornton, Jeffrey J Wine, Hans Hebert, Nikolai Klymiuk, Gunnar C Hansson