日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Direct AMPK Activation Confers Mutation-Independent Therapeutic Benefit in Duchenne Muscular Dystrophy

直接激活 AMPK 可赋予杜氏肌营养不良症与突变无关的治疗益处

Ng, Sean Y; Mikhail, Andrew I; Mattina, Stephanie R; Lesinski, Magda A; Rebalka, Irena A; Hamstra, Sophie I; Xhuti, Donald; Fajardo, Val A; Tarnopolsky, Mark A; Nederveen, Joshua P; Steinberg, Gregory R; Hawke, Thomas J; Ljubicic, Vladimir

Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy.

自主运动可引起杜氏肌营养不良症严重 D2.mdx 小鼠模型的生理和分子水平改善。

Mattina Stephanie R, Ng Sean Y, Mikhail Andrew I, Stouth Derek W, Jornacion Cora E, Rebalka Irena A, Hawke Thomas J, Ljubicic Vladimir

Lipophilic but not hydrophilic statin therapy improves cardiodynamics without affecting skeletal muscle morphology or function in geriatric Wistar rats

亲脂性而非亲水性他汀类药物治疗可改善老年Wistar大鼠的心脏动力学,且不影响骨骼肌的形态或功能。

Rebalka, Irena A; Alshamali, Razan; vanLieshout, Tiffany L; Gingrich, Molly A; Marlatt, Matthew R; Ljubicic, Vladimir; Simpson, Jeremy A; Hawke, Thomas J

Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus.

2 型糖尿病男性患者骨骼肌肌球蛋白超松弛和能量代谢失调

Lewis Christopher T A, Moreno-Justicia Roger, Savoure Lola, Calvo Enrique, Bak Agata, Laitila Jenni, Seaborne Robert A E, Larsen Steen, Iwamoto Hiroyuki, Cefis Marina, Morais Jose A, Gouspillou Gilles, Alegre-Cebollada Jorge, Hawke Thomas J, Vazquez Jesús, Adrover Miquel, Marcangeli Vincent, Hammad Rami, Granet Jordan, Gaudreau Pierrette, Aubertin-Leheudre Mylène, Bélanger Marc, Robitaille Richard, Deshmukh Atul S, Ochala Julien

Mitohormesis during advanced stages of Duchenne muscular dystrophy reveals a redox-sensitive creatine pathway that can be enhanced by the mitochondrial-targeting peptide SBT-20

杜氏肌营养不良症晚期线粒体兴奋效应揭示了一种氧化还原敏感的肌酸通路,该通路可被线粒体靶向肽SBT-20增强。

Hughes, Meghan C; Ramos, Sofhia V; Brahmbhatt, Aditya N; Turnbull, Patrick C; Polidovitch, Nazari N; Garibotti, Madison C; Schlattner, Uwe; Hawke, Thomas J; Simpson, Jeremy A; Backx, Peter H; Perry, Christopher Gr

Muscle mitochondrial function is impaired in adults with type 1 diabetes

1型糖尿病成人患者的肌肉线粒体功能受损

Gottlieb, Daniel; Abushamat, Layla A; Nadeau, Kristen J; Regensteiner, Judith G; Reusch, Jane E B; Tommerdahl, Kalie L; Rice, John; Knaub, Leslie A; Monaco, Cynthia M F; Hawke, Thomas J; Perry, Christopher G R; Cree, Melanie G; Schauer, Irene E

Targeting skeletal muscle health with exercise in people with type 1 diabetes: A protocol for HOMET1D, a prospective observational trial with matched controls

通过运动改善1型糖尿病患者的骨骼肌健康:HOMET1D方案,一项前瞻性观察性试验,设有匹配对照组

Rebalka, Irena A; Noguchi, Kenneth S; Bulyovsky, Kayla R; Badour, Matthew I; Juracic, Emma S; Barrett, Khandra; Brahmbhatt, Aditya; Al-Khazraji, Baraa; Punthakee, Zubin; Perry, Christopher G R; Kumbhare, Dinesh A; MacDonald, Maureen J; Hawke, Thomas J

Whole body resistance training on functional outcomes of patients with Stage 4 or 5 chronic kidney disease: A systematic review

全身阻力训练对4期或5期慢性肾脏病患者功能结局的影响:系统评价

Abrahim, Salma; Steele, Alexandra P; Voth, Jennifer; Krepinsky, Joan C; Lanktree, Matthew B; Hawke, Thomas J

Diabetic Bone Disease and Diabetic Myopathy: Manifestations of the Impaired Muscle-Bone Unit in Type 1 Diabetes

糖尿病骨病和糖尿病肌病:1型糖尿病肌骨单元受损的表现

Travis, Callie; Srivastava, Priya S; Hawke, Thomas J; Kalaitzoglou, Evangelia

Statin administration activates system xC(-) in skeletal muscle: a potential mechanism explaining statin-induced muscle pain

他汀类药物激活骨骼肌中的xC(-)系统:一种解释他汀类药物诱发肌肉疼痛的潜在机制

Rebalka, Irena A; Cao, Andrew W; May, Linda L; Tarnopolsky, Mark A; Hawke, Thomas J