PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein
神经干细胞中PI3K的激活会驱动肿瘤发生,而靶向cAMP反应元件结合蛋白可以缓解这一过程。
期刊:Neuro-Oncology
影响因子:13.4
doi:10.1093/neuonc/noy068
Daniel, Paul M; Filiz, Gulay; Brown, Daniel V; Christie, Michael; Waring, Paul M; Zhang, Yi; Haynes, John M; Pouton, Colin; Flanagan, Dustin; Vincan, Elizabeth; Johns, Terrance G; Montgomery, Karen; Phillips, Wayne A; Mantamadiotis, Theo
干细胞
发育与干细胞
GPCR/Calcium/cAMP
肿瘤
细胞生物学
肿瘤免疫