日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Liganded LolCDE structures reveal a common substrate-LolE interaction guiding bacterial lipoprotein transport

配体结合的LolCDE结构揭示了一种常见的底物-LolE相互作用,该相互作用指导细菌脂蛋白的运输。

Szewczyk, Paul; Greene, Nicholas P; Symmons, Martyn F; Hardwick, Steven W; Koronakis, Vassilis

Oligomerisation of Ku from Mycobacterium tuberculosis promotes DNA synapsis

结核分枝杆菌Ku蛋白的寡聚化促进DNA突触形成

Zahid, Sayma; Baconnais, Sonia; Smith, Henrietta; Atwal, Saseela; Bates, Lucy; Read, Harriet; Chadda, Ankita; Morati, Florian; Bedwell, Tom; Stender, Emil G P; Walter, Joanne; Hardwick, Steven W; Westerlund, Fredrik; Galburt, Eric; Le Cam, Eric; Pyne, Alice; Mukamolova, Galina V; Chaplin, Amanda K

Cryo-EM structures of NHEJ assemblies with nucleosomes

核小体参与的NHEJ组装体的冷冻电镜结构

Hall, Chloe; Frit, Philippe; Kefala-Stavridi, Antonia; Pelletier, Amandine; Hardwick, Steven W; Amin, Himani; Bilyard, Matthew K; Maia De Oliviera, Taiana; Tariq, Ammarah; Zahid, Sayma; Chirgadze, Dimitri Y; Balasubramanian, Shankar; Meek, Katheryn; Ropars, Virginie; Charbonnier, Jean-Baptiste; Modesti, Mauro; Calsou, Patrick; Britton, Sébastien; Blundell, Tom L; Schalch, Thomas; Chaplin, Amanda K

Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ.

对Ku70/80和Pol X家族聚合酶在NHEJ中的相互作用的结构和功能见解

Frit Philippe, Amin Himani, Zahid Sayma, Barboule Nadia, Hall Chloe, Matharu Gurdip, Hardwick Steven W, Chauvat Jeanne, Britton Sébastien, Chirgadze Dima Y, Ropars Virginie, Charbonnier Jean-Baptiste, Calsou Patrick, Chaplin Amanda K

Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier

丙酮酸转运的分子基础及人类线粒体丙酮酸载体的抑制

Sichrovsky, Maximilian; Lacabanne, Denis; Ruprecht, Jonathan J; Rana, Jessica J; Stanik, Klaudia; Dionysopoulou, Mariangela; Sowton, Alice P; King, Martin S; Jones, Scott A; Cooper, Lee; Hardwick, Steven W; Paris, Giulia; Chirgadze, Dimitri Y; Ding, Shujing; Fearnley, Ian M; Palmer, Shane M; Pardon, Els; Steyaert, Jan; Leone, Vanessa; Forrest, Lucy R; Tavoulari, Sotiria; Kunji, Edmund R S

High-Throughput Identification and Characterization of LptDE-Binding Bicycle Peptides Using Phage Display and Cryo-EM

利用噬菌体展示和冷冻电镜技术对LptDE结合双环肽进行高通量鉴定和表征

Allyjaun, Shenaz; Dunbar, Emily; Hardwick, Steven W; Newell, Sarah; Holding, Finn; Rowland, Catherine E; St Denis, Megan A; Pellegrino, Simone; Arruda Bezerra, Gustavo; Bournakas, Nikolaos; Chirgadze, Dimitri Y; Cooper, Lee; Paris, Giulia; Lewis, Nick; Brown, Peter; Skynner, Michael J; Dawson, Michael J; Beswick, Paul; Hubbard, Julia; van den Berg, Bert; Newman, Hector

Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining.

两种不同的长程突触复合物促进DNA断裂通过非同源末端连接修复之前末端加工的不同方面

Buehl Christopher J, Goff Noah J, Hardwick Steven W, Gellert Martin, Blundell Tom L, Yang Wei, Chaplin Amanda K, Meek Katheryn

Unravelling the complexities of DNA-PK activation by structure-based mutagenesis

通过基于结构的诱变揭示DNA-PK激活的复杂性

Buehl, Christopher J; Goff, Noah J; Mikhova, Mariia; Hardwick, Steven W; Blundell, Thomas L; Modesti, Mauro; Schmidt, Jens C; Chaplin, Amanda; Meek, Katheryn

Multi-scale ensemble properties of the Escherichia coli RNA degradosome

大肠杆菌RNA降解体的多尺度集合特性

Dendooven, Tom; Paris, Giulia; Shkumatov, Alexander V; Islam, Md Saiful; Burt, Alister; Kubańska, Marta A; Yang, Tai Yuchen; Hardwick, Steven W; Luisi, Ben F

Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism

揭示RapZ介导的细菌氨基糖代谢调控的结构机制

Gonzalez, Grecia M; Durica-Mitic, Svetlana; Hardwick, Steven W; Moncrieffe, Martin C; Resch, Marcus; Neumann, Piotr; Ficner, Ralf; Görke, Boris; Luisi, Ben F