Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition
区域性输注C类TLR9激动剂可增强肝肿瘤微环境重编程和减少MDSC,从而提高对全身性检查点抑制剂的反应性。
期刊:Cancer Gene Therapy
影响因子:5
doi:10.1038/s41417-022-00484-z
Ghosh, Chandra C; Heatherton, Kara R; Connell, Kyle P O'; Alexander, Ian S; Greer, Deborah A; LaPorte, Jason; Guha, Prajna; Cox, Bryan F; Katz, Steven C