日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Exploring a patient-specific in vitro pipeline for stratification and drug response prediction of microglia-based therapeutics

探索针对特定患者的体外筛选流程,用于对基于小胶质细胞的疗法进行分层和药物反应预测

Carla Cuní-López ,Romal Stewart ,Satomi Okano ,Garry L Redlich ,Mark W Appleby ,Anthony R White # ,Hazel Quek #

Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer's disease

用于阿尔茨海默病临床前研究的先进患者特异性小胶质细胞模型

Carla Cuní-López ,Romal Stewart ,Lotta E Oikari ,Tam Hong Nguyen ,Tara L Roberts ,Yifan Sun ,Christine C Guo ,Michelle K Lupton ,Anthony R White # ,Hazel Quek #

ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression

ALS 单核细胞衍生的小胶质细胞样细胞显示与疾病进展相关的细胞质 TDP-43 积累、DNA 损伤和细胞特异性吞噬功能受损

Hazel Quek, Carla Cuní-López, Romal Stewart, Tiziana Colletti, Antonietta Notaro, Tam Hong Nguyen, Yifan Sun, Christine C Guo, Michelle K Lupton, Tara L Roberts, Yi Chieh Lim, Lotta E Oikari, Vincenzo La Bella, Anthony R White

An Alzheimer's Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with Cognition

阿尔茨海默病患者来源的嗅觉干细胞模型揭示了与认知相关的基因表达变化

Laura M Rantanen ,Maina Bitar ,Riikka Lampinen ,Romal Stewart ,Hazel Quek ,Lotta E Oikari ,Carla Cunί-Lόpez ,Ratneswary Sutharsan ,Gayathri Thillaiyampalam ,Jamila Iqbal ,Daniel Russell ,Elina Penttilä ,Heikki Löppönen ,Juha-Matti Lehtola ,Toni Saari ,Sanna Hannonen ,Anne M Koivisto ,Larisa M Haupt ,Alan Mackay-Sim ,Alexandre S Cristino ,Katja M Kanninen ,Anthony R White

A robust approach to differentiate human monocyte-derived microglia from peripheral blood mononuclear cells

一种区分人类单核细胞衍生小胶质细胞与外周血单核细胞的稳健方法

Hazel Quek, Carla Cuní-López, Romal Stewart, Yi Chieh Lim, Tara L Roberts, Anthony R White

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone-Pyridylhydrazone Copper(II) Complex

硫代半卡巴腙-吡啶基腙铜(II)配合物的新型抗神经炎症特性

Xin Yi Choo ,Lachlan E McInnes ,Alexandra Grubman ,Joanna M Wasielewska ,Irina Belaya ,Emma Burrows ,Hazel Quek ,Jorge Cañas Martín ,Sanna Loppi ,Annika Sorvari ,Dzhessi Rait ,Andrew Powell ,Clare Duncan ,Jeffrey R Liddell ,Heikki Tanila ,Jose M Polo ,Tarja Malm ,Katja M Kanninen ,Paul S Donnelly ,Anthony R White

Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma

Curaxin CBL0137 和组蛋白去乙酰化酶抑制剂帕比司他双重靶向染色质稳定性,在神经母细胞瘤的临床前研究中显示出显著疗效。

Lin Xiao # ,Klaartje Somers # ,Jayne Murray ,Ruby Pandher ,Mawar Karsa ,Emma Ronca ,Angelika Bongers ,Rachael Terry ,Anahid Ehteda ,Laura D Gamble ,Natalia Issaeva ,Katerina I Leonova ,Aisling O'Connor ,Chelsea Mayoh ,Pooja Venkat ,Hazel Quek ,Jennifer Brand ,Frances K Kusuma ,Jessica A Pettitt ,Erin Mosmann ,Adam Kearns ,Georgina Eden ,Stephanie Alfred ,Sophie Allan ,Lei Zhai ,Alvin Kamili ,Andrew J Gifford ,Daniel R Carter ,Michelle J Henderson ,Jamie I Fletcher ,Glenn Marshall ,Ricky W Johnstone ,Anthony J Cesare ,David S Ziegler ,Andrei V Gudkov ,Katerina V Gurova ,Murray D Norris # ,Michelle Haber #

The Role of Chaperone-Mediated Autophagy in Bortezomib Resistant Multiple Myeloma

分子伴侣介导的自噬在硼替佐米耐药多发性骨髓瘤中的作用

Nicholas Nikesitch, Patricia Rebeiro, Lye Lin Ho, Srinivasa Pothula, Xin Maggie Wang, Tiffany Khong, Hazel Quek, Andrew Spencer, Cheok Soon Lee, Tara L Roberts, Silvia C W Ling

Regulation of RNA degradation pathways during the lipopolysaccharide response in Macrophages

巨噬细胞脂多糖反应过程中 RNA 降解途径的调节

Hui-Chi Lai, Alexander James, John Luff, Paul De Souza, Hazel Quek, Uda Ho, Martin F Lavin, Tara L Roberts

Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore

利用聚醚离子载体同时靶向胶质母细胞瘤中的 DNA 复制和同源重组

Yi Chieh Lim, Kathleen S Ensbey, Carolin Offenhäuser, Rochelle C J D'souza, Jason K Cullen, Brett W Stringer, Hazel Quek, Zara C Bruce, Amanda Kijas, Valentina Cianfanelli, Bijan Mahboubi, Fiona Smith, Rosalind L Jeffree, Lisa Wiesmüeller, Adrian P Wiegmans, Amanda Bain, Fanny J Lombard, Tara L Robe