日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Recommended Tool Compounds: Isoform- and Class-Specific Histone Deacetylase Inhibitors

推荐的工具化合物:同工型和类别特异性组蛋白去乙酰化酶抑制剂

Schäker-Hübner, Linda; Hansen, Finn K

Generation and validation of a novel multitarget small molecule in glioblastoma.

胶质母细胞瘤新型多靶点小分子的生成与验证

Artetxe-Zurutuza Aizpea, Iturrioz-Rodriguez Nerea, Elizazu Joseba, Toledano-Pinedo Mireia, Porro-Pérez Alicia, De Goñi Irati, Elua-Pinin Alejandro, Schäker-Hübner Linda, Azkargorta Mikel, Elortza Felix, Iriepa Isabel, Lòpez-Muñoz Francisco, Moncho-Amor Veronica, Hansen Finn K, Sampron Nicolás, Marco-Contelles Jose Luis, Matheu Ander

Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties.

探索组蛋白去乙酰化酶 (HDAC) 抑制剂中的替代锌结合基团,发现 DS-103 是一种具有化学增敏特性的强效乙基肼基 HDAC 抑制剂

Stopper Daniel, Biermann Lukas, Watson Paris R, Li Jingyu, König Beate, Gaynes Matthew N, Pessanha de Carvalho Lais, Klose Jana, Hanl Maria, Hamacher Alexandra, Schäker-Hübner Linda, Ramsbeck Daniel, Held Jana, Christianson David W, Kassack Matthias U, Hansen Finn K

Development and Characterization of the First Selective Class IIb Histone Deacetylase Degraders.

首个选择性 IIb 类组蛋白去乙酰化酶降解剂的开发和表征

Zhai Shiyang, Honin Irina, Schäker-Hübner Linda, Hanl Maria, Jacobi Lukas, Dressler Finn, Pieńkowska Dominika Ewa, König Philipp, Gerhartz Jan, Voget Rabea, Bendas Gerd, Gütschow Michael, Meissner Felix, Burckhardt Bjoern B, Nowak Radosław P, Steinebach Christian, Hansen Finn K

Targeted Histone Deacetylase Degradation via Chemical Induced Proximity by Direct Recruitment of the CUL4 Complex Adaptor Protein DDB1

通过化学诱导的邻近效应,直接募集 CUL4 复合物衔接蛋白 DDB1 靶向降解组蛋白去乙酰化酶

Zhai, Shiyang; Willemsen, Nicola; Sun, Tao; Malenica, Mateo; Deng, Shixin; Geyer, Matthias; Hansen, Finn K

Targeted Degradation of Histone Deacetylases via Bypassing E3 Ligase Targeting Chimeras (BYETACs)

通过绕过 E3 连接酶靶向嵌合体 (BYETACs) 靶向降解组蛋白去乙酰化酶

Sun, Tao; Zhai, Shiyang; König, Beate; Honin, Irina; Kponomaizoun, Cindy-Esther; Hansen, Finn K

Development of Ethyl-Hydrazide-Based Selective Histone Deacetylase 6 (HDAC6) PROTACs

基于乙肼的选择性组蛋白去乙酰化酶6 (HDAC6) PROTACs 的开发

Stopper, Daniel; Honin, Irina; Feller, Felix; Hansen, Finn K

The Histone Deacetylase Inhibitor Entinostat Mediates HER2 Downregulation in Gastric Cancer, Providing the Basis for Its Particular Efficacy in HER2-Amplified Tumors and in Combination Therapies

组蛋白去乙酰化酶抑制剂恩替诺特介导胃癌中HER2的下调,这为其在HER2扩增肿瘤和联合疗法中的特殊疗效提供了基础。

Zenz, Tamara; Jenke, Robert; Thieme, René; Kahl, Tim; Borchardt, Hannes; Gockel, Ines; Hansen, Finn K; Aigner, Achim; Büch, Thomas R H

Target Engagement Studies and Kinetic Live-Cell Degradation Assays Enable the Systematic Characterization of Histone Deacetylase 6 Degraders

靶标结合研究和动力学活细胞降解分析能够系统地表征组蛋白去乙酰化酶 6 降解剂

Hanl, Maria; Feller, Felix; Honin, Irina; Tan, Kathrin; Miranda, Martina; Schäker-Hübner, Linda; Bückreiß, Nico; Schiedel, Matthias; Gütschow, Michael; Bendas, Gerd; Hansen, Finn K

Contilisant-Belinostat Hybrids: Polyfunctionalized Indole Derivatives as Multineurotarget Drugs for the Potential Treatment of Alzheimer's Disease

康替利生-贝利司他杂合物:多功能吲哚衍生物作为多靶点神经药物,有望用于治疗阿尔茨海默病

Schäker-Hübner, Linda; Toledano-Pinedo, Mireia; Eimermacher, Sophia; Krasniqi, Vesa; Porro-Pérez, Alicia; Tan, Kathrin; Horn, Gabriele; Stegen, Philipp; Elsinghorst, Paul W; Wille, Timo; Pietsch, Markus; Gütschow, Michael; Marco-Contelles, José; Hansen, Finn K