日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multi-laboratory comparisons of manual patch clamp hERG data generated using standardized protocols and following ICH S7B Q&A 2.1 best practices

使用标准化方案并遵循ICH S7B问答2.1最佳实践,对手动膜片钳hERG数据进行多实验室比较。

Alvarez Baron, Claudia; Zhao, Jun; Yu, Huimei; Ren, Ming; Thiebaud, Nicolas; Guo, Donglin; Vegesna, Giri; Hsiao, Cheng-Hui; DePalma, Ryan; Mistry, Sabyasachy; Tariq, Isra; Roni, Md Shadiqur Rashid; Ismaiel, Omnia A; Matta, Murali K; Patel, Vikram; Mashaee, Manni; Vicente, Jose; Johannesen, Lars; Sheng, Jiansong; Hebeisen, Simon; Kramer, James; Bruening-Wright, Andrew; Nakano, Koji; Matsukawa, Hiroshi; Pierson, Jennifer Beck; Wu, Wendy W

Testing the nonclinical Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm with an established anti-seizure medication: Levetiracetam case study

利用已上市的抗癫痫药物左乙拉西坦测试非临床综合体外致心律失常检测 (CiPA) 方法:病例研究

Delaunois, Annie; Mathy, François-Xavier; Cornet, Miranda; Gryshkova, Vitalina; Korlowski, Chloé; Bonfitto, François; Koch, Juliane; Schlit, Anne-Françoise; Hebeisen, Simon; Passini, Elisa; Rodriguez, Blanca; Valentin, Jean-Pierre

Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off-label in the first wave of COVID-19

应用CiPA方法评估一些在COVID-19第一波疫情期间超适应症使用抗疟药的心脏致心律失常风险

Delaunois, Annie; Abernathy, Matthew; Anderson, Warren D; Beattie, Kylie A; Chaudhary, Khuram W; Coulot, Julie; Gryshkova, Vitalina; Hebeisen, Simon; Holbrook, Mark; Kramer, James; Kuryshev, Yuri; Leishman, Derek; Lushbough, Isabel; Passini, Elisa; Redfern, Will S; Rodriguez, Blanca; Rossman, Eric I; Trovato, Cristian; Wu, Caiyun; Valentin, Jean-Pierre

Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.

药物对重组细胞中人类心脏电流影响的自动膜片钳评估的跨站点和跨平台变异性

Kramer James, Himmel Herbert M, Lindqvist Anders, Stoelzle-Feix Sonja, Chaudhary Khuram W, Li Dingzhou, Bohme Georg Andrees, Bridgland-Taylor Matthew, Hebeisen Simon, Fan Jingsong, Renganathan Muthukrishnan, Imredy John, Humphries Edward S A, Brinkwirth Nina, Strassmaier Tim, Ohtsuki Atsushi, Danker Timm, Vanoye Carlos, Polonchuk Liudmila, Fermini Bernard, Pierson Jennifer Beck, Gintant Gary

Corrigendum to "A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm" [Toxicology and Applied Pharmacology volume 394C (2020) 114961]

对“评估 hERG 阻滞效力的系统策略及其在新的心脏安全范式中的意义”的更正[毒理学和应用药理学卷 394C (2020) 114961]

Ridder, Bradley J; Leishman, Derek J; Bridgland-Taylor, Matthew; Samieegohar, Mohammadreza; Han, Xiaomei; Wu, Wendy W; Randolph, Aaron; Tran, Phu; Sheng, Jiansong; Danker, Timm; Lindqvist, Anders; Konrad, Daniel; Hebeisen, Simon; Polonchuk, Liudmila; Gissinger, Evgenia; Renganathan, Muthukrishnan; Koci, Bryan; Wei, Haiyang; Fan, Jingsong; Levesque, Paul; Kwagh, Jae; Imredy, John; Zhai, Jin; Rogers, Marc; Humphries, Edward; Kirby, Robert; Stoelzle-Feix, Sonja; Brinkwirth, Nina; Rotordam, Maria Giustina; Becker, Nadine; Friis, Søren; Rapedius, Markus; Goetze, Tom A; Strassmaier, Tim; Okeyo, George; Kramer, James; Kuryshev, Yuri; Wu, Caiyun; Himmel, Herbert; Mirams, Gary R; Strauss, David G; Bardenet, Remi; Li, Zhihua

A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.

评估 hERG 阻滞效力的系统策略及其在新心脏安全范式中的意义

Ridder Bradley J, Leishman Derek J, Bridgland-Taylor Matthew, Samieegohar Mohammadreza, Han Xiaomei, Wu Wendy W, Randolph Aaron, Tran Phu, Sheng Jiansong, Danker Timm, Lindqvist Anders, Konrad Daniel, Hebeisen Simon, Polonchuk Liudmila, Gissinger Evgenia, Renganathan Muthukrishnan, Koci Bryan, Wei Haiyang, Fan Jingsong, Levesque Paul, Kwagh Jae, Imredy John, Zhai Jin, Rogers Marc, Humphries Edward, Kirby Robert, Stoelzle-Feix Sonja, Brinkwirth Nina, Rotordam Maria Giustina, Becker Nadine, Friis Søren, Rapedius Markus, Goetze Tom A, Strassmaier Tim, Okeyo George, Kramer James, Kuryshev Yuri, Wu Caiyun, Himmel Herbert, Mirams Gary R, Strauss David G, Bardenet Rémi, Li Zhihua

TPK1 is a vacuolar ion channel different from the slow-vacuolar cation channel

TPK1是一种液泡离子通道,不同于慢速液泡阳离子通道。

Bihler, Hermann; Eing, Christian; Hebeisen, Simon; Roller, Anja; Czempinski, Katrin; Bertl, Adam