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Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHD

在小鼠移植物抗宿主病（GVHD）期间，宿主白细胞介素 6 的产生调节脑内的炎症，但不调节色氨酸代谢。

doi:10.1172/jci.insight.93726

Belle, Ludovic; Zhou, Vivian; Stuhr, Kara L; Beatka, Margaret; Siebers, Emily M; Knight, Jennifer M; Lawlor, Michael W; Weaver, Casey; Hashizume, Misato; Hillard, Cecilia J; Drobyski, William R

Peripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response

在类风湿性关节炎患者中，托珠单抗治疗可显著增加外周血 CD4(+)CD25(+)CD127(low) 调节性 T 细胞的数量：调节性 T 细胞数量的增加与临床疗效相关。

期刊:Arthritis Research & Therapy

影响因子:4.6

doi:10.1186/s13075-015-0526-4

Kikuchi, Jun; Hashizume, Misato; Kaneko, Yuko; Yoshimoto, Keiko; Nishina, Naoshi; Takeuchi, Tsutomu

Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study)

基线血清骨桥蛋白水平可预测托珠单抗而非英夫利昔单抗在未接受生物制剂治疗的类风湿性关节炎患者中的临床疗效：一项为期 1 年的单中心前瞻性研究（庆应义塾大学 First-Bio 队列研究）

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0145468

Izumi, Keisuke; Kaneko, Yuko; Hashizume, Misato; Yoshimoto, Keiko; Takeuchi, Tsutomu

关节炎

发表日期：2015

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Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model

在胶原诱导性关节炎模型中，抗白细胞介素-6受体抗体通过减少骨髓中破骨细胞前体的数量来预防全身性骨量丢失。

期刊:Clinical and Experimental Immunology

影响因子:3.8

doi:10.1111/cei.12201

Tanaka, Keisuke; Hashizume, Misato; Mihara, Masahiko; Yoshida, Hiroto; Suzuki, Miho; Matsumoto, Yoshihiro

Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model.

在小鼠关节炎模型中，白细胞介素-6 通过降低 SLC19A1 的表达来调节甲氨蝶呤的抗关节炎作用

期刊:Arthritis Research & Therapy

影响因子:4.6

doi:10.1186/ar3821

Hashizume Misato, Yoshida Hiroto, Tanaka Keisuke, Suzuki Miho, Matsumoto Isao, Sumida Takayuki, Mihara Masahiko

Translating IL-6 biology into effective treatments

将IL-6生物学转化为有效的治疗方法

Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHD

在小鼠移植物抗宿主病（GVHD）期间，宿主白细胞介素 6 的产生调节脑内的炎症，但不调节色氨酸代谢。

Peripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response

在类风湿性关节炎患者中，托珠单抗治疗可显著增加外周血 CD4(+)CD25(+)CD127(low) 调节性 T 细胞的数量：调节性 T 细胞数量的增加与临床疗效相关。

Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study)

基线血清骨桥蛋白水平可预测托珠单抗而非英夫利昔单抗在未接受生物制剂治疗的类风湿性关节炎患者中的临床疗效：一项为期 1 年的单中心前瞻性研究（庆应义塾大学 First-Bio 队列研究）

Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model

在胶原诱导性关节炎模型中，抗白细胞介素-6受体抗体通过减少骨髓中破骨细胞前体的数量来预防全身性骨量丢失。

Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model.

在小鼠关节炎模型中，白细胞介素-6 通过降低 SLC19A1 的表达来调节甲氨蝶呤的抗关节炎作用