Havener相关文献与解析，生知库 | 链接生命科学的每一步

Dupont, Robert L; Xu, Yang; Borbora, Angana; Wang, Xinyu; Azadi, Fatemeh; Havener, Kaden; Lewis, Broderick; Deng, Weichen; Tan, Benjamin W; Li, Shucong; Zhang, Rui; Yao, Yuxing; Manna, Uttam; Wang, Xiaoguang

发表日期：2025

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Development of a Second-Generation, In Vivo Chemical Probe for PIKfyve

PIKfyve 第二代体内化学探针的开发

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.4c02531

Sophia M Min, Frances M Bashore, Jeffery L Smith, Tammy M Havener, Stefanie Howell, Haoxi Li, Rafael M Couñago, Konstantin I Popov, Alison D Axtman

发表日期：2025

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More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication

不仅仅是酰胺生物电子等排体：发现含 1,2,4-三唑的吡唑并[1,5- a]嘧啶宿主 CSNK2 抑制剂用于对抗 β-冠状病毒复制

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.4c00962

Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael M Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David H Drewry, Timothy M Willson

Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2

通过战略性氟化获得强效、选择性、代谢稳定且口服生物可利用的 CSNK2 抑制剂

期刊:Molecules

影响因子:4.2

doi:10.3390/molecules29174158

Han Wee Ong, Xuan Yang, Jeffery L Smith, Sharon Taft-Benz, Stefanie Howell, Rebekah J Dickmander, Tammy M Havener, Marcia K Sanders, Jason W Brown, Rafael M Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David H Drewry, Timothy M Willson

代谢

发表日期：2024

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Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer

鉴定用于治疗 CLN1 巴顿病和癌症的棕榈酰蛋白硫酯酶 1 的新调节剂和抑制剂

期刊:ACS Omega

影响因子:3.7

doi:10.1021/acsomega.3c09607

Ana C Puhl, Renuka Raman, Tammy M Havener, Eni Minerali, Anthony J Hickey, Sean Ekins

肿瘤

发表日期：2024

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Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore

发现具有 II 型抑制剂药效团的强效恶性疟原虫蛋白激酶 6 (PfPK6) 抑制剂

期刊:European Journal of Medicinal Chemistry

影响因子:6

doi:10.1016/j.ejmech.2022.115043

Han Wee Ong, Anna Truong, Frank Kwarcinski, Chandi de Silva, Krisha Avalani, Tammy M Havener, Michael Chirgwin, Kareem A Galal, Caleb Willis, Andreas Krämer, Shubin Liu, Stefan Knapp, Emily R Derbyshire, Reena Zutshi, David H Drewry

信号转导

发表日期：2023

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Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy

药物基因组学分析表明 B 细胞发育状态和 MKL1 是抗 CD20 单克隆抗体治疗敏感性的决定因素

期刊:Cells

影响因子:5.1

doi:10.3390/cells12121574

George W Small, Farida S Akhtari, Adrian J Green, Tammy M Havener, Michael Sikes, Julia Quintanhila, Ricardo D Gonzalez, David M Reif, Alison A Motsinger-Reif, Howard L McLeod, Tim Wiltshire

RYK Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients

RYK 基因表达与胶质瘤患者替莫唑胺药物反应变化及临床结果相关

期刊:Pharmaceuticals

影响因子:

doi:10.3390/ph16050726

Ricardo D Gonzalez, George W Small, Adrian J Green, Farida S Akhtari, Tammy M Havener, Julia C F Quintanilha, Amber B Cipriani, David M Reif, Howard L McLeod, Alison A Motsinger-Reif, Tim Wiltshire

Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization

多组学分析表明，共济失调蛋白 sacsin 是整合素运输和突触组织所必需的

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2022.111580

Lisa E L Romano, Wen Yih Aw, Kathryn M Hixson, Tatiana V Novoselova, Tammy M Havener, Stefanie Howell, Bonnie Taylor-Blake, Charlotte L Hall, Lei Xing, Josh Beri, Suran Nethisinghe, Laura Perna, Abubakar Hatimy, Ginevra Chioccioli Altadonna, Lee M Graves, Laura E Herring, Anthony J Hickey, Konstanti

信号转导

发表日期：2022

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Multiple approaches to repurposing drugs for neuroblastoma

重新利用药物治疗神经母细胞瘤的多种方法

期刊:Bioorganic & Medicinal Chemistry

影响因子:3.3

doi:10.1016/j.bmc.2022.117043

Laura Rank, Ana C Puhl, Tammy M Havener, Edward Anderson, Daniel H Foil, Kimberley M Zorn, Natalia Monakhova, Olga Riabova, Anthony J Hickey, Vadim Makarov, Sean Ekins

Synergistic Adhesion and Shape Deformation in Nanowire-Structured Liquid Crystal Elastomers

纳米线结构液晶弹性体中的协同粘附和形状变形

Development of a Second-Generation, In Vivo Chemical Probe for PIKfyve

PIKfyve 第二代体内化学探针的开发

More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication

不仅仅是酰胺生物电子等排体：发现含 1,2,4-三唑的吡唑并[1,5- a]嘧啶宿主 CSNK2 抑制剂用于对抗 β-冠状病毒复制

Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2

通过战略性氟化获得强效、选择性、代谢稳定且口服生物可利用的 CSNK2 抑制剂

Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer

鉴定用于治疗 CLN1 巴顿病和癌症的棕榈酰蛋白硫酯酶 1 的新调节剂和抑制剂

Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore

发现具有 II 型抑制剂药效团的强效恶性疟原虫蛋白激酶 6 (PfPK6) 抑制剂

Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy

药物基因组学分析表明 B 细胞发育状态和 MKL1 是抗 CD20 单克隆抗体治疗敏感性的决定因素

RYK Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients

RYK 基因表达与胶质瘤患者替莫唑胺药物反应变化及临床结果相关

Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization

多组学分析表明，共济失调蛋白 sacsin 是整合素运输和突触组织所必需的

Multiple approaches to repurposing drugs for neuroblastoma

重新利用药物治疗神经母细胞瘤的多种方法