日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GIPR signaling modulates PYY-induced hypophagia and malaise in rodents

GIPR信号通路调节啮齿动物中PYY诱导的食欲减退和不适感

Borner, Tito; Pataro, Allison M; Curtis, Genevieve R; Alonso, Brandon; Hu, Jiayin; Fortin, Samantha M; Koul-Tiwari, Richa; Hughes, Emily; Kong, Jimmy X; Jordan, Emily; Barnes, Robert; Bernardo, Barbara; Gardner, Maxwell; Ma, Wenzhe; Gosset, James R; Esquejo, Ryan M; Fortin, Jean-Philippe; De Jonghe, Bart C; Bence, Kendra K; Hayes, Matthew R

Survodutide acts through circumventricular organs in the brain and activates neuronal regions associated with appetite regulation.

舒沃度肽通过脑室周围器官发挥作用,激活与食欲调节相关的神经元区域。

Zimmermann Tina, Bleymehl Katherin, Haebel Peter, Perens Johanna, Roostalu Urmas, Hecksher-Sørensen Jacob, Doerr Jonas, Jarosch Sebastian, Lam Daniel, Klein Holger, Pekcec Anton, Chehimi Samar N, Crist Richard C, Reiner Benjamin C, Hayes Matthew R, Augustin Robert

The estrous cycle moderates the food and body weight suppressive effects of glucagon-like peptide-1 receptor agonism

动情周期调节胰高血糖素样肽-1受体激动剂对食物摄入和体重的抑制作用。

Applebey, Sarah V; Xiao, Allison G; Reiner, Benjamin C; Hayes, Matthew R

GLP-1R biased cAMP agonism maintains glycemic control with reduced malaise and emesis in preclinical mammalian models

在临床前哺乳动物模型中,GLP-1R 偏向性 cAMP 激动剂作用可维持血糖控制,并减少不适和呕吐。

Baumer-Harrison, Caitlin; Aldaghma, Danya; White, Alex D; Applebey, Sarah V; Pataro, Allison M; Mohiby, Allaha Z; Alonso, Brandon; Xiao, Allison G; O'Farrell, Libbey S; Qian, Yuewei; Coskun, Tamer; Coghlan, Matthew P; Willard, Francis S; Ai, Minrong; Sloop, Kyle W; Doyle, Robert P; Borner, Tito; De Jonghe, Bart C; Hayes, Matthew R

Therapeutic potential for glial-derived octadecaneuropeptide in the treatment of obesity

神经胶质细胞衍生十八肽在肥胖症治疗中的治疗潜力

Orativskyi, Oleksandr; Geisler, Caroline E; Hayes, Matthew R; Doyle, Robert P

Brain activity associated with breakthrough food preoccupation in an individual on tirzepatide

服用替拉帕肽的个体出现突破性食物偏好时,其大脑活动与此相关。

Choi, Wonkyung; Nho, Young-Hoon; Qiu, Liming; Chang, Andrew; Campos, Gustavo; Seilheimer, Robert L; Wilent, W Bryan; Bakalov, David; Firdous, Nida; Kerr, Marie; Joshi, Disha; Maze, Gabriella; Topalovic, Uros; Batista, Daniel; Suthana, Nanthia; Amaro, Anastassia; Hayes, Matthew R; Cajigas, Iahn; Cristancho, Mario; Allison, Kelly C; Pesaran, Bijan; Scangos, Katherine W; Gold, Joshua I; Wadden, Thomas A; Halpern, Casey H

Ventral hippocampus neurons encode meal-related memory.

腹侧海马神经元编码与进食相关的记忆

Décarie-Spain Léa, Gu Cindy, Tierno Lauer Logan, Subramanian Keshav S, Chehimi Samar N, Kao Alicia E, Gao Serena X, Deng Iris, Bashaw Alexander G, Klug Molly E, Rea Jessica J, Waldow Alice I, Galbokke Ashyah Hewage, Moody Olivia, Donohue Kristen N, Yang Mingxin, de Lartigue Guillaume, Myers Kevin P, Crist Richard C, Reiner Benjamin C, Hayes Matthew R, Kanoski Scott E

Hindbrain octadecaneuropeptide gliotransmission as a therapeutic target for energy balance control without nausea or emesis

后脑十八肽神经胶质传递作为能量平衡控制的治疗靶点,不引起恶心或呕吐

Geisler, Caroline E; Chichura, Kylie S; Orativskyi, Oleksandr; Hu, Jiayin; Belser, Drew L; Pelletier, Caitlyn M; Borner, Tito; Baumer-Harrison, Caitlin; De Jonghe, Bart C; Crist, Richard C; Reiner, Benjamin C; Doyle, Robert P; Hayes, Matthew R

Hypophagia and body weight loss by tirzepatide are accompanied by fewer GI adverse events compared to semaglutide in preclinical models.

在临床前模型中,与司美格鲁肽相比,替拉帕肽引起的食欲减退和体重减轻伴随的胃肠道不良事件较少

Borner Tito, Pataro Allison M, Doebley Sarah A, Furst Charles D, White Alex D, Gao Serena X, Chow Angela, Sanchez-Navarro Marcos J, Ghidewon Misgana Y, Halas Julia G, Mohiby Allaha Z, Willard Francis S, Grill Harvey J, Ai Minrong, Samms Ricardo J, Hayes Matthew R, De Jonghe Bart C

Characterizing Brainstem GLP-1 Control of Sensory-Specific Satiety in Male and Female Rats Across the Estrous Cycle.

表征雄性和雌性大鼠在动情周期中脑干 GLP-1 对感觉特异性饱腹感的控制

Applebey Sarah V, Xiao Allison G, Harris Erin P, Levine Caleb, Belser Drew L, Geisler Caroline E, Parent Marise B, Bangasser Debra A, Crist Richard C, Reiner Benjamin C, Hayes Matthew R