日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Genotype and transcript processing of the tumour necrosis factor receptor TNFRSF1A in epithelial cells: implications for survival in cystic fibrosis.

肿瘤坏死因子受体 TNFRSF1A 在上皮细胞中的基因型和转录加工：对囊性纤维化患者生存的影响

期刊:EBioMedicine
影响因子:10.8
doi:10.1016/j.ebiom.2025.105848
Uden Alexander, Dunsche Inga, Janciauskiene Sabina, Gräber Simon, Feng Longhua, Tamm Stephanie, Hedtfeld Silke, Stege Gesa, Jahn Kirsten, Kontsendorn Julia, Alfeis Nadine, Kühbandner Iris, Minso Rebecca, Dopfer Christian, Griese Matthias, Sommerburg Olaf, Ringshausen Felix C, Nährlich Lutz, Hansen Gesine, Welte Tobias, Braubach Peter, Mall Marcus A, Tümmler Burkhard, Dittrich Anna-Maria, Stanke Frauke
肿瘤
发表日期：2025
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Human induced pluripotent stem cells for in vitro modeling of impaired mucociliary clearance in cystic fibrosis lung disease.

利用人类诱导多能干细胞进行体外模型研究囊性纤维化肺病中黏液纤毛清除功能障碍。

期刊:Stem Cell Research & Therapy
影响因子:7.3
doi:10.1186/s13287-025-04737-0
Klassen Mark-Christian, Balázs Anita, Zöllner Janina, Cleve Nicole, Czichon Laurien, von Schledorn Laura, Hegermann Jan, Nawroth Janna C, Roth Doris, Mielenz Mia, Hedtfeld Silke, Stanke Frauke, Rubil Tihomir, Ius Fabio, Jonigk Danny, Hanrahan John W, Ruhparwar Arjang, Olmer Ruth, Mall Marcus A, Merkert Sylvia, Martin Ulrich
Human
发育与干细胞
干细胞
发表日期：2025
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The Cystic Fibrosis Upper and Lower Airway Metagenome

囊性纤维化上呼吸道和下呼吸道宏基因组

期刊:Microbiology Spectrum
影响因子:3.8
doi:10.1128/spectrum.03633-22
Pienkowska, Katarzyna; Pust, Marie-Madlen; Gessner, Margaux; Gaedcke, Svenja; Thavarasa, Ajith; Rosenboom, Ilona; Morán Losada, Patricia; Minso, Rebecca; Arnold, Christin; Hedtfeld, Silke; Dorda, Marie; Wiehlmann, Lutz; Mainz, Jochen G; Klockgether, Jens; Tümmler, Burkhard
发表日期：2023
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The cystic fibrosis lower airways microbial metagenome

囊性纤维化下呼吸道微生物宏基因组

期刊:Erj Open Research
影响因子:4
doi:10.1183/23120541.00096-2015
Moran Losada, Patricia; Chouvarine, Philippe; Dorda, Marie; Hedtfeld, Silke; Mielke, Samira; Schulz, Angela; Wiehlmann, Lutz; Tümmler, Burkhard
微生物学
发表日期：2016
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The CF-modifying gene EHF promotes p.Phe508del-CFTR residual function by altering protein glycosylation and trafficking in epithelial cells

CF修饰基因EHF通过改变上皮细胞中的蛋白质糖基化和转运，促进p.Phe508del-CFTR的残余功能。

期刊:European Journal of Human Genetics
影响因子:4.6
doi:10.1038/ejhg.2013.209
Stanke, Frauke; van Barneveld, Andrea; Hedtfeld, Silke; Wölfl, Stefan; Becker, Tim; Tümmler, Burkhard
上皮细胞
CFTR
细胞生物学
发表日期：2014
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CLCA4 variants determine the manifestation of the cystic fibrosis basic defect in the intestine

CLCA4基因变异决定了囊性纤维化基本缺陷在肠道中的表现。

期刊:European Journal of Human Genetics
影响因子:4.6
doi:10.1038/ejhg.2012.234
Kolbe, Ernst-Wolfgang; Tamm, Stephanie; Hedtfeld, Silke; Becker, Tim; Tümmler, Burkhard; Stanke, Frauke
CLCA4
CLC
发表日期：2013
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Initial interrogation, confirmation and fine mapping of modifying genes: STAT3, IL1B and IFNGR1 determine cystic fibrosis disease manifestation

初步探究、确认和精细定位修饰基因：STAT3、IL1B 和 IFNGR1 决定囊性纤维化疾病的表现。

期刊:European Journal of Human Genetics
影响因子:4.6
doi:10.1038/ejhg.2011.129
Labenski, Heike; Hedtfeld, Silke; Becker, Tim; Tümmler, Burkhard; Stanke, Frauke
IFNGR1
IL1B
JAK/STAT
IFNG
STAT3
IFNGR
发表日期：2011
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Genes that determine immunology and inflammation modify the basic defect of impaired ion conductance in cystic fibrosis epithelia

决定免疫和炎症的基因会改变囊性纤维化上皮细胞离子传导受损的基本缺陷。

期刊:Journal of Medical Genetics
影响因子:3.7
doi:10.1136/jmg.2010.080937
Stanke, Frauke; Becker, Tim; Kumar, Vinod; Hedtfeld, Silke; Becker, Christian; Cuppens, Harry; Tamm, Stephanie; Yarden, Jennifer; Laabs, Ulrike; Siebert, Benny; Fernandez, Luis; Macek, Milan Jr; Radojkovic, Dragica; Ballmann, Manfred; Greipel, Joachim; Cassiman, Jean-Jacques; Wienker, Thomas F; Tümmler, Burkhard
炎症
炎症/感染
上皮细胞
细胞生物学
免疫/内分泌
发表日期：2011
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An association study on contrasting cystic fibrosis endophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic fibrosis disease severity and CFTR mediated residual chloride secretion

一项关于囊性纤维化不同内表型的关联研究发现，KRT8而非KRT18是囊性纤维化疾病严重程度和CFTR介导的残余氯离子分泌的调节因子。

期刊:BMC Medical Genetics
影响因子:
doi:10.1186/1471-2350-12-62
Stanke, Frauke; Hedtfeld, Silke; Becker, Tim; Tümmler, Burkhard
CFTR
发表日期：2011
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Differential decay of parent-of-origin-specific genomic sharing in cystic fibrosis-affected sib pairs maps a paternally imprinted locus to 7q34

囊性纤维化患儿同胞对中亲本来源特异性基因组共享的差异性衰减将父系印记位点定位于 7q34

期刊:European Journal of Human Genetics
影响因子:4.6
doi:10.1038/ejhg.2009.229
Stanke, Frauke; Davenport, Colin; Hedtfeld, Silke; Tümmler, Burkhard
发表日期：2010
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