Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency
siRNA的非环状丝氨醇核酸修饰可克服种子区介导的脱靶效应,同时保持效力。
期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkag345
Chickering, Tyler; Harp, Joel M; Jiang, Yongfeng; Qin, June; He, Guo; Hyde, Sarah; Ihlefeld, Audrey; Janas, Maja; O'Flaherty, Derek K; Schofield, Sally; Szeto, John; Theile, Christopher S; Charissé, Klaus; Jadhav, Vasant; Maier, Martin A; Manoharan, Muthiah; Egli, Martin; Schlegel, Mark K