日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Atlas of one-carbon metabolism in conventional and germ-free mice reveals folate as a key determinant of biochemical pathways

常规小鼠和无菌小鼠的一碳代谢图谱揭示叶酸是生化途径的关键决定因素

Williams, Jonathan; Kim, Woo Sung; Danner, Rebecca; Cho, Juyeong; Silva, Bianca F; Harris, David A; Rey, Federico E; Chaudhari, Snehal N

Presymptomatic pharmacological inhibition of mGluR5 improves survival in a mouse model of prion diseases.

在朊病毒疾病小鼠模型中,症状前通过药物抑制 mGluR5 可提高生存率。

Wang Yue, Mohammadi Behnam, Hartmann Christiane, Hartmann Kristin, Thies Edda, Matamoros-Angles Andreu, Fang Cheng, Harris David A, Tatzelt Jörg, Altmeppen Hermann C, Sepulveda-Falla Diego, Strittmatter Stephen M, Glatzel Markus, Krasemann Susanne

Membrane-anchored PrPSc is the trigger for prion synaptotoxicity

膜锚定型PrPSc是朊病毒突触毒性的触发因子

Gatdula, Jean R P; Mercer, Robert C C; Alepuz Guillen, Jose Andres; Vultaggio, Janelle S; Harris, David A

Rational Design and Evaluation of Novel TGR5 Agonists for Diabetes

糖尿病新型TGR5激动剂的合理设计与评价

Bhimanwar, Rachana S; Detwiler, Zachary; Zhu, Jinge G; Saghafi, Samuel T; Winder, Carolyn A; Davis, Dawn Belt; Mittal, Amit; Sharma, Vikas; Harris, David A; Chaudhari, Snehal N

Enhanced lysosomal activity prevents infection with PrP(Sc) and the seeding activity of α-synuclein & tau prions

溶酶体活性增强可阻止 PrP(Sc) 感染以及 α-突触核蛋白和 tau 朊病毒的播散活性。

Mercer, Robert C C; Le, Nhat T T; Mirza-Romero, Nadia A; Orbe, Isabel C; Flaherty, Erin; DeFranco, Joseph P; Lavigna, Giada; Gatdula, Jean R P; Fraser, Douglas G; Sundaravadivelu, Aravind; Vultaggio, Janelle S; Beeler, Aaron B; Chiesa, Roberto; Telling, Glenn C; Harris, David A

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease.

中枢神经系统中生长分化因子 15 升高与亚历山大病患儿生长发育迟缓有关。

Hagemann Tracy L, Sonsalla Michelle M, Luzinski Cora, Zacahua Fernando, Harris David A, Lamming Dudley W, Messing Albee

Sleeve gastrectomy protects lean mice from future obesity

袖状胃切除术可保护瘦鼠免于未来肥胖。

Moscalu, Andrei; Babygirijia, Reji; Mathew, Twinkle; Chaudhari, Snehal N; Zhang, David; Zhou, Lei; Sheu, Eric G; Harris, David A

Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs

化学组学流程能够发现朊病毒突触毒性通路和抑制药物

Le, Nhat T T; Mercer, Robert C C; Fang, Cheng; Sundaravadivelu, Aravind; Labadorf, Adam T; Lin, Weiwei; Kwan, Julian; Blum, Benjamin; Emili, Andrew; Harris, David A

Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategy

利用库鲁病保护性朊病毒蛋白变体G127V的显性负效应作为一种新型治疗策略

Gatdula, Jean R P; Orbe, Isabel C; Tolton, Samantha G; Saunders, Linnea M; Vultaggio, Janelle S; Mercer, Robert C C; Bartz, Jason C; Telling, Glenn C; Eraña, Hasier; Castilla, Joaquín; Harris, David A

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease.

在阿尔茨海默病 3xTg 小鼠模型中,禁食是实现热量限制诸多益处的必要条件

Babygirija Reji, Han Jessica H, Sonsalla Michelle M, Matoska Ryan, Calubag Mariah F, Green Cara L, Tobon Anna, Yeh Chung-Yang, Vertein Diana, Schlorf Sophia, Illiano Julia, Liu Yang, Grunow Isaac, Rigby Michael J, Puglielli Luigi, Harris David A, Denu John M, Lamming Dudley W