日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The long noncoding RNA VIM-AS1 and nucleoporin Nup358/RanBP2 regulate SMAD nuclear accumulation during TGF-β signaling.

长链非编码RNA VIM-AS1和核孔蛋白Nup358/RanBP2在TGF-β信号传导过程中调节SMAD核积累。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf1526
Rodrigues-Junior Dorival Mendes, Ali Mohamad Moustafa, Itoh Yuka, Ferreira Mafalda Sousa, Heldin Johan, Fu Hao, Hoelz André, Heldin Carl-Henrik, Moustakas Aristidis
信号转导
RAN
发表日期：2026
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TGFβ signaling promotes cell cycle progression and resistance to the CDK4/6 inhibitor palbociclib through SOX4 transcriptional modulation in breast cancer cells

TGFβ信号通路通过SOX4转录调控促进乳腺癌细胞的细胞周期进程和对CDK4/6抑制剂帕博西尼的耐药性

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-026-08435-4
Ali, Mohamad Moustafa; Itoh, Yuka; Badji, Aisha Mariama Pereira; Gallant, Sarah; Tsirigoti, Chrysoula; Bai, Yu; Filipek-Górniok, Beata; Miyazawa, Keiji; Heldin, Carl-Henrik; Moustakas, Aristidis
CDK4
肿瘤
SOX
表观遗传
肿瘤免疫
信号转导
SOX4
乳腺癌
细胞生物学
TGFβ
转录调控
发表日期：2026
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Opposing effects of Rho-associated coiled-coil kinase 1 (ROCK1) and ROCK2 in TGF-β-SMAD signaling.

Rho相关卷曲螺旋激酶1（ROCK1）和ROCK2在TGF-β-SMAD信号传导中的相反作用。

期刊:Cell Communication and Signaling
影响因子:8.9
doi:10.1186/s12964-026-02722-5
Bai Yu, Ali Mohamad Moustafa, van Dinther Maarten, Ten Dijke Peter, Moustakas Aristidis, Sundqvist Anders, Heldin Carl-Henrik
ROCK2
信号转导
ROCK
ROCK1
发表日期：2026
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Correction: LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation

更正：LXRα限制TGFβ依赖性肝细胞癌相关成纤维细胞分化

期刊:Oncogenesis
影响因子:6.4
doi:10.1038/s41389-026-00610-8
Morén, Anita; Bellomo, Claudia; Tsubakihara, Yutaro; Kardassis, Dimitris; Mikulits, Wolfgang; Heldin, Carl-Henrik; Moustakas, Aristidis
成纤维细胞
肿瘤
肿瘤免疫
细胞生物学
TGFβ
发表日期：2026
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Increased affinity by dimerization of radiolabeled Affibody molecule ATH001 targeting PDGFRβ

放射性标记的Affibody分子ATH001通过二聚化作用增强其对PDGFRβ的亲和力

期刊:EJNMMI Radiopharmacy and Chemistry
影响因子:3.3
doi:10.1186/s41181-026-00439-x
Abouzayed, Ayman; Olsson, Hugo; Papadopoulos, Natalia; Mitran, Bogdan; Mallapura, Hemantha; Akter, Tahmida; Velikyan, Irina; Korsgren, Olle; Heldin, Carl-Henrik; Löfblom, John; Wagner, Michael; Eriksson, Olof
发表日期：2026
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Precise mapping of single-stranded DNA breaks by sequence-templated erroneous DNA polymerase end-labelling.

利用序列模板错误DNA聚合酶末端标记法精确定位单链DNA断裂

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-62512-4
Wenson Leonie, Heldin Johan, Martin Marcel, Erbilgin Yücel, Salman Barış, Sundqvist Anders, Schaal Wesley, Sandbaumhüter Friederike A, Jansson Erik T, Chen Xingqi, Davidsson Anton, Stenerlöw Bo, Espinoza Jaime A, Lindström Mikael, Lennartsson Johan, Spjuth Ola, Söderberg Ola
其它
发表日期：2025
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The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma

转录因子LHX2介导并增强髓母细胞瘤中的致癌性BMP信号传导

期刊:Cell Death and Differentiation
影响因子:15.4
doi:10.1038/s41418-025-01488-6
Ohata, Yae; Ali, Mohamad M; Tsubakihara, Yutaro; Itoh, Yuka; Rosén, Gabriela; Bergström, Tobias; Morén, Anita; Golán-Cancela, Irene; Nakada, Ayana; Voytyuk, Oleksandr; Tsuchiya, Maiko; Fukui, Rei; Yamamoto, Kouhei; Martín-Rubio, Paula; Sancho, Patricia; Strell, Carina; Micke, Patrick; Wechsler-Reya, Robert J; Hashizume, Yoshinobu; Miyazono, Kohei; Caja, Laia; Heldin, Carl-Henrik; Swartling, Fredrik J; Moustakas, Aristidis
信号转导
细胞生物学
肿瘤
肿瘤免疫
发表日期：2025
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TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles

TGF-β诱导胆固醇蓄积调控肿瘤来源的细胞外囊泡分泌

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:11.4
doi:10.1186/s13046-025-03291-0
Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Konstantina Psatha, Dimitris Kletsas, Michalis Aivaliotis, Carl-Henrik Heldin, Aristidis Moustakas
肿瘤
肿瘤细胞
TGF-β
MEK1
发表日期：2025
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Mice carrying nonsense mutant p53 develop frequent multicentric or metastatic tumors.

携带无义突变 p53 的小鼠经常发生多中心或转移性肿瘤。

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-08290-9
Strandgren Charlotte, Rondahl Veronica, Oppelt Ann-Sophie, Öhlin Susanne, Heldin Angelos, Wiman Klas G
心血管
P53
发表日期：2025
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PDGFRß targeted positron emission tomography as a non-invasive biomarker for activated hepatic stellate cells: lasts steps before clinical translation.

PDGFRß靶向正电子发射断层扫描作为活化肝星状细胞的非侵入性生物标志物：临床转化前的最后步骤。

期刊:EJNMMI Radiopharmacy and Chemistry
影响因子:3.3
doi:10.1186/s41181-025-00410-2
Yashaswini Chittampalli N, Mitran Bogdan, Papadopoulos Natalia, Wegrzyniak Olivia, Löfblom John, Nordström Helena, Velikyan Irina, Abouzayed Ayman, Johansson Lars, Hagmar Per, Wagner Michael, Frejd Fredrik Y, Korsgren Olle, Heldin Carl-Henrik, Friedman Scott L, Eriksson Olof
细胞生物学
发表日期：2025
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