日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PAXIS: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Phase 2 Study (Part 1) Followed by an Open-Label Period (Part 2) to Assess the Efficacy and Safety of Pacritinib in Patients with VEXAS Syndrome

PAXIS:一项随机、双盲、安慰剂对照、剂量探索性 II 期研究(第一部分)及后续开放标签期(第二部分),旨在评估帕克替尼治疗 VEXAS 综合征患者的疗效和安全性

Beck, David B; Heiblig, Maël; Savic, Sinisa; Ferrada, Marcela A; Mekinian, Arsène; Chowdhury, Onima; Hammond, Danielle; Weeks, Lachelle D; Gurnari, Carmelo; Kirino, Yohei; Georgin-Lavialle, Sophie; Buckley, Sarah A; Garcha, Raman; Harder, Bryan G; Koster, Matthew J

The mechanisms underlying the enhanced high-temperature properties of GRX-810

GRX-810增强高温性能的潜在机制

Smith, Timothy M; Kantzos, Christopher A; Harder, Bryan J; Bezold, Andreas; Heczko, Milan; Miao, Jiashi; Plummer, Gabriel; Mendelev, Mikhail I; Thompson, Aaron C; Puleo, Bernadette J; Whitt, Austin J; Stark, Andreas; Neumeier, Steffen; Gabb, Timothy P; Lawson, John W; Mills, Michael J; Gradl, Paul R

A 3D printable alloy designed for extreme environments

一种专为极端环境设计的3D打印合金

Smith, Timothy M; Kantzos, Christopher A; Zarkevich, Nikolai A; Harder, Bryan J; Heczko, Milan; Gradl, Paul R; Thompson, Aaron C; Mills, Michael J; Gabb, Timothy P; Lawson, John W

Pacritinib is a potent ACVR1 inhibitor with significant anemia benefit in patients with myelofibrosis

帕克替尼是一种强效的ACVR1抑制剂,可显著改善骨髓纤维化患者的贫血症状。

Oh, Stephen T; Mesa, Ruben A; Harrison, Claire N; Bose, Prithviraj; Gerds, Aaron T; Gupta, Vikas; Scott, Bart L; Kiladjian, Jean-Jacques; Lucchesi, Alessandro; Kong, Tim; Buckley, Sarah A; Tyavanagimatt, Shanthakumar; Harder, Bryan G; Roman-Torres, Karisse; Smith, Jennifer; Craig, Adam R; Mascarenhas, John; Verstovsek, Srdan

Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma

血脑屏障穿透和药物再利用方面的进展及其在改善胶质母细胞瘤治疗中的应用

Harder, Bryan G; Blomquist, Mylan R; Wang, Junwen; Kim, Anthony J; Woodworth, Graeme F; Winkles, Jeffrey A; Loftus, Joseph C; Tran, Nhan L

Arsenic Compromises Both p97 and Proteasome Functions

砷会损害p97和蛋白酶体的功能

Tillotson, Joseph; Zerio, Christopher J; Harder, Bryan; Ambrose, Andrew J; Jung, Kevin S; Kang, MinJin; Zhang, Donna D; Chapman, Eli

p62 links autophagy and Nrf2 signaling

p62连接自噬和Nrf2信号通路

Jiang, Tao; Harder, Bryan; Rojo de la Vega, Montserrat; Wong, Pak K; Chapman, Eli; Zhang, Donna D

Plant extracts of the family Lauraceae: a potential resource for chemopreventive agents that activate the nuclear factor-erythroid 2-related factor 2/antioxidant response element pathway.

樟科植物提取物:一种潜在的化学预防剂资源,可激活核因子-红细胞 2 相关因子 2/抗氧化反应元件通路

Shen Tao, Chen Xue-Mei, Harder Bryan, Long Min, Wang Xiao-Ning, Lou Hong-Xiang, Wondrak Georg T, Ren Dong-Mei, Zhang Donna D