Harhaj相关文献与解析，生知库 | 链接生命科学的每一步

Suklabaidya Sujit, Mohanty Suchitra, Reider Irene E, White Jesse, Colter Dominic, McCormick Sarah M, Shembade Noula, Choi Young Bong, Norbury Christopher C, Harhaj Edward W

信号转导

STING

TAX1BP1

发表日期：2026

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Spleen Tyrosine Kinase (SYK) is Necessary for cGAS-STING Signaling in Müller Glia and Visual Function Deficits in Diabetic Mice

脾酪氨酸激酶（SYK）是糖尿病小鼠Müller胶质细胞中cGAS-STING信号传导和视觉功能缺陷所必需的

期刊:Glia

影响因子:5.1

doi:10.1002/glia.70155

Yerlikaya, Esma I; Sunilkumar, Siddharth; Subrahmanian, Sandeep M; Toro, Allyson L; Yeager, Clay T; Shaikh, Kashif A; Harhaj, Edward W; Barber, Alistair J; Dennis, Michael D

Phosphorylation of the selective autophagy receptor TAX1BP1 by TBK1 and IKBKE/IKKi promotes ATG8-family protein-dependent clearance of MAVS aggregates

TBK1 和 IKBKE/IKKi 对选择性自噬受体 TAX1BP1 的磷酸化促进 ATG8 家族蛋白依赖性的 MAVS 聚集体清除

期刊:Autophagy

影响因子:14.6

doi:10.1080/15548627.2024.2394306

Jesse White ,Young Bong Choi ,Jiawen Zhang ,Mai Tram Vo ,Chaoxia He ,Kashif Shaikh ,Edward W Harhaj

REDD1 expression in podocytes facilitates renal inflammation and pyroptosis in streptozotocin-induced diabetic nephropathy.

REDD1 在足细胞中的表达促进链脲佐菌素诱导的糖尿病肾病中的肾脏炎症和细胞焦亡

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-025-07396-4

Sunilkumar Siddharth, Subrahmanian Sandeep M, Yerlikaya Esma I, Toro Allyson L, Harhaj Edward W, Kimball Scot R, Dennis Michael D

HTLV-1 Tax induces PINK1-Parkin-dependent mitophagy to mitigate activation of the cGAS-STING pathway.

HTLV-1 Tax 诱导 PINK1-Parkin 依赖性线粒体自噬，以减轻 cGAS-STING 通路的激活

期刊:

影响因子:

doi:10.1101/2025.03.15.643451

Mohanty Suchitra, Suklabaidya Sujit, Mnatsakanyan Nelli, Jacobson Steven, Harhaj Edward W

The tyrosine kinase KDR is essential for the survival of HTLV-1-infected T cells by stabilizing the Tax oncoprotein

酪氨酸激酶KDR通过稳定Tax癌蛋白，对HTLV-1感染的T细胞的存活至关重要。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-024-49737-5

Suchitra Mohanty ，Sujit Suklabaidya ，Alfonso Lavorgna ，Takaharu Ueno ，Jun-Ichi Fujisawa ，Nyater Ngouth ，Steven Jacobson ，Edward W Harhaj

ZFAND6 promotes TRAF2-dependent mitophagy to restrain cGAS-STING signaling

ZFAND6促进TRAF2依赖性线粒体自噬以抑制cGAS-STING信号传导

期刊:iScience

影响因子:4.6

doi:10.1016/j.isci.2024.111544

Kashif Shaikh ,Melissa Bowman ,Sarah M McCormick ,Linlin Gao ,Jiawen Zhang ,Jesse White ,John Tawil ,Arun Kapoor ,Ravit Arav-Boger ,Christopher C Norbury ,Edward W Harhaj

ZFAND6 promotes TRAF2-dependent mitophagy to restrain cGAS-STING signaling

ZFAND6促进TRAF2依赖性线粒体自噬以抑制cGAS-STING信号传导

期刊:

影响因子:4.6

doi:PMC11731517

Kashif Shaikh，Melissa Bowman，Sarah M McCormick，Linlin Gao，Jiawen Zhang，Jesse White，John Tawil，Arun Kapoor，Ravit Arav-Boger，Christopher C Norbury，Edward W Harhaj

Phosphorylation of aryl hydrocarbon receptor interacting protein by TBK1 negatively regulates IRF7 and the type I interferon response

TBK1 对芳烃受体相互作用蛋白的磷酸化作用负调控 IRF7 和 I 型干扰素反应。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2023.105525

Kazzaz, Sarah A; Shaikh, Kashif A; White, Jesse; Zhou, Qinjie; Powell, Wade H; Harhaj, Edward W

The aryl hydrocarbon receptor-interacting protein in cancer and immunity: Beyond a chaperone protein for the dioxin receptor

芳烃受体相互作用蛋白在癌症和免疫中的作用：不仅仅是二恶英受体的分子伴侣蛋白

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2024.107157

Kazzaz, Sarah A; Tawil, John; Harhaj, Edward W

Negative feedback regulation of STING signaling by TAX1BP1-directed Golgiphagy.

TAX1BP1 介导的高尔基吞噬作用对 STING 信号传导的负反馈调节。

Spleen Tyrosine Kinase (SYK) is Necessary for cGAS-STING Signaling in Müller Glia and Visual Function Deficits in Diabetic Mice

脾酪氨酸激酶（SYK）是糖尿病小鼠Müller胶质细胞中cGAS-STING信号传导和视觉功能缺陷所必需的

Phosphorylation of the selective autophagy receptor TAX1BP1 by TBK1 and IKBKE/IKKi promotes ATG8-family protein-dependent clearance of MAVS aggregates

TBK1 和 IKBKE/IKKi 对选择性自噬受体 TAX1BP1 的磷酸化促进 ATG8 家族蛋白依赖性的 MAVS 聚集体清除

REDD1 expression in podocytes facilitates renal inflammation and pyroptosis in streptozotocin-induced diabetic nephropathy.

REDD1 在足细胞中的表达促进链脲佐菌素诱导的糖尿病肾病中的肾脏炎症和细胞焦亡

HTLV-1 Tax induces PINK1-Parkin-dependent mitophagy to mitigate activation of the cGAS-STING pathway.

HTLV-1 Tax 诱导 PINK1-Parkin 依赖性线粒体自噬，以减轻 cGAS-STING 通路的激活

The tyrosine kinase KDR is essential for the survival of HTLV-1-infected T cells by stabilizing the Tax oncoprotein

酪氨酸激酶KDR通过稳定Tax癌蛋白，对HTLV-1感染的T细胞的存活至关重要。

ZFAND6 promotes TRAF2-dependent mitophagy to restrain cGAS-STING signaling

ZFAND6促进TRAF2依赖性线粒体自噬以抑制cGAS-STING信号传导

ZFAND6 promotes TRAF2-dependent mitophagy to restrain cGAS-STING signaling

ZFAND6促进TRAF2依赖性线粒体自噬以抑制cGAS-STING信号传导

Phosphorylation of aryl hydrocarbon receptor interacting protein by TBK1 negatively regulates IRF7 and the type I interferon response

TBK1 对芳烃受体相互作用蛋白的磷酸化作用负调控 IRF7 和 I 型干扰素反应。

The aryl hydrocarbon receptor-interacting protein in cancer and immunity: Beyond a chaperone protein for the dioxin receptor

芳烃受体相互作用蛋白在癌症和免疫中的作用：不仅仅是二恶英受体的分子伴侣蛋白