日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Yeast Display Technology Enables Rapid Discovery of Low-Nanomolar Macrocyclic Peptide Inhibitors of Human Angiotensin-Converting Enzyme 2

酵母展示技术可快速发现低纳摩尔级人血管紧张素转化酶2大环肽抑制剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c02876
Romanyuk, Zhanna; Bettin, Giacomo; Brear, Paul; Linciano, Sara; Mazzocato, Ylenia; Bonadies, Simone; Zanotto, Ilaria; Mazzucco, Camilla; Monferone, Alan; Soler, Miguel A; Pasut, Gianfranco; Martin, Sara De; Scarso, Alessandro; Heinis, Christian; Rothenberger, Sylvia; Hyvönen, Marko; Angelini, Alessandro
Yeast
Human
发表日期：2026
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Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking.

利用酵母展示技术筛选大环肽库可以控制选择过程和亲和力排序

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-60907-x
Linciano Sara, Mazzocato Ylenia, Romanyuk Zhanna, Vascon Filippo, Farrera-Soler Lluc, Will Edward, Xing Yuyu, Chen Shiyu, Kumada Yoichi, Simeoni Marta, Scarso Alessandro, Cendron Laura, Heinis Christian, Angelini Alessandro
其它
Yeast
发表日期：2025
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Ligand-Directed Site-Selective Cysteine Bioconjugation of the KELCH Domain of KEAP1 with Hypervalent Iodine Reagents

利用高价碘试剂对KEAP1的KELCH结构域进行配体导向的位点选择性半胱氨酸生物偶联

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.5c13391
Marty, Christine; Ji, Xinjian; Nicolai, Stefano; Heinis, Christian; Waser, Jerome
KEAP1
KEL
发表日期：2025
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Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11

组蛋白去乙酰化酶11的从头大环抑制剂的发现

期刊:JACS Au
影响因子:8.7
doi:10.1021/jacsau.4c01148
Danková, Daniela; Nielsen, Alexander L; Zarda, Anne; Hansen, Tobias N; Hesse, Marie; Benová, Michaela; Tsiris, Athanasios; Bartling, Christian R O; Will, Edward J; Strømgaard, Kristian; Moreno-Yruela, Carlos; Heinis, Christian; Olsen, Christian A
乙酰化
表观遗传
发表日期：2025
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Cys-Cys and Cys-Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents

高价碘试剂促进未保护肽的Cys-Cys和Cys-Lys交联

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202014511
Ceballos, Javier; Grinhagena, Elija; Sangouard, Gontran; Heinis, Christian; Waser, Jerome
发表日期：2021
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Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs

环肽FXII抑制剂在血栓模型和人工肺中均能提供安全的抗凝血作用。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-020-17648-w
Wilbs, Jonas; Kong, Xu-Dong; Middendorp, Simon J; Prince, Raja; Cooke, Alida; Demarest, Caitlin T; Abdelhafez, Mai M; Roberts, Kalliope; Umei, Nao; Gonschorek, Patrick; Lamers, Christina; Deyle, Kaycie; Rieben, Robert; Cook, Keith E; Angelillo-Scherrer, Anne; Heinis, Christian
心血管
发表日期：2020
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Macrocycle synthesis strategy based on step-wise "adding and reacting" three components enables screening of large combinatorial libraries

基于逐步“添加和反应”三种组分的环大分子合成策略，能够筛选大型组合库。

期刊:Chemical Science
影响因子:7.4
doi:10.1039/d0sc01944e
Mothukuri, Ganesh K; Kale, Sangram S; Stenbratt, Carl L; Zorzi, Alessandro; Vesin, Jonathan; Bortoli Chapalay, Julien; Deyle, Kaycie; Turcatti, Gerardo; Cendron, Laura; Angelini, Alessandro; Heinis, Christian
发表日期：2020
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