日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single-cell insights into tumor microenvironment heterogeneity and plasticity: transforming precision therapy in gastrointestinal cancers

单细胞视角揭示肿瘤微环境异质性和可塑性:革新胃肠道癌症的精准治疗

Weng, Jialei; Ju, Feng; Lyu, Zicheng; Fan, Ningbo; Smit, Daniel J; Xu, Wenxin; Wu, Xiaolin; Becker, Philip; Xu, Yinan; Schweiger, Michal R; Hillmer, Axel M; Harwig, Ralf; Gul, Sheraz; Link, Alexander; Meder, Lydia; Fang, Nan; Dong, Qiongzhu; Bruns, Christiane J; Ren, Ning; Zhao, Yue

HIV co-opts a cellular antiviral mechanism, activation of stress kinase PKR by its RNA, to enable splicing of rev/tat mRNA

HIV 利用其 RNA 激活应激激酶 PKR,从而劫持细胞抗病毒机制,以促进 rev/tat mRNA 的剪接。

Namer, Lise Sarah; Harwig, Alex; Heynen, Stephan P; Das, Atze T; Berkhout, Ben; Kaempfer, Raymond

The variable domain from dynamin-related protein 1 promotes liquid-liquid phase separation that enhances its interaction with cardiolipin-containing membranes

动力蛋白相关蛋白1的可变结构域促进液-液相分离,从而增强其与含心磷脂膜的相互作用。

Posey, Ammon E; Ross, Kyle A; Bagheri, Mehran; Lanum, Elizabeth N; Khan, Misha A; Jennings, Christine E; Harwig, Megan C; Kennedy, Nolan W; Hilser, Vincent J; Harden, James L; Hill, R Blake

Human Fis1 directly interacts with Drp1 in an evolutionarily conserved manner to promote mitochondrial fission

人类Fis1以进化上保守的方式与Drp1直接相互作用,促进线粒体分裂。

Nolden, Kelsey A; Harwig, Megan C; Hill, R Blake

Structural studies of human fission protein FIS1 reveal a dynamic region important for GTPase DRP1 recruitment and mitochondrial fission

人类裂变蛋白FIS1的结构研究揭示了一个对GTP酶DRP1募集和线粒体裂变至关重要的动态区域

Egner, John M; Nolden, Kelsey A; Harwig, Megan Cleland; Bonate, Ryan P; De Anda, Jaime; Tessmer, Maxx H; Noey, Elizabeth L; Ihenacho, Ugochukwu K; Liu, Ziwen; Peterson, Francis C; Wong, Gerard C L; Widlansky, Michael E; Hill, R Blake

Novel DNM1L variants impair mitochondrial dynamics through divergent mechanisms

新的 DNM1L 变体通过不同的机制损害线粒体动力学

Kelsey A Nolden, John M Egner, Jack J Collier, Oliver M Russell, Charlotte L Alston, Megan C Harwig, Michael E Widlansky, Souphatta Sasorith, Inês A Barbosa, Andrew Gl Douglas, Julia Baptista, Mark Walker, Deirdre E Donnelly, Andrew A Morris, Hui Jeen Tan, Manju A Kurian, Kathleen Gorman, Santosh Mo

Histone H3 and H4 tails play an important role in nucleosome phase separation

组蛋白H3和H4的尾部在核小体相分离中起着重要作用。

Hammonds, Erin F; Harwig, Megan Cleland; Paintsil, Emeleeta A; Tillison, Emma A; Hill, R Blake; Morrison, Emma A

Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression

靶向线粒体复合物 I 抑制剂对肿瘤细胞和免疫细胞的同步作用可抑制黑色素瘤进展。

Mahmoud AbuEid ,Donna M McAllister ,Laura McOlash ,Megan Cleland Harwig ,Gang Cheng ,Donovan Drouillard ,Kathleen A Boyle ,Micael Hardy ,Jacek Zielonka ,Bryon D Johnson ,R Blake Hill ,Balaraman Kalyanaraman ,Michael B Dwinell

Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells

新型 SHIP1 磷酸酶激活剂对恶性 B 细胞中 PI3K 信号传导的抑制作用的临床前评估

Elizabeth A Lemm #, Beatriz Valle-Argos #, Lindsay D Smith, Johanna Richter, Yohannes Gebreselassie, Matthew J Carter, Jana Karolova, Michael Svaton, Karel Helman, Nicola J Weston-Bell, Laura Karydis, Chris T Williamson, Georg Lenz, Jeremy Pettigrew, Curtis Harwig, Freda K Stevenson, Mark Cragg, Fra

Development of a Diet Quality Questionnaire for Improved Measurement of Dietary Diversity and Other Diet Quality Indicators (P13-018-19)

开发膳食质量问卷以改进膳食多样性和其他膳食质量指标的测量(P13-018-19)

Farber, J; Harwig, J; Carter, A; Abramczyk, Rachel; Sadiq, Sanah; Vaz, Cherie Lisa; Buso, Marion; Novita, Naomi; Boshuizen, Hendriek; Harrold, Jo; Raben, Anne; Halford, Jason; De Vries, Jeanne; Feskens, Edith; Brouwer-Brolsma, Elske; Herforth, Anna; Martínez-Steele, Euridice; Calixto, Giovanna; Sattamini, Isabela; Olarte, Deborah; Ballard, Terri; Monteiro, Carlos