Heffeter相关文献与解析，生知库 | 链接生命科学的每一步

Federa, Anja; Pitek, Rastislav; Dömötör, Orsolya; Enyedy, Éva A; Terenzi, Alessio; Caban, Monika; Stefanelli, Alessia; D'Anna, Luisa; White, Faye; Heffeter, Petra; Kowol, Christian R

EGFR

肿瘤

EGF

肿瘤免疫

发表日期：2026

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Structure-Activity Relationships of Silver(I)- and Gold(I)-NHC Complexes Reveal Distinctly Different Responses of Cisplatin-Resistant Ovarian Cancer to Bis-NHC-Gold(I) Derivatives

银(I)-和金(I)-NHC配合物的构效关系揭示了顺铂耐药卵巢癌对双-NHC-金(I)衍生物的截然不同的反应

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.5c02355

Bormio Nunes, Julia H; Hacker, Christina; Caban, Monika; Valcanover, Daniel; Yassemipour, Patrick A; Türck, Sebastian; Ott, Ingo; Skos, Lukas; Bileck, Andrea; Gerner, Christopher; Meier-Menches, Samuel M; Mohr, Thomas; Berger, Walter; Kowol, Christian R; Heffeter, Petra

Naphthoquinone-derived tridentate Ru(II) and Os(II) organometallics with exceptional cytotoxicity: synthesis, characterization, stability in aqueous solution and biological in vitro evaluation

萘醌衍生的三齿Ru(II)和Os(II)有机金属化合物具有优异的细胞毒性：合成、表征、水溶液稳定性及体外生物学评价

期刊:Dalton Transactions

影响因子:3.3

doi:10.1039/d5dt01649e

Rosner, Alexander; Geisler, Heiko; Hejl, Michaela; Gradl, Mathias; Legin, Anton A; Prado-Roller, Alexander; Jakupec, Michael A; Heffeter, Petra; Berger, Walter; Keppler, Bernhard K; Kandioller, Wolfgang

When Metal Complexes Evolve, and a Minor Species is the Most Active: the Case of Bis(Phenanthroline)Copper in the Catalysis of Glutathione Oxidation and Hydroxyl Radical Generation

当金属络合物演化时，一种次要物种活性最高：以双(菲咯啉)铜催化谷胱甘肽氧化和羟基自由基生成为例

期刊:Angewandte Chemie-International Edition

影响因子:16.9

doi:10.1002/anie.202414652

Falcone, Enrico; Vigna, Vincenzo; Schueffl, Hemma; Stellato, Francesco; Vileno, Bertrand; Bouraguba, Merwan; Mazzone, Gloria; Proux, Olivier; Morante, Silvia; Heffeter, Petra; Sicilia, Emilia; Faller, Peter

发表日期：2025

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Selectivity for TP53 signalling drives the mode of action of a highly potent N,O,O-tridentate naphthoquinone-based organo-ruthenium anticancer drug candidate

一种高效的基于N,O,O-三齿萘醌的有机钌抗癌候选药物的作用机制取决于其对TP53信号通路的选择性。

期刊:Chemical Science

影响因子:7.4

doi:10.1039/d5sc00735f

Rosner, Alexander; Skos, Lukas; Mendrina, Theresa; Baier, Dina; Hejl, Michaela; Borutzki, Yasmin; Gradl, Mathias; Geisler, Heiko; Mohr, Thomas; Legin, Anton; Jakupec, Michael A; Bileck, Andrea; Gerner, Christopher; Koellensperger, Gunda; Heffeter, Petra; Berger, Walter; Keppler, Bernhard K; Kandioller, Wolfgang; Meier-Menches, Samuel M

Site-Selectively Functionalized Albumin with DFO*Maleimide for (89)Zr-Radiolabeling Yields a Metabolically Stable PET Probe that Enables Late Time-Point Tumor Imaging in Mice.

用 DFO*马来酰亚胺对白蛋白进行位点选择性功能化，用于 (89)Zr 放射性标记，可产生代谢稳定的 PET 探针，从而实现小鼠的晚期肿瘤成像

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.5c00803

Kronberger Julia, Balber Theresa, Schueffl Hemma, Wahrmann Raphaela, Federa Anja, Gradl Mathias, Brandt Marie R, Wanek Thomas, Mitterhauser Markus, Kowol Christian R, Mindt Thomas L, Heffeter Petra

A new fluorescent oxaliplatin(iv) complex with EGFR-inhibiting properties for the treatment of drug-resistant cancer cells

一种新型荧光奥沙利铂(IV)复合物，具有EGFR抑制特性，可用于治疗耐药癌细胞。

期刊:Inorganic Chemistry Frontiers

影响因子:6.4

doi:10.1039/d4qi03025g

Caban, Monika; Fronik, Philipp; Terenzi, Alessio; Federa, Anja; Bormio Nunes, Julia H; Pitek, Rastislav; Kirchhofer, Dominik; Schueffl, Hemma H; Berger, Walter; Keppler, Bernhard K; Kowol, Christian R; Heffeter, Petra

Structural variations in the trans-carboxylate/chlorido axis that impact the mode of action of Pt(ii) complexes

反式羧酸根/氯根轴的结构变化会影响Pt(ii)配合物的作用方式

期刊:Inorganic Chemistry Frontiers

影响因子:6.4

doi:10.1039/d5qi00674k

Fabra, David; Mendrina, Theresa; Matesanz, Ana I; Medrano, Ángeles; Pitek, Rastislav; Poetsch, Isabella; Berger, Walter; Heffeter, Petra; Quiroga, Adoración G

发表日期：2025

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Albumin-targeted oxaliplatin(iv) prodrugs bearing STING agonists

靶向白蛋白的奥沙利铂(IV)前药，带有STING激动剂

期刊:

影响因子:6.1

doi:PMC11969438

Martijn Dijkstra，Michael Gutmann，Mathias Gradl，Anja Federa，Carola Jaunecker，John Vasco Breitenstein，Petra Vician，Christine Pirker，Daniel Valcanover，Petra Heffeter，Bernhard K Keppler，Walter Berger，Christian R Kowol

STING

发表日期：2025

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Albumin-targeted oxaliplatin(iv) prodrugs bearing STING agonists

靶向白蛋白的奥沙利铂(IV)前药，带有STING激动剂

期刊:Inorganic Chemistry Frontiers

影响因子:6.1

doi:10.1039/d5qi00433k

Martijn Dijkstra ，Michael Gutmann ，Mathias Gradl ，Anja Federa ，Carola Jaunecker ，John Vasco Breitenstein ，Petra Vician ，Christine Pirker ，Daniel Valcanover ，Petra Heffeter ，Bernhard K Keppler ，Walter Berger ，Christian R Kowol

STING

发表日期：2025

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Tumor-Targeted Delivery of an EGFR Inhibitor Prodrug via Site-Specific Albumin Conjugation

通过位点特异性白蛋白偶联将 EGFR 抑制剂前药靶向递送至肿瘤部位

Structure-Activity Relationships of Silver(I)- and Gold(I)-NHC Complexes Reveal Distinctly Different Responses of Cisplatin-Resistant Ovarian Cancer to Bis-NHC-Gold(I) Derivatives

银(I)-和金(I)-NHC配合物的构效关系揭示了顺铂耐药卵巢癌对双-NHC-金(I)衍生物的截然不同的反应

Naphthoquinone-derived tridentate Ru(II) and Os(II) organometallics with exceptional cytotoxicity: synthesis, characterization, stability in aqueous solution and biological in vitro evaluation

萘醌衍生的三齿Ru(II)和Os(II)有机金属化合物具有优异的细胞毒性：合成、表征、水溶液稳定性及体外生物学评价

When Metal Complexes Evolve, and a Minor Species is the Most Active: the Case of Bis(Phenanthroline)Copper in the Catalysis of Glutathione Oxidation and Hydroxyl Radical Generation

当金属络合物演化时，一种次要物种活性最高：以双(菲咯啉)铜催化谷胱甘肽氧化和羟基自由基生成为例

Selectivity for TP53 signalling drives the mode of action of a highly potent N,O,O-tridentate naphthoquinone-based organo-ruthenium anticancer drug candidate

一种高效的基于N,O,O-三齿萘醌的有机钌抗癌候选药物的作用机制取决于其对TP53信号通路的选择性。

Site-Selectively Functionalized Albumin with DFO*Maleimide for (89)Zr-Radiolabeling Yields a Metabolically Stable PET Probe that Enables Late Time-Point Tumor Imaging in Mice.

用 DFO*马来酰亚胺对白蛋白进行位点选择性功能化，用于 (89)Zr 放射性标记，可产生代谢稳定的 PET 探针，从而实现小鼠的晚期肿瘤成像

A new fluorescent oxaliplatin(iv) complex with EGFR-inhibiting properties for the treatment of drug-resistant cancer cells

一种新型荧光奥沙利铂(IV)复合物，具有EGFR抑制特性，可用于治疗耐药癌细胞。

Structural variations in the trans-carboxylate/chlorido axis that impact the mode of action of Pt(ii) complexes

反式羧酸根/氯根轴的结构变化会影响Pt(ii)配合物的作用方式

Albumin-targeted oxaliplatin(iv) prodrugs bearing STING agonists

靶向白蛋白的奥沙利铂(IV)前药，带有STING激动剂

Albumin-targeted oxaliplatin(iv) prodrugs bearing STING agonists

靶向白蛋白的奥沙利铂(IV)前药，带有STING激动剂