Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A
染色体碎裂相关21号染色体扩增通过DYRK1A的靶向过表达调控MPN向急变期转化
期刊:Nature Genetics
影响因子:31.7
doi:10.1038/s41588-025-02190-6
Charlotte K Brierley #,Bon Ham Yip #,Giulia Orlando #,Jeremy Wen,Sean Wen,Harsh Goyal,Max Levine,G Maria Jakobsdottir,Avraam Tapinos,Alex J Cornish,Antonio Rodriguez-Romera,Alba Rodriguez-Meira,Matthew Bashton,Angela Hamblin,Sally Ann Clark,Joseph C Hamley,Olivia Fox,Madalina Giurgiu,Jennifer O'Sullivan,Lauren Murphy,Assunta Adamo,Aude Anais Olijnik,Anitria Cotton,Emily Hendrix,Shilpa Narina,Shondra M Pruett-Miller,Amir Enshaei,Claire Harrison,Mark Drummond,Steven Knapper,Ayalew Tefferi,Iléana Antony-Debré,James Davies,Anton G Henssen,Supat Thongjuea,David C Wedge,Stefan N Constantinescu,Elli Papaemmanuil,Bethan Psaila,John D Crispino,Adam J Mead
