Hay Michael P相关文献与解析，生知库 | 链接生命科学的每一步

Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity

替拉帕明还原的亚细胞定位显著影响有氧细胞毒性，但不影响缺氧细胞毒性

Guise, Chris P; Abbattista, Maria R; Anderson, Robert F; Li, Dan; Taghipouran, Rana; Tsai, Angela; Lee, Su Jung; Smaill, Jeff B; Denny, William A; Hay, Michael P; Wilson, William R; Hicks, Kevin O; Patterson, Adam V

毒理研究

细胞生物学

发表日期：2020

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Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck Cancer

患者来源的异种移植和类器官模型用于精准治疗头颈癌肿瘤微环境

期刊:Cancers

影响因子:4.4

doi:10.3390/cancers12123743

Lee, Tet Woo; Lai, Amy; Harms, Julia K; Singleton, Dean C; Dickson, Benjamin D; Macann, Andrew M J; Hay, Michael P; Jamieson, Stephen M F

Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice

还原代谢影响缺氧靶向苯并三嗪二氧化物抗癌药物SN30000在小鼠体内的毒性和药代动力学

期刊:Frontiers in Pharmacology

影响因子:4.8

doi:10.3389/fphar.2017.00531

Gu, Yongchuan; Chang, Tony T-A; Wang, Jingli; Jaiswal, Jagdish K; Edwards, David; Downes, Noel J; Liyanage, H D Sarath; Lynch, Courtney R H; Pruijn, Frederik B; Hickey, Anthony J R; Hay, Michael P; Wilson, William R; Hicks, Kevin O

18F-EF5 PET imaging as an early response biomarker for the hypoxia-activated prodrug SN30000 combined with radiation treatment in a non-small cell lung cancer xenograft model

在非小细胞肺癌异种移植模型中，18F-EF5 PET成像作为缺氧激活前药SN30000联合放射治疗的早期反应生物标志物

期刊:

影响因子:

doi:10.2967/jnumed.112.116293

Chitneni, Satish K; Bida, Gerald T; Yuan, Hong; Palmer, Gregory M; Hay, Michael P; Melcher, Thorsten; Wilson, William R; Zalutsky, Michael R; Dewhirst, Mark W

SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells

对选择性诱导von Hippel-Lindau缺陷型肾细胞癌细胞自噬性细胞死亡的4-吡啶基杂环苯胺类化合物进行构效关系研究

期刊:Bioorganic & Medicinal Chemistry

影响因子:3

doi:10.1016/j.bmc.2011.04.042

Bonnet, Muriel; Flanagan, Jack U; Chan, Denise A; Lai, Edwin W; Nguyen, Phuong; Giaccia, Amato J; Hay, Michael P

Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors

药代动力学/药效学模型确定 SN30000 和 SN29751 为替拉帕明类似物，具有更高的组织渗透性和对肿瘤缺氧细胞的杀伤作用。

期刊:Clinical Cancer Research

影响因子:10.2

doi:10.1158/1078-0432.CCR-10-1439

Hicks, Kevin O; Siim, Bronwyn G; Jaiswal, Jagdish K; Pruijn, Frederik B; Fraser, Annie M; Patel, Rita; Hogg, Alison; Liyanage, H D Sarath; Dorie, Mary Jo; Brown, J Martin; Denny, William A; Hay, Michael P; Wilson, William R

Novel Prodrug Strategies for the Treatment of Tuberculosis

治疗结核病的新型前药策略

Megakaryocyte maturation involves activation of the adaptive unfolded protein response.

巨核细胞成熟涉及适应性未折叠蛋白反应的激活

Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity

替拉帕明还原的亚细胞定位显著影响有氧细胞毒性，但不影响缺氧细胞毒性

Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck Cancer

患者来源的异种移植和类器官模型用于精准治疗头颈癌肿瘤微环境

Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice

还原代谢影响缺氧靶向苯并三嗪二氧化物抗癌药物SN30000在小鼠体内的毒性和药代动力学

18F-EF5 PET imaging as an early response biomarker for the hypoxia-activated prodrug SN30000 combined with radiation treatment in a non-small cell lung cancer xenograft model

在非小细胞肺癌异种移植模型中，18F-EF5 PET成像作为缺氧激活前药SN30000联合放射治疗的早期反应生物标志物

SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells

对选择性诱导von Hippel-Lindau缺陷型肾细胞癌细胞自噬性细胞死亡的4-吡啶基杂环苯胺类化合物进行构效关系研究

Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors

药代动力学/药效学模型确定 SN30000 和 SN29751 为替拉帕明类似物，具有更高的组织渗透性和对肿瘤缺氧细胞的杀伤作用。