日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Contrasting Effects of Chronic Glucokinase Activation and Inhibition on Pancreatic Beta-Cell Function.

慢性葡萄糖激酶激活和抑制对胰岛β细胞功能的相反影响。

Lloyd Matthew, Vedovato Natascia, Mullan Samuel J, Elphick Alice, Dumenil Aerin J, Rufer Chantal, Title Alexandra C, Yesildag Burcak, Haythorne Elizabeth, Ashcroft Frances M

Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes

1型糖尿病中低血糖诱导的胰高血糖素分泌受损的根本原因是β细胞与δ细胞电耦合的丧失。

Thomas G Hill # ,Rui Gao # ,Anna Benrick ,Lakshmi Kothegala ,Nils Rorsman ,Cristiano Santos ,Samuel Acreman ,Linford J Briant ,Haiqiang Dou ,Nikhil R Gandasi ,Claudia Guida ,Elizabeth Haythorne ,Marsha Wallace ,Jakob G Knudsen ,Caroline Miranda ,Johan Tolö ,Anne Clark ,Lucy Davison ,Joachim Størling ,Andrei Tarasov ,Frances M Ashcroft ,Patrik Rorsman ,Quan Zhang

52,000 years of woolly rhinoceros population dynamics reveal extinction mechanisms

长达52000年的披毛犀种群动态研究揭示了灭绝机制

Fordham, Damien A; Brown, Stuart C; Canteri, Elisabetta; Austin, Jeremy J; Lomolino, Mark V; Haythorne, Sean; Armstrong, Edward; Bocherens, Hervé; Manica, Andrea; Rey-Iglesia, Alba; Rahbek, Carsten; Nogués-Bravo, David; Lorenzen, Eline D

Reconstructing colonization dynamics to establish how human activities transformed island biodiversity

重建殖民动态,以确定人类活动如何改变岛屿生物多样性

Tomlinson, Sean; Lomolino, Mark V; Anderson, Atholl; Austin, Jeremy J; Brown, Stuart C; Haythorne, Sean; Perry, George L W; Wilmshurst, Janet M; Wood, Jamie R; Fordham, Damien A

Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells

糖酵解改变会引发糖尿病 β 细胞中线粒体代谢受损和 mTORC1 激活

Elizabeth Haythorne, Matthew Lloyd, John Walsby-Tickle, Andrei I Tarasov, Jonas Sandbrink, Idoia Portillo, Raul Terron Exposito, Gregor Sachse, Malgorzata Cyranka, Maria Rohm, Patrik Rorsman, James McCullagh, Frances M Ashcroft

Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice

小鼠新生儿暂时性糖尿病点突变 (SUR1-R1183W) 的表型

Gregor Sachse, Elizabeth Haythorne, Peter Proks, Michelle Stewart, Heather Cater, Sian Ellard, Ben Davies, Frances M Ashcroft

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice

线粒体 Ca2+ 单向转运体的成孔亚基 MCU 是小鼠体内和体外正常葡萄糖刺激的胰岛素分泌所必需的

Eleni Georgiadou, Elizabeth Haythorne, Matthew T Dickerson, Livia Lopez-Noriega, Timothy J Pullen, Gabriela da Silva Xavier, Samuel P X Davis, Aida Martinez-Sanchez, Francesca Semplici, Rosario Rizzuto, James A McGinty, Paul M French, Matthew C Cane, David A Jacobson, Isabelle Leclerc, Guy A Rutter

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis

2型糖尿病基因产物STARD10是一种磷脂酰肌醇结合蛋白,可控制胰岛素分泌颗粒的生物合成。

Gaelle R Carrat,Elizabeth Haythorne,Alejandra Tomas,Leena Haataja,Andreas Müller,Peter Arvan,Alexandra Piunti,Kaiying Cheng,Mutian Huang,Timothy J Pullen,Eleni Georgiadou,Theodoros Stylianides,Nur Shabrina Amirruddin,Victoria Salem,Walter Distaso,Andrew Cakebread,Kate J Heesom,Philip A Lewis,David J Hodson,Linford J Briant,Annie C H Fung,Richard B Sessions,Fabien Alpy,Alice P S Kong,Peter I Benke,Federico Torta,Adrian Kee Keong Teo,Isabelle Leclerc,Michele Solimena,Dale B Wigley,Guy A Rutter

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

高血糖引起的钠依赖性 ATP 生成减少导致胰高血糖素分泌失调

Jakob G Knudsen, Alexander Hamilton, Reshma Ramracheya, Andrei I Tarasov, Melissa Brereton, Elizabeth Haythorne, Margarita V Chibalina, Peter Spégel, Hindrik Mulder, Quan Zhang, Frances M Ashcroft, Julie Adam, Patrik Rorsman

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

糖尿病导致胰腺 β 细胞线粒体代谢明显受到抑制

Elizabeth Haythorne, Maria Rohm, Martijn van de Bunt, Melissa F Brereton, Andrei I Tarasov, Thomas S Blacker, Gregor Sachse, Mariana Silva Dos Santos, Raul Terron Exposito, Simon Davis, Otto Baba, Roman Fischer, Michael R Duchen, Patrik Rorsman, James I MacRae, Frances M Ashcroft