日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

AZ14289671 is a highly selective and blood-brain barrier penetrant irreversible TKI that targets EGFRExon20 insertions.

AZ14289671 是一种高选择性且能穿透血脑屏障的不可逆 TKI,靶向 EGFRExon20 插入

Swaih Aisha M, Talbot Sara, Savoca Adriana, Thorpe Hannah, Flemington Vikki, Phillips Benjamin, Colclough Nicola, McCoull William, Radeva Veronika, Hargreaves David, Packer Martin J, Felisberto-Rodrigues Catarina, Thomson Clare, Orme Jonathan P, Deane Carly, Smith Aaron, Johnström Peter, Schou Magnus, McWilliams Lisa, Davey Paul, Enget Marianne, O'Neill Daniel, Cosulich Sabina, Floc'h Nicolas

Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen

从DNA编码化合物库筛选中鉴定和评价与Bfl-1 Cys55位点可逆共价结合的化合物

Lucas, Simon C C; Blackwell, J Henry; Börjesson, Ulf; Hargreaves, David; Milbradt, Alexander G; Ahmed, Samiyah; Bostock, Mark J; Guerot, Carine; Gohlke, Andrea; Kinzel, Olaf; Lamb, Michelle L; Selmi, Nidhal; Stubbs, Christopher J; Su, Nancy; Su, Qibin; Luo, Haiou; Xiong, Ting; Zuo, Xiaoqian; Bazzaz, Sana; Bienstock, Corey; Centrella, Paolo A; Denton, Kyle E; Gikunju, Diana; Guié, Marie-Aude; Guilinger, John P; Hupp, Christopher; Keefe, Anthony D; Satoh, Takashi; Zhang, Ying; Rivers, Emma L

Internal Joint Stabilization for Recurrent Nontraumatic Elbow Dislocation in a Skeletally Immature Patient

骨骼未成熟患者复发性非创伤性肘关节脱位的内固定术

Stoneham, Adam C S; Lindisfarne, Edward; Hargreaves, David; Heifner, John J

Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1

刚性蛋白质-蛋白质相互作用抑制剂的设计使得靶向不可成药的Mcl-1成为可能。

Hargreaves, David; Carbajo, Rodrigo J; Bodnarchuk, Michael S; Embrey, Kevin; Rawlins, Philip B; Packer, Martin; Degorce, Sébastien L; Hird, Alexander W; Johannes, Jeffrey W; Chiarparin, Elisabetta; Schade, Markus

Not getting in too deep: A practical deep learning approach to routine crystallisation image classification

不深入探讨:一种用于常规结晶图像分类的实用深度学习方法

Milne, Jamie; Qian, Chen; Hargreaves, David; Wang, Yinhai; Wilson, Julie

Predicting the Effect of Chemical Factors on the pH of Crystallization Trials

预测化学因素对结晶试验pH值的影响

Wilson, Julie; Ristic, Marko; Kirkwood, Jobie; Hargreaves, David; Newman, Janet

Analysis of crystallization data in the Protein Data Bank

对蛋白质数据库中结晶数据的分析

Kirkwood, Jobie; Hargreaves, David; O'Keefe, Simon; Wilson, Julie

Arthroscopic thermal capsular shrinkage for palmar midcarpal instability

掌侧腕中关节不稳的关节镜下热缩关节囊术

Hargreaves, David G

Biomimetic silicification of demineralized hierarchical collagenous tissues

脱矿层级胶原组织的仿生硅化

Li-Na Niu #, Kai Jiao #, Heonjune Ryou, Anibal Diogenes, Cynthia K Y Yiu, Annalisa Mazzoni, Ji-Hua Chen, Dwayne D Arola, Kenneth M Hargreaves, David H Pashley, Franklin R Tay

A manual low-cost protein-crystallization plate jig for in situ diffraction in the home laboratory

一种用于家庭实验室原位衍射的低成本手动蛋白质结晶板夹具

Hargreaves, David