日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Therapeutic antisense oligonucleotide mitigates retinal dysfunction in a pig model of CLN3 Batten disease

治疗性反义寡核苷酸可减轻CLN3巴顿病猪模型中的视网膜功能障碍

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf1141
Stratton, Matthew P; Centa, Jessica L; Swier, Vicki J; Pfeifer, Wanda L; Booth, Clarissa D; Albert, Karlee; Hunyara, John L; Rechtzigel, Mitchell J; Duelli, Fox J; Leppert, Hannah G; Rigo, Frank; Smit, Trisha; Jafar-Nejad, Paymaan; Weimer, Jill M; Drack, Arlene V; Hastings, Michelle L
发表日期：2025
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Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation

利用反义寡核苷酸调控NLRP3剪接以控制病理性炎症

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf1116
Klein, Roni; Onyuru, Janset; Centa, Jessica L; Viera, Estela M; Putnam, Christopher D; Hoffman, Hal M; Hastings, Michelle L
炎症
炎症/感染
信号转导
LRP3
NLRP3
发表日期：2025
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Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation.

利用反义寡核苷酸调节 NLRP3 剪接以控制病理性炎症

期刊:
影响因子:
doi:10.1101/2024.09.06.611206
Klein Roni, Onyuru Janset, Centa Jessica L, Viera Estela M, Duelli Fox J, Putnam Christopher D, Hoffman Hal M, Hastings Michelle L
炎症/感染
炎症
发表日期：2025
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Elevating microRNA levels by targeting biogenesis with steric-blocking antisense oligonucleotides

利用空间位阻反义寡核苷酸靶向生物合成来提高microRNA水平

期刊:RNA
影响因子:5
doi:10.1261/rna.080021.124
Havens, Mallory A; Hinrich, Anthony J; Rigo, Frank; Hastings, Michelle L
发表日期：2024
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Systematic deletion of symmetrical CFTR exons reveals new therapeutic targets for exon skipping antisense oligonucleotides

系统性删除对称性CFTR外显子揭示了外显子跳跃反义寡核苷酸的新治疗靶点

期刊:
影响因子:
doi:10.1093/narmme/ugae017
Pena-Rasgado, Cecilia; Rodriguez-Manriquez, Elvia; Dundr, Miroslav; Bridges, Robert J; Hastings, Michelle L; Michaels, Wren E
CFTR
发表日期：2024
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Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells

反义寡核苷酸介导的CFTR剪接校正可改善囊性纤维化患者来源支气管上皮细胞的氯离子分泌

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaa490
Michaels, Wren E; Bridges, Robert J; Hastings, Michelle L
上皮细胞
CFTR
细胞生物学
发表日期：2020
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Direct Delivery of Antisense Oligonucleotides to the Middle and Inner Ear Improves Hearing and Balance in Usher Mice

将反义寡核苷酸直接递送至中耳和内耳可改善 Usher 小鼠的听力和平衡能力

期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2020.08.002
Lentz, Jennifer J; Pan, Bifeng; Ponnath, Abhilash; Tran, Christopher M; Nist-Lund, Carl; Galvin, Alice; Goldberg, Hannah; Robillard, Katelyn N; Jodelka, Francine M; Farris, Hamilton E; Huang, Jun; Chen, Tianwen; Zhu, Hong; Zhou, Wu; Rigo, Frank; Hastings, Michelle L; Géléoc, Gwenaëlle S G
发表日期：2020
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Fetal gene therapy and pharmacotherapy to treat congenital hearing loss and vestibular dysfunction

利用胎儿基因疗法和药物疗法治疗先天性听力损失和前庭功能障碍

期刊:Hearing Research
影响因子:2.5
doi:10.1016/j.heares.2020.107931
Hastings, Michelle L; Brigande, John V
发表日期：2020
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Antisense Oligonucleotides for the Treatment of Inner Ear Dysfunction

反义寡核苷酸治疗内耳功能障碍

期刊:Neurotherapeutics
影响因子:6.9
doi:10.1007/s13311-019-00729-0
Hastings, Michelle L; Jones, Timothy A
发表日期：2019
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Searching for novel biomarkers using a mouse model of CLN3-Batten disease

利用CLN3-巴顿病小鼠模型寻找新型生物标志物

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0201470
Timm, Derek; Cain, Jacob T; Geraets, Ryan D; White, Katherine A; Koh, Seung Yon; Kielian, Tammy; Pearce, David A; Hastings, Michelle L; Weimer, Jill M
发表日期：2018
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