日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A mismatch in enzyme-redox partnerships underlies divergent cytochrome P450 activities between human hepatocytes and microsomes

人肝细胞和微粒体中细胞色素P450活性差异的根本原因是酶-氧化还原相互作用的不匹配。

Bapiro, Tashinga E; Martin, Scott; Blacker, Thomas S; Wilkinson, Stephen D; Orton, Alexandra L; Hariparsad, Niresh; Jones, Rhys D O; Duchen, Michael R; Harlfinger, Stephanie

Beyond-Rule-of-Five Compounds Are Not Different: In Vitro-In Vivo Extrapolation of Female CD-1 Mouse Clearance Based on Merck Healthcare KGaA Compound Set

超越五规则的化合物并无不同:基于默克医疗保健集团化合物集的雌性CD-1小鼠清除率的体外-体内外推

Maurer, Christine K; Fang, Zhizhou; Duevel, Heide M; Harlfinger, Stephanie; Petersson, Carl

Use of new approach methodology for hepatic safety assessment of covalent inhibitor drug candidates.

采用新的方法对共价抑制剂候选药物进行肝脏安全性评价

Amberntsson Sara, Foster Alison J, Chouhan Bhavik, Wilkinson Stephen, Harlfinger Stephanie, Smith Graham, Kettle Jason G, Niedbala Michael, Kavanagh Stefan, Williams Dominic P

Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition

通过对体内MAT2A抑制后系统通路扰动进行多组学表征,进行机制安全性评估

Fogal, Valentina; Michopoulos, Filippos; Jarnuczak, Andrew F; Hamza, Ghaith M; Harlfinger, Stephanie; Davey, Paul; Hulme, Heather; Atkinson, Stephen J; Gabrowski, Piotr; Cheung, Tony; Grondine, Michael; Hoover, Clare; Rose, Jonathan; Bray, Chandler; Foster, Alison J; Askin, Sean; Majumder, Muntasir Mamun; Fitzpatrick, Paul; Miele, Eric; Macdonald, Ruth; Keun, Hector C; Coen, Muireann