日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

在粘蛋白产生细胞中,IRE1β 介导的未折叠蛋白反应受到伴侣 AGR2 的抑制

Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding, Stephen H McLaughlin, Sophie Janssens, David Ron

A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

全基因组 CRISPR/Cas9 筛选鉴定出钙网蛋白是 ATF6α 的选择性抑制因子

Joanne Tung, Lei Huang, Ginto George, Heather P Harding, David Ron, Adriana Ordonez

Protocol for iterative enrichment of integrated sgRNAs via derivative CRISPR-Cas9 libraries from genomic DNA of sorted fixed cells

利用衍生 CRISPR-Cas9 文库从分选固定细胞的基因组 DNA 中迭代富集整合的 sgRNA 的方案

Adriana Ordóñez ,David Ron ,Heather P Harding

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response

通过 eIF2γ 进行底物募集可增强全磷酸酶的催化效率,从而终止综合应激反应

Yahui Yan, Maithili Shetty, Heather P Harding, Ginto George, Alisa Zyryanova, Katherine Labbé, Amirhossein Mafi, Qi Hao, Carmela Sidrauski, David Ron

Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP

人类内质网分子伴侣 BiP AMPylation 失调导致婴儿期发病的糖尿病

Luke A Perera #, Andrew T Hattersley #, Heather P Harding #, Matthew N Wakeling #, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron #, Elisa De Franco #

ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B

ISRIB 通过变构拮抗磷酸化 eIF2 对 eIF2B 的抑制作用来减弱综合应激反应

Alisa F Zyryanova, Kazuhiro Kashiwagi, Claudia Rato, Heather P Harding, Ana Crespillo-Casado, Luke A Perera, Ayako Sakamoto, Madoka Nishimoto, Mayumi Yonemochi, Mikako Shirouzu, Takuhiro Ito, David Ron

Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

货物受体辅助内质网输出致病α1-抗胰蛋白酶聚合物

Adriana Ordóñez, Heather P Harding, Stefan J Marciniak, David Ron

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

GDF15在小鼠和人类中提供营养应激的内分泌信号

Satish Patel,Anna Alvarez-Guaita,Audrey Melvin,Debra Rimmington,Alessia Dattilo,Emily L Miedzybrodzka,Irene Cimino,Anne-Catherine Maurin,Geoffrey P Roberts,Claire L Meek,Samuel Virtue,Lauren M Sparks,Stephanie A Parsons,Leanne M Redman,George A Bray,Alice P Liou,Rachel M Woods,Sion A Parry,Per B Jeppesen,Anders J Kolnes,Heather P Harding,David Ron,Antonio Vidal-Puig,Frank Reimann,Fiona M Gribble,Carl J Hulston,I Sadaf Farooqi,Pierre Fafournoux,Steven R Smith,Jorgen Jensen,Danna Breen,Zhidan Wu,Bei B Zhang,Anthony P Coll,David B Savage,Stephen O'Rahilly

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

核糖体 P 柄将哺乳动物细胞中的氨基酸饥饿与 GCN2 激活联系起来

Heather P Harding, Adriana Ordonez, Felicity Allen, Leopold Parts, Alison J Inglis, Roger L Williams, David Ron

A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response

蛋白辅助伴侣招募 BiP 使 IRE1 单体化并抑制未折叠蛋白反应

Niko Amin-Wetzel, Reuben A Saunders, Maarten J Kamphuis, Claudia Rato, Steffen Preissler, Heather P Harding, David Ron