日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment

奥沙尼喹耐药基因在旧大陆曼氏血吸虫中广泛存在,且早于该药物的推广应用。

Chevalier, Frédéric D; Le Clec'h, Winka; McDew-White, Marina; Menon, Vinay; Guzman, Meghan A; Holloway, Stephen P; Cao, Xiaohang; Taylor, Alexander B; Kinung'hi, Safari; Gouvras, Anouk N; Webster, Bonnie L; Webster, Joanne P; Emery, Aidan M; Rollinson, David; Garba Djirmay, Amadou; Al Mashikhi, Khalid M; Al Yafae, Salem; Idris, Mohamed A; Moné, Hélène; Mouahid, Gabriel; Hart, P John; LoVerde, Philip T; Anderson, Timothy J C

Mycoplasma pneumoniae Community-Acquired Respiratory Distress Syndrome Toxin Uses a Novel KELED Sequence for Retrograde Transport and Subsequent Cytotoxicity.

肺炎支原体社区获得性呼吸窘迫综合征毒素利用新型 KELED 序列进行逆行运输和随后的细胞毒性

Ramasamy Kumaraguruparan, Balasubramanian Sowmya, Manickam Krishnan, Pandranki Lavanya, Taylor Alexander B, Hart P John, Baseman Joel B, Kannan T R

Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts

野生型和突变型α-突触核蛋白聚集的局部诱导揭示了其沿神经解剖通路传播的现象

Ayers, Jacob I; Riffe, Cara J; Sorrentino, Zachary A; Diamond, Jeffrey; Fagerli, Eric; Brooks, Mieu; Galaleldeen, Ahmad; Hart, P John; Giasson, Benoit I

Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.

从结构和酶学角度深入了解血吸虫寄生虫药物治疗的物种特异性耐药性

Taylor Alexander B, Roberts Kenneth M, Cao Xiaohang, Clark Nathaniel E, Holloway Stephen P, Donati Enrica, Polcaro Chiara M, Pica-Mattoccia Livia, Tarpley Reid S, McHardy Stanton F, Cioli Donato, LoVerde Philip T, Fitzpatrick Paul F, Hart P John

Independent origins of loss-of-function mutations conferring oxamniquine resistance in a Brazilian schistosome population

巴西血吸虫群体中导致奥沙尼喹耐药性的功能丧失突变的独立起源

Chevalier, Frédéric D; Le Clec'h, Winka; Eng, Nina; Rugel, Anastasia R; Assis, Rafael Ramiro de; Oliveira, Guilherme; Holloway, Stephen P; Cao, Xiaohang; Hart, P John; LoVerde, Philip T; Anderson, Timothy J C

Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS

可传播的错误折叠SOD1的不同构象将人类SOD1-FALS与其他类型的家族性和散发性ALS区分开来。

Ayers, Jacob I; Diamond, Jeffrey; Sari, Adriana; Fromholt, Susan; Galaleldeen, Ahmad; Ostrow, Lyle W; Glass, Jonathan D; Hart, P John; Borchelt, David R

Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine

抗血吸虫药物奥沙尼喹对映体的结构和功能表征

Taylor, Alexander B; Pica-Mattoccia, Livia; Polcaro, Chiara M; Donati, Enrica; Cao, Xiaohang; Basso, Annalisa; Guidi, Alessandra; Rugel, Anastasia R; Holloway, Stephen P; Anderson, Timothy J C; Hart, P John; Cioli, Donato; LoVerde, Philip T

Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1

内含子脱分支酶Dbr1识别套索RNA的结构基础

Montemayor, Eric J; Katolik, Adam; Clark, Nathaniel E; Taylor, Alexander B; Schuermann, Jonathan P; Combs, D Joshua; Johnsson, Richard; Holloway, Stephen P; Stevens, Scott W; Damha, Masad J; Hart, P John

Multiple polymer architectures of human polyhomeotic homolog 3 sterile alpha motif

人类多聚同源物3无菌α基序的多种聚合物结构

Nanyes, David R; Junco, Sarah E; Taylor, Alexander B; Robinson, Angela K; Patterson, Nicolle L; Shivarajpur, Ambika; Halloran, Jonathan; Hale, Seth M; Kaur, Yogeet; Hart, P John; Kim, Chongwoo A

A manganese-rich environment supports superoxide dismutase activity in a Lyme disease pathogen, Borrelia burgdorferi

富含锰的环境有利于莱姆病病原体伯氏疏螺旋体中超氧化物歧化酶的活性。

Aguirre, J Dafhne; Clark, Hillary M; McIlvin, Matthew; Vazquez, Christine; Palmere, Shaina L; Grab, Dennis J; Seshu, J; Hart, P John; Saito, Mak; Culotta, Valeria C