日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Engineered IgG1-Fc--one fragment to bind them all

工程化IgG1-Fc——一个片段即可结合所有分子

Lobner, Elisabeth; Traxlmayr, Michael W; Obinger, Christian; Hasenhindl, Christoph

Construction of pH-sensitive Her2-binding IgG1-Fc by directed evolution

通过定向进化构建pH敏感的Her2结合IgG1-Fc

Michael W Traxlmayr, Elisabeth Lobner, Christoph Hasenhindl, Gerhard Stadlmayr, Chris Oostenbrink, Florian Rüker, Christian Obinger

Creating stable stem regions for loop elongation in Fcabs - insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations.

在 Fcabs 中创建稳定的茎区以促进环的延伸——结合酵母表面展示、计算机环重建和分子动力学模拟的见解

Hasenhindl Christoph, Lai Balder, Delgado Javier, Traxlmayr Michael W, Stadlmayr Gerhard, Rüker Florian, Serrano Luis, Oostenbrink Chris, Obinger Christian

Stability assessment on a library scale: a rapid method for the evaluation of the commutability and insertion of residues in C-terminal loops of the CH3 domains of IgG1-Fc

文库规模的稳定性评估:一种快速评估IgG1-Fc CH3结构域C端环中残基可互换性和插入性的方法

Hasenhindl, Christoph; Traxlmayr, Michael W; Wozniak-Knopp, Gordana; Jones, Phil C; Stadlmayr, Gerhard; Rüker, Florian; Obinger, Christian

Directed evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeast

通过对酵母展示的文库施加强热冲击来定向进化稳定的 IgG1-Fc 支架

Michael W Traxlmayr, Maximilian Faissner, Gerhard Stadlmayr, Christoph Hasenhindl, Bernhard Antes, Florian Rüker, Christian Obinger