日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Impaired 11β-Hydroxysteroid Dehydrogenase Type 2 Activity in Kidney Disease Disrupts 11-Oxygenated Androgen Biosynthesis

肾脏疾病中11β-羟类固醇脱氢酶2型活性受损会破坏11-氧代雄激素的生物合成。

Tomkins, Maria; McDonnell, Tara; Cussen, Leanne; Sagmeister, Michael S; Oestlund, Imken; Shaheen, Fozia; Harper, Lorraine; Hardy, Rowan S; Taylor, Angela E; Gilligan, Lorna C; Arlt, Wiebke; McIlroy, Marie; de Freitas, Declan; Conlon, Peter; Magee, Colm; Denton, Mark; O'Seaghdha, Conall; Snoep, Jacky L; Storbeck, Karl-Heinz; Sherlock, Mark; O'Reilly, Michael W

Identification of anti-resorptive GPCRs by high-content imaging in human osteoclasts.

利用高内涵成像技术鉴定人破骨细胞中的抗骨吸收GPCR

Price Maria L, Wyatt Rachael A, Correia Joao, Areej Zakia, Hinds Maisie, Crastin Ana, Hardy Rowan S, Frost Morten, Gorvin Caroline M

G protein-coupled receptor 35 stimulation reduces osteoclast activity in primary human bone cells

G蛋白偶联受体35的刺激可降低原代人骨细胞中的破骨细胞活性。

Price, Maria L; Wyatt, Rachael A; Crastin, Ana; Jamaluddin, Aqfan; Hardy, Rowan S; Frost, Morten; Gorvin, Caroline M

Glucocorticoid excess alters metabolic rate and substrate utilisation via 11β-HSD1

糖皮质激素过量通过 11β-HSD1 改变代谢率和底物利用率

Heaselgrave, Samuel R; Heising, Silke; Morgan, Stuart A; Carthwright, David M; Sagmeister, Michael; Hardy, Rowan S; Doig, Craig L; Morton, Nicholas; Tsintzas, Kostas; Lavery, Gareth G

Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice

局部糖皮质激素合成调节小鼠屋尘螨诱导的气道高敏感性

Merk, Verena M; Phan, Truong San; Wiedmann, Alice; Hardy, Rowan S; Lavery, Gareth G; Brunner, Thomas

Oligonucleotide Therapeutics for Age-Related Musculoskeletal Disorders: Successes and Challenges

寡核苷酸疗法在治疗年龄相关肌肉骨骼疾病中的应用:成功与挑战

Nicholson, Thomas A; Sagmeister, Michael; Wijesinghe, Susanne N; Farah, Hussein; Hardy, Rowan S; Jones, Simon W

Bench to Bedside: Modelling Inflammatory Arthritis

从实验室到临床:炎症性关节炎建模

Chidomere, Chiamaka I; Wahid, Mussarat; Kemble, Samuel; Chadwick, Caroline; Thomas, Richard; Hardy, Rowan S; McGettrick, Helen M; Naylor, Amy J

Cortisol excess in chronic kidney disease - A review of changes and impact on mortality

慢性肾脏病中皮质醇过量——变化及其对死亡率的影响综述

Sagmeister, Michael S; Harper, Lorraine; Hardy, Rowan S

Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis

急性呼吸窘迫综合征与肺泡巨噬细胞吞噬功能受损有关。

Mahida, Rahul Y; Scott, Aaron; Parekh, Dhruv; Lugg, Sebastian T; Hardy, Rowan S; Lavery, Gareth G; Matthay, Michael A; Naidu, Babu; Perkins, Gavin D; Thickett, David R

Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids

局部类固醇激活是治疗性糖皮质激素发挥抗炎作用的关键介质。

Fenton, Chloe; Martin, Claire; Jones, Rachel; Croft, Adam; Campos, Joana; Naylor, Amy J; Taylor, Angela E; Chimen, Myriam; Cooper, Mark; Lavery, Gareth G; Raza, Karim; Hardy, Rowan S