日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An Inhibitor of Death-Associated Protein Kinase 3 (DAPK3) Disrupts Hippo Signaling and Intestinal Epithelial Regeneration in Murine DSS-Induced Colitis

死亡相关蛋白激酶3 (DAPK3) 抑制剂可破坏小鼠DSS诱导的结肠炎中的Hippo信号通路和肠上皮再生

Chen, Huey-Miin; Carlson, David A; Haystead, Timothy A J; MacDonald, Justin A

Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome.

选择性靶向恶性疟原虫 Hsp90 可破坏 26S 蛋白酶体

Mansfield Christopher R, Quan Baiyi, Chirgwin Michael E, Eduful Benjamin, Hughes Philip F, Neveu Gaëlle, Sylvester Kayla, Ryan Daniel H, Kafsack Björn F C, Haystead Timothy A J, Leahy James W, Fitzgerald Michael C, Derbyshire Emily R

Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers

新型靶向热休克蛋白90的光动力疗法与PD-1/PD-L1阻断疗法相结合,可诱导强效的全身抗肿瘤疗效和对乳腺癌的远隔效应。

Kaneko, Kensuke; Acharya, Chaitanya R; Nagata, Hiroshi; Yang, Xiao; Hartman, Zachary Conrad; Hobeika, Amy; Hughes, Philip F; Haystead, Timothy A J; Morse, Michael A; Lyerly, Herbert Kim; Osada, Takuya

A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase.

白细胞介素-1受体相关激酶1/4(IRAK-1/4)的高选择性抑制剂阐明了IRAK-1/4和TAK1激酶不同的信号传导作用

Scarneo Scott A, Hughes Philip F, Yang Kelly W, Carlson David A, Gurbani Deepak, Westover Kenneth D, Haystead Timothy A J

TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases

TAK1:一种强效的肿瘤坏死因子抑制剂,用于治疗炎症性疾病

Totzke, Juliane; Scarneo, Scott A; Yang, Kelly W; Haystead, Timothy A J

Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer

Fasnall是一种选择性FASN抑制剂,在HER2(+)乳腺癌的MMTV-Neu模型中显示出强大的抗肿瘤活性。

Alwarawrah, Yazan; Hughes, Philip; Loiselle, David; Carlson, David A; Darr, David B; Jordan, Jamie L; Xiong, Jessie; Hunter, Lucas M; Dubois, Laura G; Thompson, J Will; Kulkarni, Manjusha M; Ratcliff, Annette N; Kwiek, Jesse J; Haystead, Timothy A J

An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target

一种可诱导型热休克蛋白70小分子抑制剂显示出抗登革病毒活性,证实了Hsp70是宿主抗病毒靶点。

Howe, Matthew K; Speer, Brittany L; Hughes, Philip F; Loiselle, David R; Vasudevan, Subhash; Haystead, Timothy A J

Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70

鉴定出一种对诱导型热休克蛋白70具有选择性的变构小分子抑制剂

Howe, Matthew K; Bodoor, Khaldon; Carlson, David A; Hughes, Philip F; Alwarawrah, Yazan; Loiselle, David R; Jaeger, Alex M; Darr, David B; Jordan, Jamie L; Hunter, Lucas M; Molzberger, Eileen T; Gobillot, Theodore A; Thiele, Dennis J; Brodsky, Jeffrey L; Spector, Neil L; Haystead, Timothy A J

Hsp90, an unlikely ally in the war on cancer

Hsp90,抗癌战争中意想不到的盟友

Barrott, Jared J; Haystead, Timothy A J

Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension

血管平滑肌细胞中的血管紧张素II 1A型受体不影响高血压患者的主动脉重塑。

Sparks, Matthew A; Parsons, Kelly K; Stegbauer, Johannes; Gurley, Susan B; Vivekanandan-Giri, Anuradha; Fortner, Christopher N; Snouwaert, Jay; Raasch, Eric W; Griffiths, Robert C; Haystead, Timothy A J; Le, Thu H; Pennathur, Subramaniam; Koller, Beverly; Coffman, Thomas M