日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo

引导RNA 3'末端区域中磷酸二酯骨架的存在(而非核碱基的存在)是RISC在体外和体内装载和靶标切割所必需的。

O'Reilly, Daniel; Furgal, Raymond C; Ross, Vella M; Luu, Eric; Gross, Katherine Y; Hariharan, Vignesh; Summers, Ashley; Cooper, David; Allen, Sarah; Dahlke, Christopher; Rachid, Mohamad Omar; Chan, Io Long; Fakih, Hassan H; Alterman, Julia F; Echeverria, Dimas; Watts, Jonathan K; Khvorova, Anastasia

Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy.

对影响完全化学修饰的siRNA功效的siRNA和mRNA特征进行系统分析

Davis Sarah M, Hildebrand Samuel, MacMillan Hannah J, Monopoli Kathryn R, Buchwald Julianna, Sousa Jacquelyn, Cooper David, Ly Socheata, Echeverria Dimas, McHugh Nicholas, Ferguson Chantal, Coles Andrew, Hariharan Vignesh N, O'Reilly Daniel, Tang Qi, Furgal Raymond, Yamada Ken, Alterman Julia F, Gilbert James W, Knox Emily, Pineda Yamilett, Weston Caitlyn N, Baer Christina E, Pai Athma A, Khvorova Anastasia

Systematic Evaluation of Position-Specific Tolerability of Seven Backbone and Ribose Modifications in Fully Chemically Stabilized siRNAs

对七种骨架和核糖修饰在完全化学稳定的siRNA中的位置特异性耐受性进行系统评价

O'Reilly, Daniel; Furgal, Raymond; Hariharan, Vignesh; Lochmann, Clemens; Cooper, David; Echeverria, Dimas; Khvorova, Anastasia

Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model

单次注射靶向 MECP2 的治疗性二价 siRNA 可使 MECP2 重复小鼠模型免于死亡一年。

Hariharan, Vignesh N; Summers, Ashley; Clipperton-Allen, Amy E; Caiazzi, Jillian; Hildebrand, Samuel R; O'Reilly, Daniel; Tang, Qi; Kennedy, Zachary; Echeverria, Dimas; McHugh, Nicholas; Cooper, David; Souza, Jacqueline; Ferguson, Chantal; Bogdanik, Laurent; Coenraads, Monica; Khvorova, Anastasia

Retrospective analysis of digital health technology effectiveness in cardiac rehabilitation

对数字健康技术在心脏康复中有效性的回顾性分析

Hariharan, Vignesh Krishna; Rajan, Vishnu Poovathinkal; Sharma, Sorabh; Koppolu, Shanmukha; Eshu, Shruthi Alekere; Pavani, Nutheti

Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA

磷脂酰胆碱头部基团的化学性质会改变脂质偶联siRNA在肝外的积累。

Hariharan, Vignesh N; Nakamura, Takahiro; Shin, Minwook; Tang, Qi; Sontakke, Vyankat; Caiazzi, Jillian; Hildebrand, Samuel; Khvorova, Anastasia; Yamada, Ken

Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease

二价siRNA介导的MSH3沉默可阻断亨廷顿病小鼠模型中的体细胞重复序列扩增

O'Reilly, Daniel; Belgrad, Jillian; Ferguson, Chantal; Summers, Ashley; Sapp, Ellen; McHugh, Cassandra; Mathews, Ella; Boudi, Adel; Buchwald, Julianna; Ly, Socheata; Moreno, Dimas; Furgal, Raymond; Luu, Eric; Kennedy, Zachary; Hariharan, Vignesh; Monopoli, Kathryn; Yang, X William; Carroll, Jeffery; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

Antiplatelet Treatment Patterns and Outcomes for Secondary Stroke Prevention in the United Kingdom

英国抗血小板治疗模式及二级卒中预防结果

Liu, Xuejun; Jiang, Jenny; Li, Danshi; Horrow, Jay; Tamada, Hiroshi; Kahl, Anja; Hariharan, Vignesh; Avinav, Ankur; Li, Xiaoyan

Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles.

将二十二碳酸与 siRNA 结合,可实现功能性且安全的递送至骨骼肌和心肌

Biscans Annabelle, Caiazzi Jillian, McHugh Nicholas, Hariharan Vignesh, Muhuri Manish, Khvorova Anastasia