Hee-Sik相关文献与解析，生知库 | 链接生命科学的每一步

Chlamy_ChloroPred: a deep learning-based, highly accurate binary classifier for chloroplast protein prediction in the model microalga, Chlamydomonas reinhardtii, with potential cross-proteome versatility

Chlamy_ChloroPred：一种基于深度学习的高精度二元分类器，用于预测模式微藻莱茵衣藻的叶绿体蛋白，具有潜在的跨蛋白质组通用性。

doi:10.3389/fmicb.2026.1744805

Choi, Hong Il; Lee, Sung Ho; Lee, Il Hyung; Lee, Yong Jae; Yun, Jin-Ho; Choi, Dong-Yun; Cho, Dae-Hyun; Shin, Bum-Soo; Chun, Junyoung; Lee, Dong Won; Kim, Hee-Sik

发表日期：2026

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Cas9-mediated gene-editing frequency in microalgae is doubled by harnessing the interaction between importin α and phytopathogenic NLSs

利用输入蛋白α与植物病原体核定位信号（NLS）之间的相互作用，Cas9介导的微藻基因编辑频率提高了一倍。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2415072122

Le, Trang Thi; Choi, Hong Il; Kim, Ji Won; Yun, Jin-Ho; Lee, Yoon Hyeok; Jeon, Eun Jung; Kwon, Kil Koang; Cho, Dae-Hyun; Choi, Dong-Yun; Park, Su-Bin; Yoon, Hyang Ran; Lee, Jeongmi; Sim, Eun Jeong; Lee, Yong Jae; Kim, Hee-Sik

Efficient secretory production of recombinant proteins in microalgae using an exogenous signal peptide

利用外源信号肽在微藻中高效分泌表达重组蛋白

期刊:Frontiers in Microbiology

影响因子:4.5

doi:10.3389/fmicb.2025.1603204

Le, Trang Thi; Tran, Quynh-Giao; Park, Su-Bin; Yoon, Hyang Ran; Choi, Dong-Yun; Cho, Dae-Hyun; Yun, Jin-Ho; Choi, Hong Il; Kim, Hee-Sik; Lee, Yong Jae

信号转导

发表日期：2025

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Cell-Penetrating Peptide-Based Triple Nanocomplex Enables Efficient Nuclear Gene Delivery in Chlamydomonas reinhardtii

基于细胞穿透肽的三元纳米复合物可实现莱茵衣藻中高效的核基因递送

期刊:Biotechnology and Bioengineering

影响因子:3.6

doi:10.1002/bit.29019

Sim, Eun Jeong; Tran, Quynh-Giao; Lee, Yu Rim; Le, Trang Thi; Yoon, Hyang Ran; Choi, Dong-Yun; Cho, Dae-Hyun; Yun, Jin-Ho; Il Choi, Hong; Kim, Hee-Sik; Lee, Yong Jae

细胞生物学

发表日期：2025

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Lactobacillus brevis-Derived Exosomes Enhance Skin Barrier Integrity by Upregulating Key Barrier-Related Proteins.

短乳杆菌来源的外泌体通过上调关键屏障相关蛋白来增强皮肤屏障完整性

期刊:Clinical Cosmetic and Investigational Dermatology

影响因子:2.2

doi:10.2147/CCID.S512793

Cho Yong-Han, Kim Ji-Woo, Kim Nari, Kim Hee-Sik, Jang Jun-Hwan, Bae Jun-Tae, Kim Wanil

Towards maximizing biomass and lipid productivity: high-throughput screening assay for prospecting heterotrophic growth for new microalgal isolates

为最大限度地提高生物量和脂质产量：用于筛选异养生长新型微藻分离株的高通量筛选方法

期刊:Microbial Cell Factories

影响因子:4.9

doi:10.1186/s12934-024-02550-7

Park, Su-Bin; Lee, Yu Rim; Yun, Jin-Ho; Choi, Hong Il; Sim, Eun Jeong; Choi, Dong-Yun; Cho, Dae-Hyun; Kim, Hee-Sik; Lee, Yong Jae

发表日期：2024

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High-throughput optimization of organic carbon provision strategies enables enhanced arachidonic acid production in novel microalgae

通过高通量优化有机碳供应策略，可以提高新型微藻中花生四烯酸的产量。

期刊:Microbial Cell Factories

影响因子:4.9

doi:10.1186/s12934-024-02560-5

Sim, Eun Jeong; Lee, Yu Rim; Park, Su-Bin; Kim, Geonwoo; Shin, Bum-Soo; Yun, Jin-Ho; Choi, Hong Il; Choi, Dong-Yun; Cho, Dae-Hyun; Kim, Hee-Sik; Lee, Yong Jae

发表日期：2024

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7 S,15 R-Dihydroxy-16 S,17 S-epoxy-docosapentaenoic Acid Overcomes Chemoresistance of 5-Fluorouracil by Suppressing the Infiltration of Tumor-Associated Macrophages and Inhibiting the Activation of Cancer Stem Cells in a Colorectal Cancer Xenograft Model

S,15 R-二羟基-16 S,17 S-环氧-二十二碳五烯酸通过抑制肿瘤相关巨噬细胞的浸润和抑制结直肠癌异种移植模型中癌症干细胞的激活来克服 5-氟尿嘧啶的化学耐药性

期刊:Marine Drugs

影响因子:4.9

doi:10.3390/md21020080

Yan Su, Hack Sun Choi, Jong Hyun Choi, Hee-Sik Kim, Yong-Suk Jang, Jeong-Woo Seo

Effects of Fish Oil, Lipid Mediators, Derived from Docosahexaenoic Acid, and Their Co-Treatment against Lipid Metabolism Dysfunction and Inflammation in HFD Mice and HepG2 Cells

鱼油、二十二碳六烯酸衍生的脂质介质及其联合治疗对 HFD 小鼠和 HepG2 细胞脂质代谢障碍和炎症的影响

期刊:Nutrients

影响因子:4.8

doi:10.3390/nu15020427

Yan Su, Hack-Sun Choi, Jong-Hyun Choi, Hee-Sik Kim, Gil-Yong Lee, Hee-Won Cho, Heonsik Choi, Yong-Suk Jang, Jeong-Woo Seo

The sugar transporter STP1-driven trophic conversion of Chlamydomonas reinhardtii

莱茵衣藻的糖转运蛋白STP1驱动的营养转化

Chlamy_ChloroPred: a deep learning-based, highly accurate binary classifier for chloroplast protein prediction in the model microalga, Chlamydomonas reinhardtii, with potential cross-proteome versatility

Chlamy_ChloroPred：一种基于深度学习的高精度二元分类器，用于预测模式微藻莱茵衣藻的叶绿体蛋白，具有潜在的跨蛋白质组通用性。

Cas9-mediated gene-editing frequency in microalgae is doubled by harnessing the interaction between importin α and phytopathogenic NLSs

利用输入蛋白α与植物病原体核定位信号（NLS）之间的相互作用，Cas9介导的微藻基因编辑频率提高了一倍。

Efficient secretory production of recombinant proteins in microalgae using an exogenous signal peptide

利用外源信号肽在微藻中高效分泌表达重组蛋白

Cell-Penetrating Peptide-Based Triple Nanocomplex Enables Efficient Nuclear Gene Delivery in Chlamydomonas reinhardtii

基于细胞穿透肽的三元纳米复合物可实现莱茵衣藻中高效的核基因递送

Lactobacillus brevis-Derived Exosomes Enhance Skin Barrier Integrity by Upregulating Key Barrier-Related Proteins.

短乳杆菌来源的外泌体通过上调关键屏障相关蛋白来增强皮肤屏障完整性

Towards maximizing biomass and lipid productivity: high-throughput screening assay for prospecting heterotrophic growth for new microalgal isolates

为最大限度地提高生物量和脂质产量：用于筛选异养生长新型微藻分离株的高通量筛选方法

High-throughput optimization of organic carbon provision strategies enables enhanced arachidonic acid production in novel microalgae

通过高通量优化有机碳供应策略，可以提高新型微藻中花生四烯酸的产量。

7 S,15 R-Dihydroxy-16 S,17 S-epoxy-docosapentaenoic Acid Overcomes Chemoresistance of 5-Fluorouracil by Suppressing the Infiltration of Tumor-Associated Macrophages and Inhibiting the Activation of Cancer Stem Cells in a Colorectal Cancer Xenograft Model

S,15 R-二羟基-16 S,17 S-环氧-二十二碳五烯酸通过抑制肿瘤相关巨噬细胞的浸润和抑制结直肠癌异种移植模型中癌症干细胞的激活来克服 5-氟尿嘧啶的化学耐药性

Effects of Fish Oil, Lipid Mediators, Derived from Docosahexaenoic Acid, and Their Co-Treatment against Lipid Metabolism Dysfunction and Inflammation in HFD Mice and HepG2 Cells

鱼油、二十二碳六烯酸衍生的脂质介质及其联合治疗对 HFD 小鼠和 HepG2 细胞脂质代谢障碍和炎症的影响