Haupt Axel相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Long-acting GIPR agonist LY3537021 reduces body weight and fasting blood glucose in patients with T2D: Preclinical development and phase 1 randomized ascending dose studies

长效GIPR激动剂LY3537021可降低2型糖尿病患者的体重和空腹血糖：临床前开发和1期随机递增剂量研究

期刊:Molecular Metabolism

影响因子:6.6

doi:10.1016/j.molmet.2025.102298

Roell, William; Alsina-Fernandez, Jorge; Qu, Hongchang; Coskun, Tamer; Benson, Charles; Haupt, Axel; Kelly, Ronan P; O'Farrell, Libbey; Sloop, Kyle W; Steele, James P; Ficorilli, James; Regmi, Ajit; Rettiganti, Mallikarjuna; Urva, Shweta; Mather, Kieren J; Pratt, Edward

发表日期：2026

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Eloralintide, a selective, long-acting amylin receptor agonist for treatment of obesity: Phase 1 proof of concept

埃洛拉林肽，一种选择性长效胰淀素受体激动剂，用于治疗肥胖症：I期概念验证

期刊:Diabetes Obesity & Metabolism

影响因子:5.7

doi:10.1111/dom.70439

Bhattachar, Shobha; Tham, Lai San; Tidemann-Miller, Beth; Ibriga, Hilda; Qu, Hongchang; Briere, Daniel A; Haupt, Axel; Mather, Kieren J; Pratt, Edward

发表日期：2026

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Oral Muvalaplin for Lowering of Lipoprotein(a): A Randomized Clinical Trial

口服Muvalaplin降低脂蛋白(a)：一项随机临床试验

期刊:Journal of the American Medical Association

影响因子:55

doi:10.1001/jama.2024.24017

Nicholls, Stephen J; Ni, Wei; Rhodes, Grace M; Nissen, Steven E; Navar, Ann Marie; Michael, Laura F; Haupt, Axel; Krege, John H

发表日期：2025

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Tirzepatide on ingestive behavior in adults with overweight or obesity: a randomized 6-week phase 1 trial

替拉帕肽对超重或肥胖成年人摄食行为的影响：一项为期 6 周的随机 1 期试验

期刊:Nature Medicine

影响因子:50

doi:10.1038/s41591-025-03774-9

Martin, Corby K; Carmichael, Owen T; Carnell, Susan; Considine, Robert V; Kareken, David A; Dydak, Ulrike; Mattes, Richard D; Scott, David; Shcherbinin, Sergey; Nishiyama, Hiroshi; Knights, Alastair; Urva, Shweta; Biernat, Lukasz; Pratt, Edward; Haupt, Axel; Mintun, Mark; Otero Svaldi, Diana; Milicevic, Zvonko; Coskun, Tamer

发表日期：2025

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Consistent improvements in liver histology across subgroups in a post hoc analysis of the SYNERGY-NASH trial with tirzepatide

SYNERGY-NASH试验的事后分析显示，替拉帕肽治疗各亚组的肝脏组织学均持续改善。

期刊:Jhep Reports

影响因子:7.5

doi:10.1016/j.jhepr.2025.101472

Hartman, Mark L; Loomba, Rohit; Lawitz, Eric J; Vuppalanchi, Raj; Boursier, Jérôme; Bugianesi, Elisabetta; Yoneda, Masato; Tang, Yuanyuan; Brouwers, Bram; Bunck, Mathijs C; Haupt, Axel; Sanyal, Arun J

发表日期：2025

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Eloralintide (LY3841136), a novel amylin receptor agonist for the treatment of obesity: From discovery to clinical proof of concept

埃洛拉林肽（LY3841136），一种用于治疗肥胖症的新型胰淀素受体激动剂：从发现到临床概念验证

期刊:Molecular Metabolism

影响因子:6.6

doi:10.1016/j.molmet.2025.102271

Briere, Daniel A; Qu, Hongchang; Lansu, Katherine; He, Minxia Michelle; Moyers, Julie S; Coskun, Tamer; Long, Annie; Allen, Dawn; O'Farrell, Libbey; Bowen, Breanna; Pratt, Edward; Tidemann-Miller, Beth; Tham, Lai San; Ibriga, Hilda; Alsina-Fernandez, Jorge; Mather, Kieren J; Haupt, Axel; Bhattachar, Shobha N

发表日期：2025

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Decreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids

瑞他曲肽治疗后循环 ANGPTL3/8 浓度的降低与血脂的降低平行。

期刊:Diabetes Obesity & Metabolism

影响因子:5.7

doi:10.1111/dom.16661

Wen, Yi; Lemen, Deven; Lin, Yanzhu; Chen, Yan Q; Regmi, Ajit; Roell, William C; Thomas, Melissa K; Hartman, Mark L; Coskun, Tamer; Milicevic, Zvonko; Haupt, Axel; Ruotolo, Giacomo; Konrad, Robert J

发表日期：2025

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Impact of tirzepatide treatment on participant-reported food craving and food preference: Secondary analyses of a phase 1 randomised controlled trial in people with obesity with dietary restriction

替泽帕肽治疗对参与者报告的食物渴望和食物偏好的影响：一项针对饮食限制肥胖患者的 1 期随机对照试验的二次分析

期刊:Diabetes Obesity & Metabolism

影响因子:5.7

doi:10.1111/dom.70063

Kennedy, Sam F; Knights, Alastair; Ravussin, Eric; Sanchez-Delgado, Guillermo; Nishiyama, Hiroshi; Qian, Hui-Rong; Pratt, Edward J; Milicevic, Zvonko; Haupt, Axel; Coskun, Tamer; Martin, Corby K

发表日期：2025

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The Effect of Retatrutide on Kidney Parameters in Participants With Type 2 Diabetes Mellitus and/or Obesity

瑞他曲肽对2型糖尿病和/或肥胖患者肾脏参数的影响

期刊:Kidney International Reports

影响因子:5.7

doi:10.1016/j.ekir.2025.03.049

Heerspink, Hiddo J L; Lu, Zeqing; Du, Yu; Duffin, Kevin L; Coskun, Tamer; Haupt, Axel; Hartman, Mark L

发表日期：2025

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Counterregulatory response to hypoglycemia during a hypoglycemic clamp in people with type 2 diabetes treated with tirzepatide

在接受替拉帕肽治疗的 2 型糖尿病患者中，低血糖钳夹试验期间的低血糖反调节反应

期刊:Frontiers in Endocrinology

影响因子:4.6

doi:10.3389/fendo.2025.1627947

Pieber, Thomas R; Svehlikova, Eva; Urva, Shweta; Haupt, Axel; Zhou, Chunmei; Coskun, Tamer; Höller, Vera; Fluhr, Gabriele; Karanikas, Chrisanthi A; Milicevic, Zvonko; Pratt, Edward John

发表日期：2025

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