日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Synthesis and Biological Evaluation of Imidazopyridine-Isatin Hybrids as Inhibitors of Leishmania major Growth

咪唑并吡啶-靛红杂合物作为利什曼原虫生长抑制剂的合成及生物学评价

期刊:Drug Design Development and Therapy
影响因子:5.1
doi:10.2147/DDDT.S570670
El Hassab, Mahmoud A; Eldehna, Wagdy M; Elsayed, Zainab M; Elbadawi, Mostafa M; Negmeldin, Ahmed T; Balaha, Marwa; Nasralla, Sherry N; Monir, Rehan; Ibrahim, Tamer M; Abe, Manabu; Tawfik, Haytham O; Bekhit, Adnan A; Hemeda, Loah R
发表日期：2026
文献求助 收藏

Discovery of potent bisindole-based pyrazolopyridine derivatives as topoisomerase inhibitors: DNA damage induction and synergistic antileukemic activity

发现强效的基于双吲哚的吡唑并吡啶衍生物作为拓扑异构酶抑制剂：DNA损伤诱导和协同抗白血病活性

期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2026.1745220
Eldehna, Wagdy M; Tawfik, Haytham O; Veselá, Denisa; Peřina, Miroslav; Negmeldin, Ahmed T; Elsayed, Zainab M; Majrashi, Taghreed A; Vojáčková, Veronika; Elbadawi, Mostafa M; Shaldam, Moataz A; Kryštof, Vladimír; Abdel-Aziz, Hatem A
白血病
毒理研究
发表日期：2026
文献求助 收藏

Pyrazole-triazole hybrids as kinase-triad inhibitors: a triple-target strategy for synergistic anticancer therapy

吡唑-三唑杂合物作为激酶三联体抑制剂：一种用于协同抗癌治疗的三靶点策略

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d6md00022c
Elkotamy, Mahmoud S; Elgohary, Mohamed K; Fakhry, Mariam M; Albakri, Mohamed E; Naglah, Abdelrahman A; Almehizia, Abdulrahman A; Naglah, Ahmed M; Fares, Mohamed; Tawfik, Haytham O; Eldehna, Wagdy M; Abdel-Aziz, Hatem A
信号转导
肿瘤
肿瘤免疫
发表日期：2026
文献求助 收藏

Synthesis of new trans-ferulic acid derivatives as potential anticancer agents and VEGFR-2 inhibitors

合成新型反式阿魏酸衍生物作为潜在的抗癌剂和VEGFR-2抑制剂

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d5md00980d
Mohie, Asmaa N; Doheim, Mahmoud A; El Masry, Ragab A; Gomaa, Ayman M; Salem, Rofaida; Tawfik, Haytham O; Eldehna, Wagdy M
EGFR
EGF
肿瘤
VEGF
肿瘤免疫
发表日期：2026
文献求助 收藏

Development of New Pyrazolo [3,4-b]Pyridine Derivatives as Potent Anti-Leukemic Agents and Topoisomerase IIα Inhibitors with Broad-Spectrum Cytotoxicity

开发新型吡唑并[3,4-b]吡啶衍生物作为强效抗白血病药物和具有广谱细胞毒性的拓扑异构酶IIα抑制剂

期刊:Pharmaceuticals
影响因子:4.8
doi:10.3390/ph18111770
Eldehna, Wagdy M; Tawfik, Haytham O; Veselá, Denisa; Vojáčková, Veronika; Negmeldin, Ahmed T; Elsayed, Zainab M; Majrashi, Taghreed A; Krňávková, Petra; Elbadawi, Mostafa M; Shaldam, Moataz A; Al-Ansary, Ghada H; Kryštof, Vladimír; Abdel-Aziz, Hatem A
细胞生物学
白血病
毒理研究
发表日期：2025
文献求助 收藏

Discovery of Novel Piperidinyl-Based Benzoxazole Derivatives as Anticancer Agents Targeting VEGFR-2 and c-Met Kinases

发现新型哌啶基苯并恶唑衍生物作为靶向VEGFR-2和c-Met激酶的抗癌药物

期刊:Pharmaceuticals
影响因子:4.8
doi:10.3390/ph18121875
Eldehna, Wagdy M; Elsayed, Zainab M; Elnagar, Mohamed R; El-Said, Ahmed H; Majrashi, Taghreed A; Negmeldin, Ahmed T; Saleh, Abdulrahman M; Elrayess, Ranza; Elnahriry, Khaled A; Chen, Zhi-Long; Elagawany, Mohamed; Tawfik, Haytham O
肿瘤
肿瘤免疫
信号转导
EGF
EGFR
VEGF
发表日期：2025
文献求助 收藏

Targeted synthesis of a trimethoxyphenyltetrahydropyrimidine analogue designed as a DNA intercalator: in silico, multi-spectroscopic, thermodynamic, and in vitro approaches

以DNA嵌入剂为设计目标的三甲氧基苯基四氢嘧啶类似物的靶向合成：计算机模拟、多光谱学、热力学和体外方法

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d5ra02179k
Al-Karmalawy, Ahmed A; Elmaaty, Ayman Abo; Magdy, Galal; Radwan, Aya Saad; Alnajjar, Radwan; Shaldam, Moataz A; Al Khatib, Arwa Omar; Almujri, Salem Salman; Abdullah Alzahrani, Abdullah Yahya; Tawfik, Haytham O
发表日期：2025
文献求助 收藏

Next-Generation Proteolysis-Targeting Chimeras in Precision Oncology: Multifunctional Designs, Emerging Modalities, and Translational Prospects in Targeted Protein Degradation

下一代蛋白水解靶向嵌合体在精准肿瘤学中的应用：多功能设计、新兴模式及靶向蛋白降解的转化前景

期刊:Drug Development Research
影响因子:4.2
doi:10.1002/ddr.70192
Nafie, Mohamed S; Diab, Mohamed K; Yassen, Asmaa S A; Elshamy, Amany M; El Tohamy, Mohamed R; Tawfik, Haytham O; Fahmy, Sherif Ashraf
蛋白降解
肿瘤
肿瘤免疫
发表日期：2025
文献求助 收藏

Pharmacophore modeling: advances and pitfalls

药效团模型：进展与不足

期刊:Frontiers in Molecular Biosciences
影响因子:4
doi:10.3389/fmolb.2025.1760982
Elsaka, Mahmoud Y; Taha, M Modather; Tayel, Amr; Tawfik, Haytham O; Ibrahim, Mahmoud A A; Shoeib, Tamer
发表日期：2025
文献求助 收藏

Donepezil-based rational design of N-substituted quinazolinthioacetamide candidates as potential acetylcholine esterase inhibitors for the treatment of Alzheimer's disease: in vitro and in vivo studies

基于多奈哌齐的N-取代喹唑啉硫代乙酰胺类化合物的合理设计：作为治疗阿尔茨海默病的潜在乙酰胆碱酯酶抑制剂：体外和体内研究

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d4md00778f
Al-Karmalawy, Ahmed A; Mohamed, Ahmed F; Shalaby, Heba Nasr; Elmaaty, Ayman Abo; El-Shiekh, Riham A; Zeidan, Mohamed A; Alnajjar, Radwan; Alzahrani, Abdullah Yahya Abdullah; Al Mughram, Mohammed H; Shaldam, Moataz A; Tawfik, Haytham O
阿尔茨海默症
发表日期：2025
文献求助 收藏