Heike Keilhack相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Selective Pharmaceutical Inhibition of PARP14 Mitigates Allergen-Induced IgE and Mucus Overproduction in a Mouse Model of Pulmonary Allergic Response

选择性药物抑制 PARP14 可减轻小鼠肺部过敏反应模型中过敏原诱导的 IgE 和粘液过量产生

期刊:Immunohorizons

doi:10.4049/immunohorizons.2100107

Alex M Eddie, Kevin W Chen, Laurie B Schenkel, Kerren K Swinger, Jennifer R Molina, Kaiko Kunii, Ariel L Raybuck, Heike Keilhack, Katherine N Gibson-Corley, Mario Niepel, R Stokes Peebles, Mark R Boothby, Sung Hoon Cho

发表日期：2022

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Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models

通过抑制 EZH2 选择性杀死 SMARCA2 和 SMARCA4 缺陷型卵巢小细胞癌、高钙血症型细胞：体外和体内临床前模型

期刊:Molecular Cancer Therapeutics

影响因子:5.3

doi:10.1158/1535-7163.MCT-16-0678

Elayne Chan-Penebre, Kelli Armstrong, Allison Drew, Alexandra R Grassian, Igor Feldman, Sarah K Knutson, Kristy Kuplast-Barr, Maria Roche, John Campbell, Peter Ho, Robert A Copeland, Richard Chesworth, Jesse J Smith, Heike Keilhack, Scott A Ribich

发表日期：2017

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EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL

他泽司他抑制 EZH2 导致 DLBCL 对 B 细胞活化信号的依赖性改变

期刊:Molecular Cancer Therapeutics

影响因子:5.3

doi:10.1158/1535-7163.MCT-16-0840

Dorothy Brach, Danielle Johnston-Blackwell, Allison Drew, Trupti Lingaraj, Vinny Motwani, Natalie M Warholic, Igor Feldman, Christopher Plescia, Jesse J Smith, Robert A Copeland, Heike Keilhack, Elayne Chan-Penebre, Sarah K Knutson, Scott A Ribich, Alejandra Raimondi, Michael J Thomenius

细胞生物学

发表日期：2017

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Initial testing (stage 1) of tazemetostat (EPZ-6438), a novel EZH2 inhibitor, by the Pediatric Preclinical Testing Program

儿科临床前测试计划对新型 EZH2 抑制剂他泽司他 (EPZ-6438) 进行初步测试（第 1 阶段）

期刊:Pediatric Blood & Cancer

影响因子:2.4

doi:10.1002/pbc.26218

Raushan T Kurmasheva, Melissa Sammons, Edward Favours, Jianwrong Wu, Dias Kurmashev, Katherine Cosmopoulos, Heike Keilhack, Christine R Klaus, Peter J Houghton, Malcolm A Smith

发表日期：2017

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Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma

EZH2 抑制在人类滑膜肉瘤模型中诱导抗肿瘤活性的临床前证据

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0158888

Satoshi Kawano, Alexandra R Grassian, Masumi Tsuda, Sarah K Knutson, Natalie M Warholic, Galina Kuznetsov, Shanqin Xu, Yonghong Xiao, Roy M Pollock, Jesse S Smith, Kevin K Kuntz, Scott Ribich, Yukinori Minoshima, Junji Matsui, Robert A Copeland, Shinya Tanaka, Heike Keilhack

发表日期：2016

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Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas

EZH2 抑制剂和糖皮质激素受体激动剂在生发中心非霍奇金淋巴瘤模型中的协同抗肿瘤活性

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0111840

Sarah K Knutson, Natalie M Warholic, L Danielle Johnston, Christine R Klaus, Tim J Wigle, Dorothy Iwanowicz, Bruce A Littlefield, Margaret Porter-Scott, Jesse J Smith, Mikel P Moyer, Robert A Copeland, Roy M Pollock, Kevin W Kuntz, Alejandra Raimondi, Heike Keilhack

发表日期：2014

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Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

通过抑制甲基转移酶 EZH2 实现基因改变的恶性横纹肌样瘤的持久肿瘤消退

期刊:Proceedings of the National Academy of Sciences of the United States of America

doi:10.1073/pnas.1303800110

Sarah K Knutson, Natalie M Warholic, Tim J Wigle, Christine R Klaus, Christina J Allain, Alejandra Raimondi, Margaret Porter Scott, Richard Chesworth, Mikel P Moyer, Robert A Copeland, Victoria M Richon, Roy M Pollock, Kevin W Kuntz, Heike Keilhack

发表日期：2013

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Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors

mTOR 通过 AKT 非依赖性机制激活的证据为使用 mTOR 和 AKT 抑制剂联合治疗 PTEN 缺陷型前列腺肿瘤提供了支持

期刊:Translational Oncology

影响因子:4.5

doi:10.1593/tlo.12241

Weisheng Zhang, Brian B Haines, Clay Efferson, Joe Zhu, Chris Ware, Kaiko Kunii, Jennifer Tammam, Minilik Angagaw, Marlene C Hinton, Heike Keilhack, Cloud P Paweletz, Theresa Zhang, Chris Winter, Sriram Sathyanarayanan, Jonathan Cheng, Leigh Zawel, Stephen Fawell, Gary Gilliland, Pradip K Majumder

发表日期：2012

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Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor

癌细胞中 PDK1 的基因和药理抑制：选择性变构激酶抑制剂的表征

期刊:Journal of Biological Chemistry

doi:10.1074/jbc.M110.156463

Kumiko Nagashima, Stuart D Shumway, Sriram Sathyanarayanan, Albert H Chen, Brian Dolinski, Youyuan Xu, Heike Keilhack, Thi Nguyen, Maciej Wiznerowicz, Lixia Li, Bart A Lutterbach, An Chi, Cloud Paweletz, Timothy Allison, Youwei Yan, Sanjeev K Munshi, Anke Klippel, Manfred Kraus, Ekaterina V Bobkova,

细胞生物学

发表日期：2011

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