日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular basis of ligand binding and receptor activation at the human A(3) adenosine receptor.

人类A(3)腺苷受体配体结合和受体激活的分子基础

Zhang Liudi, Mobbs Jesse I, Bennetts Felix M, Venugopal Hariprasad, Nguyen Anh T N, Christopoulos Arthur, van der Es Daan, Heitman Laura H, May Lauren T, Glukhova Alisa, Thal David M

Absence of Functional Autoantibodies Targeting Angiotensin II Receptor Type 1 and Endothelin-1 Type A Receptor in Circulation and Purified IgG From Patients With Systemic Sclerosis.

系统性硬化症患者循环和纯化 IgG 中不存在针对血管紧张素 II 受体 1 型和内皮素-1 A 型受体的功能性自身抗体

van Oostveen Wieke M, Hoekstra Eva M, Levarht E W Nivine, Kotliar Ilana B, Sakmar Thomas P, Toes René E M, de Vries-Bouwstra Jeska K, Heitman Laura H, Fehres Cynthia M

The endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesicles.

内源性大麻素 2-花生四烯酸甘油酯可按需通过细胞外微囊泡释放和运输

Straub Verena M, Barti Benjamin, Tandar Sebastian T, Stevens A Floor, van Egmond Noëlle, van der Wel Tom, Zhu Na, Rüegger Joel, van der Horst Cas, Heitman Laura H, Li Yulong, Stella Nephi, van Hasselt J G Coen, Katona István, van der Stelt Mario

Leveraging Targeted Protein Degradation for G Protein-Coupled Receptors: The Development of CCR2 Molecular Degraders

利用靶向蛋白降解技术调控G蛋白偶联受体:CCR2分子降解剂的开发

Essa, Khaled; Ortiz Zacarías, Natalia V; Roth, Sascha; Xin, Bo-Tao; de Winter, Sabine; van der Horst, Cas; Bleijs, Bente; de Heiden, Richard A; Voulgaraki, Rodanthi; Neubert, Elsa; Ovaa, Huib; Danen, Erik H J; Mulder, Monique P C; Moreau, Kevin; van der Es, Daan; Heitman, Laura H

Combining AlphaFold with Focused Virtual Library Design in the Development of Novel CCR2 and CCR5 Antagonists

将 AlphaFold 与聚焦虚拟文库设计相结合,用于开发新型 CCR2 和 CCR5 拮抗剂

Essa, Khaled; Noorman van der Dussen, Kian; Yao, Yao; Bleijs, Bente; Ortiz Zacarias, Natalia V; Heitman, Laura H; van Westen, Gerard J P; Jespers, Willem; van der Es, Daan; Šícho, Martin

Toward Assay-Aware Bioactivity Model(er)s: Getting a Grip on Biological Context

迈向基于检测的生物活性模型:把握生物学背景

Schoenmaker, Linde; Sastrokarijo, Enzo G; Heitman, Laura H; Beltman, Joost B; Jespers, Willem; van Westen, Gerard J P

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay.

一种通用的大麻素 CB1 和 CB2 受体 TR-FRET 动力学配体结合测定法

Borrega-Roman Leire, Hoare Bradley L, Kosar Miroslav, Sarott Roman C, Patej Kacper J, Bouma Jara, Scott-Dennis Morgan, Koers Eline J, Gazzi Thais, Mach Leonard, Barrondo Sergio, Sallés Joan, Guba Wolfgang, Kusznir Eric, Nazaré Marc, Rufer Arne C, Grether Uwe, Heitman Laura H, Carreira Erick M, Sykes David A, Veprintsev Dmitry B

Covalent functionalization of G protein-coupled receptors by small molecular probes

利用小分子探针实现G蛋白偶联受体的共价功能化

Beerkens, Bert L H; IJzerman, Adriaan P; Heitman, Laura H; van der Es, Daan

Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools

探索新型地拉泽普衍生物作为hENT1抑制剂和潜在的共价分子工具

Dilweg, Majlen A; Gorostiola González, Marina; de Ruiter, Martijn D; Meijboom, Nadine J; van Veldhoven, Jacobus P D; Liu, Rongfang; Jespers, Willem; van Westen, Gerard J P; Heitman, Laura H; IJzerman, Adriaan P; van der Es, Daan

Computational Characterization of Membrane Proteins as Anticancer Targets: Current Challenges and Opportunities

利用计算方法表征膜蛋白作为抗癌靶点:当前挑战与机遇

Gorostiola González, Marina; Rakers, Pepijn R J; Jespers, Willem; IJzerman, Adriaan P; Heitman, Laura H; van Westen, Gerard J P