日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fancl-mutant mice reveal central role of monoubiquitination in Fanconi anemia and a model for therapeutic gene editing

Fancl突变小鼠揭示了单泛素化在范可尼贫血症中的核心作用,并为治疗性基因编辑提供了一种模型。

Liu, Lu; Glaser, Astrid; Isiaku, Abdulsalam I; Fairfax, Kirsten; Casolari, Debora A; Ristovski, Angelina; Murphy, Vincent; van Twest, Sylvie; Henrikus, Sarah S; Heraud-Farlow, Jacki; Granger, Elissah; Novakovic, Stevan; Monks O'Byrne, Sophie F; Tsui, Vanessa; Conyers, Rachel; Gonda, Thomas J; Crismani, Wayne; D'Andrea, Richard J; Heierhorst, Jörg; Deans, Andrew J

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replication

极少量缺乏解旋酶活性的截短型RECQL4足以进行DNA复制。

Buco, Paula Armina V; Castillo-Tandazo, Wilson; Chalk, Alistair M; Pilcher, Courtney; Holien, Jessica K; Heierhorst, Jörg; Tan, Tiong Y; Koren, Amnon; Smeets, Monique F; Walkley, Carl R

Fancm has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals

Fancm 在限制哺乳动物减数分裂交叉和生殖细胞维持方面具有双重作用

Vanessa Tsui, Ruqian Lyu, Stevan Novakovic, Jessica M Stringer, Jessica E M Dunleavy, Elissah Granger, Tim Semple, Anna Leichter, Luciano G Martelotto, D Jo Merriner, Ruijie Liu, Lucy McNeill, Nadeen Zerafa, Eva R Hoffmann, Moira K O'Bryan, Karla Hutt, Andrew J Deans, Jörg Heierhorst, Davis J McCart

The ASCIZ-DYNLL1 Axis Is Essential for TLR4-Mediated Antibody Responses and NF-κB Pathway Activation

ASCIZ-DYNLL1轴对于TLR4介导的抗体反应和NF-κB通路激活至关重要

Rui Liu ,Ashleigh King ,David Tarlinton ,Jörg Heierhorst

Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar dynein function in primary cilia

Dynll1 对发育至关重要,并通过调节初级纤毛中的鞭毛内动力蛋白功能来促进软骨内骨形成

Ashleigh King, Nicolas C Hoch, Narelle E McGregor, Natalie A Sims, Ian M Smyth, Jörg Heierhorst

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4

ATP 依赖性解旋酶活性对于 Recql4 的生理功能而言是可有可无的

Wilson Castillo-Tandazo, Monique F Smeets, Vincent Murphy, Rui Liu, Charlotte Hodson, Jörg Heierhorst, Andrew J Deans, Carl R Walkley

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

ASCIZ-DYNLL1 轴促进 53BP1 依赖的非同源末端连接和 PARP 抑制剂敏感性

Jordan R Becker, Raquel Cuella-Martin, Marco Barazas, Rui Liu, Catarina Oliveira, Antony W Oliver, Kirstin Bilham, Abbey B Holt, Andrew N Blackford, Jörg Heierhorst, Jos Jonkers, Sven Rottenberg, J Ross Chapman

Multivalency regulates activity in an intrinsically disordered transcription factor

多价性调节内在无序转录因子的活性

Sarah Clark, Janette B Myers, Ashleigh King, Radovan Fiala, Jiri Novacek, Grant Pearce, Jörg Heierhorst, Steve L Reichow, Elisar J Barbar

Multivalency regulates activity in an intrinsically disordered transcription factor

多价性调控固有无序转录因子的活性

Clark, Sarah; Myers, Janette B; King, Ashleigh; Fiala, Radovan; Novacek, Jiri; Pearce, Grant; Heierhorst, Jörg; Reichow, Steve L; Barbar, Elisar J

Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner

促凋亡蛋白BIM通过以细胞自主的方式限制成熟B细胞的存活,从而影响B淋巴细胞稳态。

Rui Liu ,Ashleigh King ,Philippe Bouillet ,David M Tarlinton ,Andreas Strasser ,Jörg Heierhorst