日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics

机器学习预测抗体聚集和粘度,用于蛋白质治疗剂的高浓度制剂开发

Pin-Kuang Lai, Austin Gallegos, Neil Mody, Hasige A Sathish, Bernhardt L Trout

Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity

脯氨酸、精氨酸、HCl 和 NaCl 与 IgG1 抗体的优先相互作用的分子计算及其对聚集和粘度的影响

Theresa K Cloutier, Chaitanya Sudrik, Neil Mody, Sathish A Hasige, Bernhardt L Trout

What makes the pregnant women revisit public hospitals for research? Participant engagement and retention trial in a public hospital (PERTH): an RCT protocol

是什么促使孕妇再次光顾公立医院参与研究?一项在珀斯公立医院开展的参与者参与度和保留率试验:一项随机对照试验方案

Babu, Giridhara R; Karthik, Maithili; Ravi, Deepa; Ana, Yamuna; Shriyan, Prafulla; Hasige, Kiran Kumar; Deshpande, Keerti; Siddlingaiah, Lokesh Bangalore; Kinra, Sanjay; Murthy, Gudlavalleti Venkata Satyanarayana

Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity

IgG1抗体中电荷介导的Fab-Fc相互作用可诱导可逆的自缔合、聚集和黏度升高。

Arora, Jayant; Hu, Yue; Esfandiary, Reza; Sathish, Hasige A; Bishop, Steven M; Joshi, Sangeeta B; Middaugh, C Russell; Volkin, David B; Weis, David D

Computational tool for the early screening of monoclonal antibodies for their viscosities

用于单克隆抗体粘度早期筛选的计算工具

Agrawal, Neeraj J; Helk, Bernhard; Kumar, Sandeep; Mody, Neil; Sathish, Hasige A; Samra, Hardeep S; Buck, Patrick M; Li, Li; Trout, Bernhardt L

Buffer-dependent fragmentation of a humanized full-length monoclonal antibody

缓冲液依赖性人源化全长单克隆抗体的片段化

Salinas, Branden A; Sathish, Hasige A; Shah, Ambarish U; Carpenter, John F; Randolph, Theodore W