日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Insights derived from testing a library of per- and polyfluoroalkyl substances (PFAS) in a battery of new approach methods (NAMs)

通过对一系列新型检测方法(NAMs)中全氟和多氟烷基物质(PFAS)库进行测试,获得了以下见解

Patlewicz, Grace; Judson, Richard; Paul Friedman, Katie; Wetmore, Barbara A; DeVito, Michael J; Harrill, Joshua A; Carstens, Kelly E; Houck, Keith A; Wambaugh, John F; Padilla, Stephanie; Britton, Katy N; Shafer, Timothy J; Degitz, Sigmund; Nyffeler, Jo; Kreutz, Anna; Richard, Ann M; Williams, Antony J; Coutros, Katherine; Hornung, Michael W; Cowden, John; Everett, Logan J; Willis, Clinton M; Smeltz, Marci G; Clifton, M Scott; Feshuk, Madison; Wall, Jonathan T; Sayre, Risa R; Brown, Jason; Thomas, Russell S

Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening

将转录组学和靶向新方法整合到分层框架中,用于化学生物活性筛选

Rogers, Jesse D; Bundy, Joseph L; Harrill, Joshua A; Judson, Richard J; Paul-Friedman, Katie; Everett, Logan J

Phenotypic Profiling of 6PPD, 6PPD-quinone and Structurally Diverse Antiozonants in RTgill-W1 Cells Using the Cell Painting Assay

利用细胞涂染法对 6PPD、6PPD-醌和结构多样的抗臭氧剂在 RTgill-W1 细胞中的表型进行分析

Harris, Felix R; Jankowski, Mark D; Villeneuve, Daniel L; Harrill, Joshua A

Bridging in vitro and in vivo inhalation toxicity: Volatile organic compounds elicit similar transcriptomic points of departure in human airway cells and mouse respiratory tract

体外和体内吸入毒性研究的桥梁:挥发性有机化合物在人呼吸道细胞和鼠呼吸道中引发相似的转录组学变化

Jackson, Thomas W; Murray, Jessica R; Schacht, Celia M; Evansky, Paul A; Monsees, Michael E; Harrill, Joshua A; Gilmour, M Ian; Johnstone, Andrew F; Williams, Wanda C; Grindstaff, Rachel D; Schladweiler, Mette C; Vance, Samuel A; Gavett, Stephen H

Assessing the impact of in vitro xenobiotic metabolism on estrogenic chemical bioactivity in high-throughput profiling assays

利用高通量分析法评估体外外源性物质代谢对雌激素化学生物活性的影响

Jurgelewicz, Amanda; Breaux, Kristen; Willis, Clinton M; Harris, Felix R; Byrd, Gabrielle; Witten, Joshua; Haggard, Derik E; Deisenroth, Chad; Harrill, Joshua A

The OASIS Consortium: integrating multi-omics technologies to transform chemical safety assessment

OASIS联盟:整合多组学技术以变革化学品安全评估

Rouquié, David; Bender, Andreas; Cheah, Jaime; Crute, Christine E; Dalmas, Deidre; Ewald, Jessica; Fullerton, Aaron; Harrill, Joshua A; Kadri, Sabah; Kleinstreuer, Nicole; Kramer, Nynke; LaRocca, Jessica; Mitchell, Constance A; Seal, Srijit; Singh, Shantanu; Carpenter, Anne E

Zebrafish cell lines and high-throughput transcriptomics: advancing in vitro and bioinformatics methods for supporting environmental risk assessment

斑马鱼细胞系和高通量转录组学:推进体外和生物信息学方法以支持环境风险评估

Schumann, Peter G; Bundy, Joseph; Haggard, Derik E; Everett, Logan; Harrill, Joshua A; Harris, Felix; Ryoo, David; Collins, Jacob; Rivetti, Claudia; Campos, Bruno; Hodges, Geoff; LaLone, Carlie A

TempO-seq and RNA-seq gene expression levels are highly correlated for most genes: A comparison using 39 human cell lines

TempO-seq 和 RNA-seq 基因表达水平对大多数基因而言高度相关:一项使用 39 种人类细胞系的比较研究

Word, Laura J; Willis, Clinton M; Judson, Richard S; Everett, Logan J; Davidson-Fritz, Sarah E; Haggard, Derik E; Chambers, Bryant A; Rogers, Jesse D; Bundy, Joseph L; Shah, Imran; Sipes, Nisha S; Harrill, Joshua A

A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS)

全氟和多氟烷基物质(PFAS)体外检测点与人体血液浓度的比较

Judson, Richard S; Smith, Doris; DeVito, Michael; Wambaugh, John F; Wetmore, Barbara A; Paul Friedman, Katie; Patlewicz, Grace; Thomas, Russell S; Sayre, Risa R; Olker, Jennifer H; Degitz, Sigmund; Padilla, Stephanie; Harrill, Joshua A; Shafer, Timothy; Carstens, Kelly E

Signature analysis of high-throughput transcriptomics screening data for mechanistic inference and chemical grouping

利用高通量转录组学筛选数据进行特征分析,以进行机制推断和化学分组

Harrill, Joshua A; Everett, Logan J; Haggard, Derik E; Word, Laura J; Bundy, Joseph L; Chambers, Bryant; Harris, Felix; Willis, Clinton; Thomas, Russell S; Shah, Imran; Judson, Richard