日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy

PVTX-405 的开发旨在将其作为一种高效且高选择性的 IKZF2 分子胶降解剂用于癌症免疫治疗。

Zhixiang Chen # ,Harshil Dhruv # ,Xuqing Zhang # ,Rohan Kalyan Rej # ,Longchuan Bai # ,Donna McEachern ,Paul Kirchhoff ,Rakesh Nagilla ,Larry J Jolivette ,Cory T Rice ,Peter Orth ,Corey O Strickland ,E Scott Priestley ,Helai P Mohammad ,Meilin Wang ,Bo Wen ,Duxin Sun ,Zhihua Sui ,Shaomeng Wang

Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell-Mediated Antitumor Immune Responses

抑制I型精氨酸甲基转移酶活性可促进T细胞介导的抗肿瘤免疫反应

Andrew Fedoriw # ,Leilei Shi # ,Shane O'Brien ,Kimberly N Smitheman ,Yunfei Wang ,Jiakai Hou ,Christian Sherk ,Satyajit Rajapurkar ,Jenny Laraio ,Leila J Williams ,Chunyu Xu ,Guangchun Han ,Qin Feng ,Mark T Bedford ,Linghua Wang ,Olena Barbash ,Ryan G Kruger ,Patrick Hwu ,Helai P Mohammad ,Weiyi Peng

Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA-Mutant Colorectal Cancer

赖氨酸特异性去甲基化酶 1 介导 AKT 活性并促进 PIK3CA 突变结直肠癌的上皮-间质转化

Samuel A Miller, Robert A Policastro, Sudha S Savant, Shruthi Sriramkumar, Ning Ding, Xiaoyu Lu, Helai P Mohammad, Sha Cao, Jay H Kalin, Philip A Cole, Gabriel E Zentner, Heather M O'Hagan

Identification of hnRNP-A1 as a pharmacodynamic biomarker of type I PRMT inhibition in blood and tumor tissues

鉴定hnRNP-A1为血液和肿瘤组织中I型PRMT抑制的药效学生物标志物

Paul B Noto ,Timothy W Sikorski ,Francesca Zappacosta ,Craig D Wagner ,Rocio Montes de Oca ,Matthew E Szapacs ,Roland S Annan ,Yan Liu ,Charles F McHugh ,Helai P Mohammad ,Steven P Piccoli ,Caretha L Creasy

Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML

合理靶向表观基因组的协同层可提高 AML 治疗效果

Cihangir Duy, Matt Teater, Francine E Garrett-Bakelman, Tak C Lee, Cem Meydan, Jacob L Glass, Meng Li, Johannes C Hellmuth, Helai P Mohammad, Kimberly N Smitheman, Alan H Shih, Omar Abdel-Wahab, Martin S Tallman, Monica L Guzman, David Muench, H Leighton Grimes, Gail J Roboz, Ryan G Kruger, Caretha

Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis

组蛋白去甲基化酶LSD1是生发中心形成和BCL6驱动的淋巴瘤发生所必需的

Katerina Hatzi ,Huimin Geng ,Ashley S Doane ,Cem Meydan ,Reed LaRiviere ,Mariano Cardenas ,Cihangir Duy ,Hao Shen ,Maria Nieves Calvo Vidal ,Timour Baslan ,Helai P Mohammad ,Ryan G Kruger ,Rita Shaknovich ,Ann M Haberman ,Giorgio Inghirami ,Scott W Lowe ,Ari M Melnick

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma

Lsd1 作为 Gfi1 激活型髓母细胞瘤的治疗靶点

Catherine Lee, Vasilisa A Rudneva, Serap Erkek, Marc Zapatka, Lianne Q Chau, Silvia K Tacheva-Grigorova, Alexandra Garancher, Jessica M Rusert, Ozlem Aksoy, Robin Lea, Helai P Mohammad, Jianxun Wang, William A Weiss, H Leighton Grimes, Stefan M Pfister, Paul A Northcott, Robert J Wechsler-Reya

Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

靶向增强子转换可克服急性髓系白血病中的非遗传性耐药性

Charles C Bell ,Katie A Fennell ,Yih-Chih Chan ,Florian Rambow ,Miriam M Yeung ,Dane Vassiliadis ,Luis Lara ,Paul Yeh ,Luciano G Martelotto ,Aljosja Rogiers ,Brandon E Kremer ,Olena Barbash ,Helai P Mohammad ,Timothy M Johanson ,Marian L Burr ,Arindam Dhar ,Natalie Karpinich ,Luyi Tian ,Dean S Tyler ,Laura MacPherson ,Junwei Shi ,Nathan Pinnawala ,Chun Yew Fong ,Anthony T Papenfuss ,Sean M Grimmond ,Sarah-Jane Dawson ,Rhys S Allan ,Ryan G Kruger ,Christopher R Vakoc ,David L Goode ,Shalin H Naik ,Omer Gilan ,Enid Y N Lam ,Jean-Christophe Marine ,Rab K Prinjha ,Mark A Dawson

LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML

LSD1抑制剂通过重新激活急性髓系白血病(AML)中的PU.1和C/EBPα依赖性增强子发挥其抗白血病作用。

Cusan, Monica; Cai, Sheng F; Mohammad, Helai P; Krivtsov, Andrei; Chramiec, Alan; Loizou, Evangelia; Witkin, Matthew D; Smitheman, Kimberly N; Tenen, Daniel G; Ye, Min; Will, Britta; Steidl, Ulrich; Kruger, Ryan G; Levine, Ross L; Rienhoff, Hugh Y Jr; Koche, Richard P; Armstrong, Scott A

Antitumor activity of LSD1 inhibitors in lung cancer

LSD1抑制剂在肺癌中的抗肿瘤活性

Mohammad, Helai P; Kruger, Ryan G