日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Using genetic association data to guide drug discovery and development: Review of methods and applications

利用遗传关联数据指导药物发现和开发:方法和应用综述

Burgess, Stephen; Mason, Amy M; Grant, Andrew J; Slob, Eric A W; Gkatzionis, Apostolos; Zuber, Verena; Patel, Ashish; Tian, Haodong; Liu, Cunhao; Haynes, William G; Hovingh, G Kees; Knudsen, Lotte Bjerre; Whittaker, John C; Gill, Dipender

Leveraging human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide signalling

利用人类遗传数据研究葡萄糖依赖性促胰岛素多肽信号传导对心血管代谢的影响

Karhunen, Ville; Daghlas, Iyas; Zuber, Verena; Vujkovic, Marijana; Olsen, Anette K; Knudsen, Lotte Bjerre; Haynes, William G; Howson, Joanna M M; Gill, Dipender

SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle

SUMO特异性蛋白酶2介导瘦素诱导的骨骼肌脂肪酸氧化

Koo, Young Do; Lee, Ji Seon; Lee, Seung-Ah; Quaresma, Paula G F; Bhat, Ratan; Haynes, William G; Park, Young Joo; Kim, Young-Bum; Chung, Sung Soo; Park, Kyong Soo

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

利用反义寡核苷酸沉默Pnpla3基因可改善Pnpla3 I148M敲入小鼠的非酒精性脂肪性肝炎和纤维化。

Lindén, Daniel; Ahnmark, Andrea; Pingitore, Piero; Ciociola, Ester; Ahlstedt, Ingela; Andréasson, Anne-Christine; Sasidharan, Kavitha; Madeyski-Bengtson, Katja; Zurek, Magdalena; Mancina, Rosellina M; Lindblom, Anna; Bjursell, Mikael; Böttcher, Gerhard; Ståhlman, Marcus; Bohlooly-Y, Mohammad; Haynes, William G; Carlsson, Björn; Graham, Mark; Lee, Richard; Murray, Sue; Valenti, Luca; Bhanot, Sanjay; Åkerblad, Peter; Romeo, Stefano

Hemoglobin A1c and C-reactive protein are independently associated with blunted nocturnal blood pressure dipping in obesity-related prediabetes

糖化血红蛋白A1c和C反应蛋白与肥胖相关糖尿病前期患者夜间血压下降幅度减弱独立相关。

Lane-Cordova, Abbi D; Kalil, Graziela Z; Wagner, Christopher J; Sindler, Amy L; Fiedorowicz, Jess G; Ajibewa, Tiwaloluwa; Haynes, William G; Pierce, Gary L

Publisher Correction: Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

出版商更正:芯片上人胰岛和肝球体的功能耦合:构建新型人体外2型糖尿病模型

Bauer, Sophie; Wennberg Huldt, Charlotte; Kanebratt, Kajsa P; Durieux, Isabell; Gunne, Daniela; Andersson, Shalini; Ewart, Lorna; Haynes, William G; Maschmeyer, Ilka; Winter, Annika; Ämmälä, Carina; Marx, Uwe; Andersson, Tommy B

Higher augmentation index is associated with tension-type headache and migraine in middle-aged/older humans with obesity

较高的增强指数与肥胖的中老年人群的紧张型头痛和偏头痛相关。

Kalil, Graziela Z; Recober, Ana; Hoang-Tienor, Ann; Bridget Zimmerman, Miriam; Haynes, William G; Pierce, Gary L

Finger volume pulse waveforms facilitate reliable assessment of heart rate variability, but not blood pressure variability or baroreflex function

指尖脉搏波形可以可靠地评估心率变异性,但不能评估血压变异性或压力反射功能。

Linder, Jonathan R; Stauss, Harald M; Gindes, Holly; Pierce, Gary L; Von Bergen, Nicholas H; Haynes, William G; Fiedorowicz, Jess G

Effects of antipsychotic drugs on cardiovascular variability in participants with bipolar disorder

抗精神病药物对双相情感障碍患者心血管变异性的影响

Linder, Jonathan R; Sodhi, Simrit K; Haynes, William G; Fiedorowicz, Jess G

Sildenafil increases sympathetically mediated vascular tone in humans

西地那非可增加人类交感神经介导的血管张力

Dopp, John M; Agapitov, Alexei V; Sinkey, Christine A; Haynes, William G; Phillips, Bradley G