日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers of the human secretin receptor in live cells

从活细胞中人促胰液素受体短寿命GPCR寡聚体的原子级四级结构揭示其机制

Stoneman, Michael R; Killeen, Thomas D; Yokoi, Koki; Biener, Gabriel; Bista, Sanam; Adhikari, Dhruba P; Rahman, Sadia; Harikumar, Kaleeckal G; Miller, Laurence J; Popa, Ionel; Raicu, Valerică

Impact of secretin receptor homo-dimerization on natural ligand binding

促胰液素受体同源二聚化对天然配体结合的影响

Harikumar, Kaleeckal G; Piper, Sarah J; Christopoulos, Arthur; Wootten, Denise; Sexton, Patrick M; Miller, Laurence J

Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers in live cells

从活细胞中短寿命GPCR寡聚体的原子级四级结构揭示其机制

Stoneman, Michael R; Yokoi, Koki; Biener, Gabriel; Killeen, Thomas D; Adhikari, Dhruba P; Rahman, Sadia; Harikumar, Kaleeckal G; Miller, Laurence J; Raicu, Valerică

Secretin Amino-Terminal Structure-Activity Relationships and Complementary Mutagenesis at the Site of Docking to the Secretin Receptor

促胰液素氨基末端结构-活性关系及与促胰液素受体结合位点的互补突变

Milburn, Juliana E; Harikumar, Kaleeckal G; Piper, Sarah J; Raval, Sweta; Christopoulos, Arthur; Wootten, Denise; Sexton, Patrick M; Miller, Laurence J

Structure of an AMPK complex in an inactive, ATP-bound state

处于非活性、ATP结合状态的AMPK复合物的结构

Yan, Yan; Mukherjee, Somnath; Harikumar, Kaleeckal G; Strutzenberg, Timothy S; Zhou, X Edward; Suino-Powell, Kelly; Xu, Ting-Hai; Sheldon, Ryan D; Lamp, Jared; Brunzelle, Joseph S; Radziwon, Katarzyna; Ellis, Abigail; Novick, Scott J; Vega, Irving E; Jones, Russell G; Miller, Laurence J; Xu, H Eric; Griffin, Patrick R; Kossiakoff, Anthony A; Melcher, Karsten

Single-molecule FRET imaging of GPCR dimers in living cells

利用单分子FRET成像技术对活细胞中的GPCR二聚体进行成像

Asher, Wesley B; Geggier, Peter; Holsey, Michael D; Gilmore, Grant T; Pati, Avik K; Meszaros, Jozsef; Terry, Daniel S; Mathiasen, Signe; Kaliszewski, Megan J; McCauley, Mitchell D; Govindaraju, Alekhya; Zhou, Zhou; Harikumar, Kaleeckal G; Jaqaman, Khuloud; Miller, Laurence J; Smith, Adam W; Blanchard, Scott C; Javitch, Jonathan A

Environment-Sensitive Fluorescence of 7-Nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-Labeled Ligands for Serotonin Receptors

7-硝基苯并-2-氧杂-1,3-二唑-4-基(NBD)标记的血清素受体配体的环境敏感荧光

Sarkar, Parijat; Harikumar, Kaleeckal G; Rawat, Satinder S; Das, Sanjib; Chakraborty, Tushar K; Chattopadhyay, Amitabha

Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics

胆囊收缩素在营养连续体中的作用:生理学和潜在治疗

Miller, Laurence J; Harikumar, Kaleeckal G; Wootten, Denise; Sexton, Patrick M

Rational development of a high-affinity secretin receptor antagonist

合理开发高亲和力促胰液素受体拮抗剂

Dong, Maoqing; Harikumar, Kaleeckal G; Raval, Sweta R; Milburn, Juliana E; Clark, Carolyn; Alcala-Torano, Rafael; Mobarec, Juan C; Reynolds, Christopher A; Ghirlanda, Giovanna; Christopoulos, Arthur; Wootten, Denise; Sexton, Patrick M; Miller, Laurence J

Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus

GPCR异源二聚体对信号传导的修饰及其对X连锁肾性尿崩症的影响

Ng, Hans K H; Harikumar, Kaleeckal G; Miller, Laurence J; Chow, Billy K C