日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Coexistent PTEN and PIK3CA alterations hyperactivate mTORC1 signaling in endometrial cancers and cause their selective sensitivity to mTORC1 inhibition

PTEN 和 PIK3CA 的共存改变会过度激活子宫内膜癌中的 mTORC1 信号通路,并导致其对 mTORC1 抑制剂的选择性敏感性。

Solomon, Hilla; Mukherjee, Radha; Yang, Yu Chi; Meredith, Julia; Schram, Alison M; Yi, Sang Ah; Chen, Xiaoping; Tribuzio, Michael; Gundlapalli, Harika; Meyerowitz, Justin; de Stanchina, Elisa; Weigelt, Britta; An, Heeseon; Barry, Simon T; Smith, Jacqueline A M; Singh, Mallika; Rosen, Neal

Paper-Based Vertical Flow Assays for in Vitro Diagnostics and Environmental Monitoring

用于体外诊断和环境监测的纸基垂直流动检测

Jeon, Jaehyung; Choi, Heeseon; Han, Gyeo-Re; Ghosh, Rajesh; Palanisamy, Barath; Di Carlo, Dino; Ozcan, Aydogan; Park, Sungsu

Transforming Porous Membranes into Dual-Gradient Janus Structures by Directional Asymmetric Modification

通过定向不对称改性将多孔膜转化为双梯度 Janus 结构

Jeon, Jaehyung; Choi, Heeseon; Bae, Jinseung; Seo, Gwang Myeong; Han, Jeonghun; Park, Hogyun; Park, Sungsu

Transcriptome profiling of aged-mice ovaries administered with individual ingredients of Samul-tang.

对服用四物汤各成分的老年小鼠卵巢进行转录组分析

Shin Hyejin, Kim Jihyun, Park Musun, Jo Heeseon, Lee Myunggyo, Cha Seongwon, Lee Haeseung, You Sooseong

mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase.

mTORC1 通过 CTLH-WDR26 E3 连接酶控制 UCK2 的周转来调节嘧啶补救途径

Pham Brittany Q, Yi Sang Ah, Ordureau Alban, An Heeseon

Therapeutic potential of ginsenosides in circadian rhythm-based skin disorders

人参皂苷在昼夜节律相关皮肤疾病中的治疗潜力

Ha, Heejun; Shin, Heeseon; Min, Sukhyun; Sutopo, Natasha Christabella; Yerkesh, Khamit; Jung, Eunsun; Song, Minkyung; Cho, Jae Youl; Lee, Jongsung

Activity-based probes and chemical proteomics uncover the biological impact of targeting HMG-CoA Synthase 1 in the mevalonate pathway

基于活性的探针和化学蛋白质组学揭示了靶向甲羟戊酸途径中HMG-CoA合成酶1的生物学影响。

Yi, Sang Ah; Sun, Liang; Rao, Yi; Ordureau, Alban; Lewis, Jason S; An, Heeseon

Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells

正交IMiD-降解子对诱导细胞内选择性蛋白质降解

Brennan, Patrick J; Saunders, Rebecca E; Spanou, Mary; Singleton, Sarah E; Serafini, Marta; Sun, Liang; Heger, Guillaume P; Konopacka, Agnieszka; Beveridge, Ryan D; Taylor, C Cameron; DePaola, Peter 4th; Gordon, Laurie; Bunally, Shenaz B; Saudemont, Aurore; Benowitz, Andrew B; Martinez-Fleites, Carlos; Schmitt, Danielle L; Damoiseaux, Robert; Queisser, Markus A; An, Heeseon; Deane, Charlotte M; Hann, Michael M; Brayshaw, Lewis L; Conway, Stuart J

mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway.

mTORC1-CTLH E3 连接酶通过 Pro/N-降解途径调节 HMG-CoA 合成酶 1 的降解

Yi Sang Ah, Sepic Sara, Schulman Brenda A, Ordureau Alban, An Heeseon

Injectable Biomimetic Hydrogel Constructs for Cell-Based Menopausal Hormone Therapy with Reduced Breast Cancer Potential

可注射仿生水凝胶结构可用于基于细胞的更年期激素治疗,降低乳腺癌风险

Chungmo Yang, Heeseon Yang, Hyerim Kim, Nanum Chung, Jungwoo Shin, Hyewon Min, Kangwon Lee, Jung Ryeol Lee