日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Neutralizing Antibodies Against Factor VIII Can Occur Through a Non-Germinal Center Pathway

针对因子VIII的中和抗体可通过非生发中心途径产生

Patel, Seema R; Lundgren, Taran S; Baldwin, Wallace Hunter; Cox, Courtney; Parker, Ernest T; Healey, John F; Jajosky, Ryan P; Zerra, Patricia E; Josephson, Cassandra D; Doering, Christopher B; Stowell, Sean R; Meeks, Shannon L

Removal of single-site N-linked glycans on factor VIII alters binding of domain-specific monoclonal antibodies.

去除 VIII 因子上的单一位点 N-连接糖链会改变结构域特异性单克隆抗体的结合

Ito Jasmine, Baldwin Wallace Hunter, Cox Courtney, Healey John F, Parker Ernest T, Legan Emily R, Li Renhao, Gill Surinder, Batsuli Glaivy

Engineering a Therapeutic Protein to Enhance the Study of Anti-Drug Immunity

工程化治疗性蛋白质以加强抗药物免疫的研究

Zerra, Patricia E; Parker, Ernest T; Baldwin, Wallace Hunter; Healey, John F; Patel, Seema R; McCoy, James W; Cox, Courtney; Stowell, Sean R; Meeks, Shannon L

Sedimentation Velocity Analytical Ultracentrifugation of Oxidized Recombinant Full-Length Factor VIII

氧化重组全长因子VIII的沉降速度分析超速离心

Zakas, Philip M; Healey, John F; Smith, Ian W; Lillicrap, David; Lollar, Pete

Gene editing in CHO cells to prevent proteolysis and enhance glycosylation: Production of HIV envelope proteins as vaccine immunogens

利用基因编辑技术在CHO细胞中抑制蛋白水解并增强糖基化:生产HIV包膜蛋白作为疫苗免疫原

Li, Sophia W; Wright, Meredith; Healey, John F; Hutchinson, Jennie M; O'Rourke, Sara; Mesa, Kathryn A; Lollar, Pete; Berman, Phillip W

The diversity of the immune response to the A2 domain of human factor VIII

人类凝血因子VIII A2结构域免疫反应的多样性

Markovitz, Rebecca C; Healey, John F; Parker, Ernest T; Meeks, Shannon L; Lollar, Pete

Characterization and solution structure of the factor VIII C2 domain in a ternary complex with classical and non-classical inhibitor antibodies

对VIII因子C2结构域与经典和非经典抑制抗体形成的三元复合物进行表征和溶液结构分析

Walter, Justin D; Werther, Rachel A; Polozova, Maria S; Pohlman, Julie; Healey, John F; Meeks, Shannon L; Lollar, Pete; Spiegel, P Clint Jr

A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function

在小鼠模型中,因子VIII免疫原性的一个主要决定因素与其促凝血功能无关。

Meeks, Shannon L; Cox, Courtney L; Healey, John F; Parker, Ernest T; Doshi, Bhavya S; Gangadharan, Bagirath; Barrow, Rachel T; Lollar, Pete

Factor VIII A3 domain substitution N1922S results in hemophilia A due to domain-specific misfolding and hyposecretion of functional protein

VIII因子A3结构域N1922S突变导致血友病A,这是由于该结构域特异性错误折叠和功能性蛋白分泌不足所致。

Summers, Ryan J; Meeks, Shannon L; Healey, John F; Brown, Harrison C; Parker, Ernest T; Kempton, Christine L; Doering, Christopher B; Lollar, Pete

The comparative immunogenicity of human and porcine factor VIII in haemophilia A mice

人源和猪源VIII因子在A型血友病小鼠中的免疫原性比较

Healey, John F; Parker, Ernest T; Barrow, Rachel T; Langley, Travis J; Church, William R; Lollar, Pete