A shared DNA-repeat toxicity threshold, reached somatically at cell-type-specific rates, unites cortical and striatal neurodegeneration in Huntington's disease
亨廷顿病中皮质和纹状体神经退行性变均由共同的DNA重复序列毒性阈值引起,该阈值在体细胞中以细胞类型特异性速率达到。
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影响因子:
doi:10.64898/2025.12.09.688862
Kashin, Seva; Lee, Won-Seok; McDonald, Tara M; Morris, Kiely; Handsaker, Robert E; Mello, Curtis; Spina, Liv; Reed, Nora M; de Rivera, Heather; Jana, Sri Havya; Hogan, Marina; Berretta, Sabina; McCarroll, Steven A