日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: implications for the interplay between human DNA damage tolerance pathways

通过用Rad51替换RPA，可以消除PCNA环绕引物/模板连接处：这对人类DNA损伤耐受通路之间的相互作用具有重要意义

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf1478
Norris, Jessica L; Rogers, Lindsey O; Young, Grace; Pytko, Kara G; Dannenberg, Rachel L; Perreault, Samuel; Kaushik, Vikas; Antony, Edwin; Hedglin, Mark
PCNA
信号转导
毒理研究
发表日期：2026
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Structure of the human CTF18-RFC clamp loader bound to PCNA

人类 CTF18-RFC 钳状加载蛋白与 PCNA 结合的结构

期刊:Elife
影响因子:6.4
doi:10.7554/eLife.103493
Briola, Giuseppina R; Tehseen, Mohammad; Al-Amodi, Amani; Young, Grace; Danazumi, Ammar U; Nguyen, Phong Quoc; Savva, Christos G; Hedglin, Mark; Hamdan, Samir M; De Biasio, Alfredo
CTF18
PCNA
发表日期：2026
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Fork Reversal Safeguards Epigenetic Inheritance During Replication Stress.

复制叉逆转可在复制压力下保护表观遗传。

期刊:
影响因子:
doi:10.21203/rs.3.rs-8544414/v1
Wu Qiong, Zhou Caixian, Dou Yue, Martin Nadia I, Gwit Maria, Lee Tae-Hee, Hedglin Mark, Chen Roséa, Zhu Ke, Zhang Tianpeng, Tang Shangming, Zhang Tian, Weaver Tyler M, Liu Wenpeng
表观遗传
发表日期：2026
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Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex

治疗性6-硫代脱氧鸟苷通过诱导非生产性停滞端粒酶复合物来抑制癌细胞中的端粒延长。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-66534-w
Sanford, Samantha L; Badstübner, Mareike; Gerber, Michael; Mannherz, William; Lampl, Noah; Dannenberg, Rachel; Hinchie, Angela; Schaich, Matthew A; Myong, Sua; Hedglin, Mark; Agarwal, Suneet; Alder, Jonathan K; Stone, Michael D; Opresko, Patricia L
细胞生物学
肿瘤
肿瘤免疫
发表日期：2025
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A human high-fidelity DNA polymerase holoenzyme has a wide range of lesion bypass activities

人类高保真DNA聚合酶全酶具有广泛的损伤旁路修复活性。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf646
Dannenberg, Rachel L; Cardina, Joseph A; Washington, Helen; Gao, Shijun; Greenberg, Marc M; Hedglin, Mark
发表日期：2025
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Replicative DNA polymerase epsilon and delta holoenzymes show wide-ranging inhibition at G-quadruplexes in the human genome

复制型DNA聚合酶ε和δ全酶在人类基因组中对G-四链体表现出广泛的抑制作用

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf352
Hile, Suzanne E; Weissensteiner, Matthias H; Pytko, Kara G; Dahl, Joseph; Kejnovsky, Eduard; Kejnovská, Iva; Hedglin, Mark; Georgakopoulos-Soares, Ilias; Makova, Kateryna D; Eckert, Kristin A
发表日期：2025
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Cryo-EM structure of apo-form human DNA polymerase δ elucidates its minimal DNA synthesis activity without PCNA

冷冻电镜结构分析表明，无配体形式的人类DNA聚合酶δ在没有PCNA的情况下，其DNA合成活性极低。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.108342
Shin, Yeonoh; Hedglin, Mark; Murakami, Katsuhiko S
PCNA
发表日期：2025
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PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: Implications for the interplay between human DNA damage tolerance pathways

通过用Rad51替换RPA，可以消除PCNA环绕引物/模板连接处：这对人类DNA损伤耐受通路之间的相互作用具有重要意义

期刊:
影响因子:
doi:10.1101/2025.03.27.645792
Norris, Jessica L; Rogers, Lindsey O; Young, Grace; Pytko, Kara G; Dannenberg, Rachel L; Perreault, Samuel; Kaushik, Vikas; Antony, Edwin; Hedglin, Mark
信号转导
PCNA
毒理研究
发表日期：2025
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Structure of the human CTF18-RFC clamp loader bound to PCNA

人类 CTF18-RFC 钳状加载蛋白与 PCNA 结合的结构

期刊:
影响因子:
doi:10.1101/2024.05.08.593111
Briola, Giuseppina R; Tehseen, Muhammad; Al-Amodi, Amani; Young, Grace; Danazumi, Ammar U; Nguyen, Phong Quoc; Savva, Christos G; Hedglin, Mark; Hamdan, Samir M; De Biasio, Alfredo
PCNA
CTF18
发表日期：2025
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Chemotherapeutic 6-thio-2'-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex

化疗药物6-硫代-2'-脱氧鸟苷通过诱导形成非生产性端粒结合端粒酶复合物，选择性地靶向并抑制端粒酶。

期刊:
影响因子:
doi:10.1101/2025.02.05.636339
Sanford, Samantha L; Badstübner, Mareike; Gerber, Michael; Mannherz, William; Lampl, Noah; Dannenberg, Rachel; Hinchie, Angela; Schaich, Matthew A; Myong, Sua; Hedglin, Mark; Agarwal, Suneet; Alder, Jonathan K; Stone, Michael D; Opresko, Patricia L
发表日期：2025
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