日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

一项针对122341名欧洲血统患者的主要焦虑症的全基因组关联研究,发现了58个基因位点,并强调了GABA能信号传导的作用。

Strom, Nora I; Verhulst, Brad; Bacanu, Silviu-Alin; Cheesman, Rosa; Purves, Kirstin L; Gedik, Hüseyin; Mitchell, Brittany L; Kwong, Alex S; Faucon, Annika B; Singh, Kritika; Medland, Sarah; Colodro-Conde, Lucia; Krebs, Kristi; Hoffmann, Per; Herms, Stefan; Gehlen, Jan; Ripke, Stephan; Awasthi, Swapnil; Palviainen, Teemu; Tasanko, Elisa M; Peterson, Roseann E; Adkins, Daniel E; Shabalin, Andrey A; Adams, Mark J; Iveson, Matthew H; Campbell, Archie; Thomas, Laurent F; Winsvold, Bendik S; Drange, Ole Kristian; Børte, Sigrid; Ter Kuile, Abigail R; Naamanka, Joonas; Nguyen, Tan-Hoang; Meier, Sandra M; Corfield, Elizabeth C; Hannigan, Laurie; Levey, Daniel F; Czamara, Darina; Weber, Heike; Choi, Karmel W; Pistis, Giorgio; Couvy-Duchesne, Baptiste; Van der Auwera, Sandra; Teumer, Alexander; Karlsson, Robert; Garcia-Argibay, Miguel; Lee, Donghyung; Wang, Rujia; Bjerkeset, Ottar; Stordal, Eystein; Bäckman, Julia; Salum, Giovanni A; Zai, Clement C; Kennedy, James L; Zai, Gwyneth; Tiwari, Arun K; Heilmann-Heimbach, Stefanie; Schmidt, Börge; Kaprio, Jaakko; Kennedy, Martin M; Boden, Joseph; Havdahl, Alexandra; Middeldorp, Christel M; Lopes, Fabiana L; Akula, Nirmala; McMahon, Francis J; Binder, Elisabeth B; Fehm, Lydia; Ströhle, Andreas; Castelao, Enrique; Tiemeier, Henning; Stein, Dan J; Whiteman, David; Olsen, Catherine; Fuller, Zachary; Wang, Xin; Wray, Naomi R; Byrne, Enda M; Lewis, Glyn; Timpson, Nicholas J; Davis, Lea K; Hickie, Ian B; Gillespie, Nathan A; Milani, Lili; Schumacher, Johannes; Woldbye, David P; Forstner, Andreas J; Nöthen, Markus M; Hovatta, Iiris; Horwood, John; Copeland, William E; Maes, Hermine H; McIntosh, Andrew M; Andreassen, Ole A; Zwart, John-Anker; Mors, Ole; Børglum, Anders D; Mortensen, Preben B; Ask, Helga; Reichborn-Kjennerud, Ted; Najman, Jackob M; Stein, Murray B; Gelernter, Joel; Milaneschi, Yuri; Penninx, Brenda W; Boomsma, Dorret I; Maron, Eduard; Erhardt-Lehmann, Angelika; Rück, Christian; Kircher, Tilo T; Melzig, Christiane A; Alpers, Georg W; Arolt, Volker; Domschke, Katharina; Smoller, Jordan W; Preisig, Martin; Martin, Nicholas G; Lupton, Michelle K; Luik, Annemarie I; Reif, Andreas; Grabe, Hans J; Larsson, Henrik; Magnusson, Patrik K; Oldehinkel, Albertine J; Hartman, Catharina A; Breen, Gerome; Docherty, Anna R; Coon, Hilary; Conrad, Rupert; Lehto, Kelli; Deckert, Jürgen; Eley, Thalia C; Mattheisen, Manuel; Hettema, John M

Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

欧洲人群阿尔茨海默病多基因风险评分在不同族裔人群中的适用性

Nicolas, Aude; Sherva, Richard; Grenier-Boley, Benjamin; Kim, Yoontae; Kikuchi, Masataka; Timsina, Jigyasha; de Rojas, Itziar; Dalmasso, María Carolina; Zhou, Xiaopu; Le Guen, Yann; Arboleda-Bustos, Carlos E; Camargos Bicalho, Maria Aparecida; Guerchet, Maëlenn; van der Lee, Sven; Goss, Monica; Castillo, Atahualpa; Bellenguez, Céline; Küçükali, Fahri; Satizabal, Claudia L; Fongang, Bernard; Yang, Qiong; Peters, Oliver; Schneider, Anja; Dichgans, Martin; Rujescu, Dan; Scherbaum, Norbert; Deckert, Jürgen; Riedel-Heller, Steffi; Hausner, Lucrezia; Molina-Porcel, Laura; Düzel, Emrah; Grimmer, Timo; Wiltfang, Jens; Heilmann-Heimbach, Stefanie; Moebus, Susanne; Tegos, Thomas; Scarmeas, Nikolaos; Dols-Icardo, Oriol; Moreno, Fermin; Pérez-Tur, Jordi; Bullido, María J; Pastor, Pau; Sánchez-Valle, Raquel; Álvarez, Victoria; Cao, Han; Ip, Nancy Y; Fu, Amy K Y; Ip, Fanny C F; Olivar, Natividad; Muchnik, Carolina; Cuesta, Carolina; Campanelli, Lorenzo; Solis, Patricia; Politis, Daniel Gustavo; Kochen, Silvia; Brusco, Luis Ignacio; Boada, Mercè; García-González, Pablo; Puerta, Raquel; Mir, Pablo; Real, Luis M; Piñol-Ripoll, Gerard; García-Alberca, Jose María; Royo, Jose Luís; Rodriguez-Rodriguez, Eloy; Soininen, Hilkka; Heikkinen, Sami; de Mendonça, Alexandre; Mehrabian, Shima; Traykov, Latchezar; Hort, Jakub; Vyhnalek, Martin; Rasmussen, Katrine Laura; Thomassen, Jesper Qvist; Pijnenburg, Yolande A L; Holstege, Henne; van Swieten, John C; Seelaar, Harro; Claassen, Jurgen A H R; Jansen, Willemijn J; Ramakers, Inez; Verhey, Frans; van der Lugt, Aad; Scheltens, Philip; Ortega-Rojas, Jenny; Concha Mera, Ana Gabriela; Mahecha, Maria F; Pardo, Rodrigo; Arboleda, Gonzalo; Bahrami, Shahram; Fominykh, Vera; Selbæk, Geir; Graff, Caroline; Papenberg, Goran; Giedraitis, Vilmantas; Boland, Anne; Deleuze, Jean-François; de Marco, Luiz Armando; de Moraes, Edgar Nunes; de Mattos Viana, Bernardo; Túlio Gualberto Cintra, Marco; Juarez-Cedillo, Teresa; Griswold, Anthony J; Forund, Tatiana; Haines, Jonathan; Farrer, Lindsay; DeStefano, Anita; Wijsman, Ellen; Mayeux, Richard; Pericak-Vance, Margaret; Kunkle, Brian; Goate, Alison; Schellenberg, Gerard D; Vardarajan, Badri; Wang, Li-San; Leung, Yuk Yee; Dalgard, Clifton L; Nicolas, Gael; Wallon, David; Dufouil, Carole; Pasquier, Florence; Hanon, Olivier; Debette, Stéphanie; Grünblatt, Edna; Popp, Julius; Angel, Bárbara; Gloger, Sergio; Chacon, Maria Victoria; Aranguiz, Rafael; Orellana, Paulina; Slachevsky, Andrea; Gonzalez-Billault, Christian; Albala, Cecilia; Fuentes, Patricio; Sachdev, Perminder; Mather, Karen A; Hauger, Richard L; Merritt, Victoria; Panizzon, Matthew; Zhang, Rui; Gaziano, J Michael; Ghidoni, Roberta; Galimberti, Daniela; Arosio, Beatrice; Mecocci, Patrizia; Solfrizzi, Vincenzo; Parnetti, Lucilla; Squassina, Alessio; Tremolizzo, Lucio; Borroni, Barbara; Nacmias, Benedetta; Caffarra, Paolo; Seripa, Davide; Rainero, Innocenzo; Daniele, Antonio; Piras, Fabrizio; Leonard, Hampton L; Yokoyama, Jenifer S; Nalls, Mike A; Miyashita, Akinori; Hara, Norikazu; Ozaki, Kouichi; Niida, Shumpei; Williams, Julie; Masullo, Carlo; Amouyel, Philippe; Preux, Pierre-Marie; Mbelesso, Pascal; Bandzouzi, Bébène; Saykin, Andy; Jessen, Frank; Kehoe, Patrick G; Van Duijn, Cornelia; Ben Salem, Nesrine; Frikke-Schmidt, Ruth; Cherni, Lotfi; Greicius, Michael D; Tsolaki, Magda; Sánchez-Juan, Pascual; Romano Silva, Marco Aurélio; Porter, Tenielle; Laws, Simon M; Sleegers, Kristel; Ingelsson, Martin; Dartigues, Jean-François; Seshadri, Sudha; Rossi, Giacomina; Morelli, Laura; Hiltunen, Mikko; Sims, Rebecca; van der Flier, Wiesje; Andreassen, Ole A; Arboleda, Humberto; Cruchaga, Carlos; Escott-Price, Valentina; Ruiz, Agustín; Lee, Kun Ho; Ikeuchi, Takeshi; Ramirez, Alfredo; Gim, Jungsoo; Logue, Mark; Lambert, Jean-Charles

First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia

首个全基因组关联研究揭示特发性贲门失弛症的免疫介导病因

Grover, Sandeep; Gockel, Ines; Latiano, Anna; Mokrowiecka, Anna; Dasmeh, Pouria; Wouters, Mira M; Vackova, Zuzana; Haas, Stephan L; Triantafyllou, Tania; Kreuser, Nicole; Trautmann, Jessica; Niebisch, Stefan; Hess, Timo; Thieme, Rene; Bigge, Jessica; Louis, Hubert; Quertinmont, Eric; Meirhaeghe, Aline; Muntaner, Manon; Amouyel, Philippe; Gourcerol, Guillaume; Bruley des Varannes, Stanislas; Mion, Francois; Vieth, Michael; Scarmeas, Nikolaos; Palmieri, Orazio; Tavano, Francesca; De Giorgio, Roberto; Galimberti, Daniela; Arighi, Andrea; Arosio, Beatrice; Bruno, Marco; Wasielica-Berger, Justyna; Gawron-Kiszka, Magdalena; Janiak, Maria; Siepsiak, Magdalena; Adrych, Krystian; Marek, Tomasz; Dabrowski, Andrzej; Majewski, Marek; Gietka, Piotr; Gonciarz, Maciej; Pérez de la Serna, Julio; Martínez, Laisy Zacarías; Giedraitis, Vilmantas; Kilander, Lena; Fratiglioni, Laura; Real, Luis Miguel; Spicak, Julius; Tack, Jan; Heilmann-Heimbach, Stefanie; Nöthen, Markus; Ingelsson, Martin; Graff, Caroline; Ruiz, Agustín; Lambert, Jean-Charles; Ramirez, Alfredo; Eckardt, Alexander J; Müller, Michaela; Knapp, Michael; Wissinowski, Thaddäus T; Keller, Jutta; Bruns, Christiane Josephine; Gerges, Christian; Neuhaus, Horst; Rösch, Thomas; Siegmund, Britta; Schumacher, Brigitte; Venerito, Marino; Ruiz de León, Antonio; Rosati, Riccardo; Annese, Vito; Fumagalli, Uberto; Laghi, Luigi; Urcelay, Elena; Vavasseur, Fabienne; Roman, Sabine; Zhou, Pinghong; Li, Quanlin; Liu, Zuqiang; Rahden, Burkhard H A von; Theodorou, Dimitris; Malecka-Wojciesko, Ewa; Maj, Carlo; Vigo, Ana G; Martinek, Jan; Boeckxstaens, Guy; Schumacher, Johannes

Machine learning in Alzheimer's disease genetics

机器学习在阿尔茨海默病遗传学中的应用

Bracher-Smith, Matthew; Melograna, Federico; Ulm, Brittany; Bellenguez, Céline; Grenier-Boley, Benjamin; Duroux, Diane; Nevado, Alejo J; Holmans, Peter; Tijms, Betty M; Hulsman, Marc; de Rojas, Itziar; Campos-Martin, Rafael; der Lee, Sven van; Castillo, Atahualpa; Küçükali, Fahri; Peters, Oliver; Schneider, Anja; Dichgans, Martin; Rujescu, Dan; Scherbaum, Norbert; Deckert, Jürgen; Riedel-Heller, Steffi; Hausner, Lucrezia; Molina-Porcel, Laura; Düzel, Emrah; Grimmer, Timo; Wiltfang, Jens; Heilmann-Heimbach, Stefanie; Moebus, Susanne; Tegos, Thomas; Scarmeas, Nikolaos; Dols-Icardo, Oriol; Moreno, Fermin; Pérez-Tur, Jordi; Bullido, María J; Pastor, Pau; Sánchez-Valle, Raquel; Álvarez, Victoria; Boada, Mercè; García-González, Pablo; Puerta, Raquel; Mir, Pablo; Real, Luis M; Piñol-Ripoll, Gerard; García-Alberca, Jose María; Rodriguez-Rodriguez, Eloy; Soininen, Hilkka; Heikkinen, Sami; de Mendonça, Alexandre; Mehrabian, Shima; Traykov, Latchezar; Hort, Jakub; Vyhnalek, Martin; Sandau, Nicolai; Thomassen, Jesper Qvist; Pijnenburg, Yolande A L; Holstege, Henne; van Swieten, John; Ramakers, Inez; Verhey, Frans; Scheltens, Philip; Graff, Caroline; Papenberg, Goran; Giedraitis, Vilmantas; Williams, Julie; Amouyel, Philippe; Boland, Anne; Deleuze, Jean-François; Nicolas, Gael; Dufouil, Carole; Pasquier, Florence; Hanon, Olivier; Debette, Stéphanie; Grünblatt, Edna; Popp, Julius; Ghidoni, Roberta; Galimberti, Daniela; Arosio, Beatrice; Mecocci, Patrizia; Solfrizzi, Vincenzo; Parnetti, Lucilla; Squassina, Alessio; Tremolizzo, Lucio; Borroni, Barbara; Wagner, Michael; Nacmias, Benedetta; Spallazzi, Marco; Seripa, Davide; Rainero, Innocenzo; Daniele, Antonio; Piras, Fabrizio; Masullo, Carlo; Rossi, Giacomina; Jessen, Frank; Kehoe, Patrick; Magda, Tsolaki; Sánchez-Juan, Pascual; Sleegers, Kristel; Ingelsson, Martin; Hiltunen, Mikko; Sims, Rebecca; van der Flier, Wiesje; Andreassen, Ole A; Ruiz, Agustín; Ramirez, Alfredo; Frikke-Schmidt, Ruth; Amin, Najaf; Roshchupkin, Gennady; Lambert, Jean-Charles; Van Steen, Kristel; van Duijn, Cornelia; Escott-Price, Valentina

A meta-analysis of genome-wide studies of resilience in the German population

一项针对德国人群韧性的全基因组研究的荟萃分析

Herrera-Rivero, Marisol; Garvert, Linda; Horn, Katrin; Löbner, Margrit; Weitzel, Elena Caroline; Stoll, Monika; Lichtner, Peter; Teismann, Henning; Teumer, Alexander; Van der Auwera, Sandra; Völzke, Henry; Völker, Uwe; Andlauer, Till F M; Meinert, Susanne; Heilmann-Heimbach, Stefanie; Forstner, Andreas J; Streit, Fabian; Witt, Stephanie H; Kircher, Tilo; Dannlowski, Udo; Scholz, Markus; Riedel-Heller, Steffi G; Grabe, Hans J; Baune, Bernhard T; Berger, Klaus

Implications of monogenic bicuspid aortic valve (BAV) forms among sporadic BAV patients

单基因二叶式主动脉瓣(BAV)在散发性BAV患者中的意义

Bruenger, Christopher M H; Oeffner, Frank; Koebbe, Laura L; Zimmer, Sebastian; Veulemans, Verena; Adam, Matti; Bigge, Jessica; Heilmann-Heimbach, Stefanie; Kelm, Malte; Baldus, Stephan; Nöthen, Markus M; Nickenig, Georg; Maj, Carlo; Al-Kassou, Baravan; Schumacher, Johannes

Assessing the suitability of formalin-fixed paraffin-embedded (FFPE) tissue for genome-wide association studies (GWAS)

评估福尔马林固定石蜡包埋(FFPE)组织对全基因组关联研究(GWAS)的适用性

Reingruber, Julian; Krämer, Maximilian J; Bigge, Jessica; Dasmeh, Pouria; Grover, Sandeep; Heilmann-Heimbach, Stefanie; Nöthen, Markus M; Kreuser, Nicole; Gockel, Ines; Veits, Lothar; Vieth, Michael; Jank, Paul; Denkert, Carsten; Maj, Carlo; Hess, Timo; Schumacher, Johannes

Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer's Disease in European Populations: Development and Validation

用于预测欧洲人群中与年龄相关的阿尔茨海默病风险的多基因风险评分:开发和验证

Akdeniz, Bayram Cevdet; Bahrami, Shahram; Hagen, Espen; Fuhrer, Julian; Fominykh, Vera; Shadrin, Alexey; Filiz, Tahir Tekin; Athanasiu, Lavinia; Grenier-Boley, Benjamin; Bellenguez, Céline; de Rojas, Itziar; Küçükali, Fahri; Schneider, Anja; Kleineidam, Luca; Rujescu, Dan; Scherbaum, Norbert; Deckert, Jürgen; Riedel-Heller, Steffi; Hausner, Lucrezia; Molina-Porcel, Laura; Grimmer, Timo; Heilmann-Heimbach, Stefanie; Moebus, Susanne; Scarmeas, Nikolaos; García-Alberca, Jose María; Franco-Macías, Emilio; Mir, Pablo; Real, Luis M; Rodriguez-Rodriguez, Eloy; Royo, Jose Luís; Sáez, María Eugenia; Carracedo, Ángel; de Munain, Adolfo Lopez; Amer-Ferrer, Guillermo; Calero, Miguel; Medina, Miguel; Garcia-Ribas, Guillermo; Mendioroz, Maite; Dols-Icardo, Oriol; Moreno, Fermin; Pérez-Tur, Jordi; Bullido, María J; Álvarez, Victoria; Soininen, Hilkka; Heikkinen, Sami; de Mendonça, Alexandre; Mehrabian, Shima; Traykov, Latchezar; Hort, Jakub; Vyhnalek, Martin; Sandau, Nicolai; Thomassen, Jesper Qvist; Luo, Jiao; Pijnenburg, Yolande A L; Tesi, Niccolo; van Swieten, John; Giedraitis, Vilmantas; Williams, Julie; Nicolas, Gael; Debette, Stephanie; Amouyel, Philippe; Grünblatt, Edna; Popp, Julius; Bossù, Paola; Galimberti, Daniela; Rossi, Giacomina; Arosio, Beatrice; Mecocci, Patrizia; Squassina, Alessio; Tremolizzo, Lucio; Borroni, Barbara; Nacmias, Benedetta; Seripa, Davide; Rainero, Innocenzo; Daniele, Antonio; Piras, Fabrizio; Masullo, Carlo; Kehoe, Patrick Gavin; Frikke-Schmidt, Ruth; Ghidoni, Roberta; Ruiz, Agustín; Fernandez, Victoria; Sánchez-Juan, Pascual; Sleegers, Kristel; Ingelsson, Martin; Hiltunen, Mikko; Sims, Rebecca; Ramirez, Alfredo; Broce, Iris J; Haavik, Jan; Selbæk, Geir; Knapskog, Anne-Brita; Saltvedt, Ingvild; Bergh, Sverre; Aakhus, Eivind; Kirsebom, Bjørn-Eivind; Watne, Leiv Otto; Rongve, Arvid; Årsland, Dag; Djurovic, Srdjan; Stordal, Eystein; Toft, Mathias; Scheffler, Katja; Fladby, Tormod; Lambert, Jean-Charles; Dale, Anders; Frei, Oleksandr; Andreassen, Ole

Targeting ATR offers multifaceted treatment strategies involving RAD51-mediated compensatory DNA repair in bladder cancer

靶向ATR可为膀胱癌治疗提供多方面的策略,包括RAD51介导的代偿性DNA修复。

Pannhausen, Julia; Chughtai, Ahmed A; Yüce, Cem-Louis; Melzer, Michael K; Ma, Yanchun; Seillier, Lancelot; van der Vorst, Emiel P C; Andrieux, Geoffroy; Wirtz, Julia; Leypold, Sophie; Kühnel, Mark P; Hoffmann, Per; Heilmann-Heimbach, Stefanie; Boerries, Melanie; Kleger, Alexander; Saar, Matthias; Eble, Michael J; Jonigk, Danny D; Gaisa, Nadine T; Rose, Michael

The first genome-wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease

阿根廷和智利人群中首个全基因组关联研究发现,阿尔茨海默病与欧洲人群存在共同的遗传特征。

Dalmasso, Maria Carolina; de Rojas, Itziar; Olivar, Natividad; Muchnik, Carolina; Angel, Bárbara; Gloger, Sergio; Sanchez Abalos, Mariana Soledad; Chacón, María Victoria; Aránguiz, Rafael; Orellana, Paulina; Cuesta, Carolina; Galeano, Pablo; Campanelli, Lorenzo; Novack, Gisela Vanina; Martinez, Luis Eduardo; Medel, Nancy; Lisso, Julieta; Sevillano, Zulma; Irureta, Nicolás; Castaño, Eduardo Miguel; Montrreal, Laura; Thoenes, Michaela; Hanses, Claudia; Heilmann-Heimbach, Stefanie; Kairiyama, Claudia; Mintz, Inés; Villella, Ivana; Rueda, Fabiana; Romero, Amanda; Wukitsevits, Nancy; Quiroga, Ivana; Gona, Cristian; Lambert, Jean-Charles; Solis, Patricia; Politis, Daniel Gustavo; Mangone, Carlos Alberto; Gonzalez-Billault, Christian; Boada, Mercè; Tàrraga, Lluís; Slachevsky, Andrea; Albala, Cecilia; Fuentes, Patricio; Kochen, Silvia; Brusco, Luis Ignacio; Ruiz, Agustín; Morelli, Laura; Ramírez, Alfredo