日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A robust fluorogenic substrate for chikungunya virus protease (nsP2) activity

一种用于检测基孔肯雅病毒蛋白酶(nsP2)活性的强效荧光底物

Makhaik, Sparsh; Rut, Wioletta; Choudhary, Shruti; Upadhyay, Tulsi; Hao, Chenzhou; Westberg, Michael; Bobst, Cedric; Yoo, Euna; Fejzo, Jasna; Lin, Michael Z; Bogyo, Matthew; Thompson, Paul; Drag, Marcin; Hardy, Jeanne A

A Robust Fluorogenic Substrate for Chikungunya Virus Protease (nsP2) Activity

一种用于检测基孔肯雅病毒蛋白酶 (nsP2) 活性的强效荧光底物

Makhaik, Sparsh; Rut, Wioletta; Choudhary, Shruti; Upadhyay, Tulsi; Hao, Chenzhou; Westberg, Michael; Bobst, Cedric; Yoo, Euna; Fejzo, Jasna; Lin, Michael Z; Bogyo, Matthew; Thompson, Paul; Drag, Marcin; Hardy, Jeanne A

An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations.

口服生物利用度高的 SARS-CoV-2 主蛋白酶抑制剂表现出更高的亲和力和更低的突变敏感性

Westberg Michael, Su Yichi, Zou Xinzhi, Huang Pinghan, Rustagi Arjun, Garhyan Jaishree, Patel Puja Bhavesh, Fernandez Daniel, Wu Yan, Hao Chenzhou, Lo Chieh-Wen, Karim Marwah, Ning Lin, Beck Aimee, Saenkham-Huntsinger Panatda, Tat Vivian, Drelich Aleksandra, Peng Bi-Hung, Einav Shirit, Tseng Chien-Te K, Blish Catherine, Lin Michael Z

Replication capacity and susceptibility of nirmatrelvir-resistant mutants to next-generation Mpro inhibitors in a SARS-CoV-2 replicon system

在SARS-CoV-2复制子系统中,耐尼马曲韦突变体的复制能力及其对新一代Mpro抑制剂的敏感性

Lo, Chieh-Wen; Kariv, Omri; Hao, Chenzhou; Gammeltoft, Karen Anbro; Bukh, Jens; Gottwein, Judith; Westberg, Michael; Lin, Michael Z; Einav, Shirit