日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types.

CDS1 和 CDS2 之间的合成致死相互作用是葡萄膜黑色素瘤以及多种肿瘤类型的弱点

Chan Pui Ying, Alexander Diana, Mehta Ishan, Matsuyama Larissa Satiko Alcantara Sekimoto, Harle Victoria, Olvera-León Rebeca, Park Jun Sung, Arriaga-González Fernanda G, van der Weyden Louise, Cheema Saamin, Iyer Vivek, Offord Victoria, Barneda David, Hawkins Phillip T, Stephens Len, Kozik Zuza, Woods Michael, Wong Kim, Balmus Gabriel, Vinceti Alessandro, Thompson Nicola A, Del Castillo Velasco-Herrera Martin, Wessels Lodewyk, van de Haar Joris, Gonçalves Emanuel, Sinha Sanju, Vázquez-Cruz Martha Estefania, Bisceglia Luisa, Raimondi Francesco, Choudhary Jyoti, Patiyal Sumeet, Venkatesh Anjan, Iorio Francesco, Ryan Colm J, Adams David J

Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses

前沿科学:TNF-α 和 GM-CSF1 的启动增强了 SOS1/2 在驱动 Ras、PI3K-γ 和中性粒细胞促炎反应激活中的作用

Suire, Sabine; Baltanas, Fernando C; Segonds-Pichon, Anne; Davidson, Keith; Santos, Eugenio; Hawkins, Phillip T; Stephens, Len R

Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy

CSF1R+巨噬细胞和Foxp3+调节性T细胞之间的补偿作用驱动肿瘤免疫治疗耐药性

Gyori, David; Lim, Ee Lyn; Grant, Francis M; Spensberger, Dominik; Roychoudhuri, Rahul; Shuttleworth, Stephen J; Okkenhaug, Klaus; Stephens, Len R; Hawkins, Phillip T

Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

功能性药物筛选揭示抗惊厥药可通过肌醇耗竭增强不依赖于mTOR的自噬途径杀灭结核分枝杆菌

Schiebler, Mark; Brown, Karen; Hegyi, Krisztina; Newton, Sandra M; Renna, Maurizio; Hepburn, Lucy; Klapholz, Catherine; Coulter, Sarah; Obregón-Henao, Andres; Henao Tamayo, Marcela; Basaraba, Randall; Kampmann, Beate; Henry, Katherine M; Burgon, Joseph; Renshaw, Stephen A; Fleming, Angeleen; Kay, Robert R; Anderson, Karen E; Hawkins, Phillip T; Ordway, Diane J; Rubinsztein, David C; Floto, Rodrigo Andres

Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3.

磷脂酰肌醇 3-OH 激酶通过其效应分子 ARAP3 发出信号,调节中性粒细胞中整合素依赖性过程

Gambardella Laure, Anderson Karen E, Jakus Zoltán, Kovács Miklós, Voigt Susann, Hawkins Phillip T, Stephens Len, Mócsai Attila, Vermeren Sonja

3D time series analysis of cell shape using Laplacian approaches

利用拉普拉斯方法对细胞形状进行三维时间序列分析

Du, Cheng-Jin; Hawkins, Phillip T; Stephens, Len R; Bretschneider, Till

PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils

在原代小鼠中性粒细胞中,PtdIns3P 和 Rac 指导 NADPH 氧化酶在 FcR 介导的吞噬作用过程中组装于一种新型的吞噬体前区室上。

Anderson, Karen E; Chessa, Tamara A M; Davidson, Keith; Henderson, Robert B; Walker, Simon; Tolmachova, Tanya; Grys, Katarzyna; Rausch, Oliver; Seabra, Miguel C; Tybulewicz, Victor L J; Stephens, Len R; Hawkins, Phillip T

Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing.

p40phox-/- 小鼠的中性粒细胞在 NADPH 氧化酶调节和氧化剂依赖性细菌杀灭方面表现出严重的缺陷

Ellson Chris D, Davidson Keith, Ferguson G John, O'Connor Rod, Stephens Len R, Hawkins Phillip T

PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation

PtdIns3P与p40phox的PX结构域结合是NADPH氧化酶激活过程中的一种生理信号。

Ellson, Chris; Davidson, Keith; Anderson, Karen; Stephens, Len R; Hawkins, Phillip T